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이진헌,강진경,박인서,송건훈,정재복,백용한,송시영,서정훈 대한소화기학회 1998 대한소화기학회지 Vol.32 No.3
Background/Aims: Inflammatory diseasas of the pancreas are not uncommon. The advanced age is one of the significant factors in assessing the severity of acute pancreatitis. It has been shown that the biliary tract disease is a more frequent cause of acute pancreatitis in the elderly than in the young. With the increased life span, the elderly are comprising a large proportion of the population. As a result, physicians are more often being faced with acute pancreatitis in the elderly. The purpose af this study was to evaluate clinical features of acute panereatitis in the elderly. Methods: A total of 188 patients with acute pancreatitis were reviewed. We investigated the differences of clinical characteristics between the elderly patients aged over 60 and the young patients aged under 60. Results: The sex distribution showed male preponderance in the young patients (M:F=2.4:1), but was nearly equal in the elderly patients (M:F=1.1:1). The most common cause of acute pancreatitis in the elderly was biliary tract disease (52.5%), while alcohol abuse was the most common cause in the young patients (38.8%), Local complications of acute pancreatitis, such as psuedocyst, necrosis, abscesses were not differently shown between the elderly (16.9%) and the young (20.2%) patients. Systemic complications including acute puhnonary failure occurred more frequently in the elderly patients than the young patients. The mortality rate of the elderly patients (5.1%) was not significantly different from that of the young patients (3.1%). Conclusions: To detect correctable underlying bihary tract diseases the elderly patients with acute pancreatitis should be completely investigated using endoscopic retrograde cholangiopancreatography (ERCP). In addition, the patient should be closely monitored for the development of the systemic complications during the disease process.
이진복,강성재,김영호 한국전문물리치료학회 2002 한국전문물리치료학회지 Vol.9 No.3
In this study, vertical acceleration of center of mass was observed along normal gait phases in 9 healthy male volunteers (aged 25.7±2.18). The developed wireless accelerometric device was attached on the intervertebral space between L3 and L4 using a semi-elastic waist belt. A three-dimensional motion analysis system, synchronized with the accelerometry, was used for detecting gait phases. There was no significant correlation between the body weight and the acceleration. The first peak curve covered loading response phase. The second downward peak point was matched accurately with the opposite toe-off. In mid-stance and terminal stance, the acceleration curve highly resembled the vertical ground reaction force curve. There was no significant difference in timing between the final upward peak point and the initial contact. Therefore, the developed accelerometry system would be helpful in determining determine temporal gait patterns in patients with gait disorders.
위장관 ( 胃腸管 ) : 약년자 대장 및 직장암의 임상적 고찰
강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),정재복(Jae Bock Chung),김원호(Won Ho Kim),김경희(Kyung Hee Kim),노성훈(Sung Hoon Noh),김도영(Doe Young Kim) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.1
N/A Colorectal carcinoma in young patients reportedly has a poor prognosis. Several reviews have suggested multiple explantations, including a low index of suspicion, delay in diagnosis or uniquely virulent tumor cells. However, some recent articles have suggested that the outlook is not necessarily dismal. To identify any distinctive characteristics of colorectal cancer in young patients, we studied the difference of incidence, initial symptoms, duration of symptoms, the location, gross types and size of the tumor, depth of invasion, resectability, lymph node involvement, distant metastasis, tumor stage by Astler-Coller classification, histologic types and five-year survival rates between 91 cases of young patients (less than 35 years of age) with colorectal cancer and 915 cases of eldly patients (35 years of age or more) as control, who were operated at Yonsei University Medical College, Severance Hospital during the 18 year period between January 1971 and December 1988. The results obtained are as follows: 1) The incidence of colorectal carcinoma in the young among total colorectal cancer patients was 9.0% (91/1,006 cases). There were 44 males and 47 females in the young age group, and the male to female ratrio was 0.93 : l. 2) There were no differences in the clinical symptoms, location, size, gross types of tumor and resectability between the two groups. 3) The duration of symptoms was longer in the younger age group than in the older age group. 4) The incidence of lymph node involvement was significantly higher in the younger age group than in the older age group (62.8% vs 39.2%; p<0.001). 5) The incidence of modified Dukes C cases was significantly higher in the younger age group than in the older age group (49.5% vs 33.49% p<0.001). 6) The incidence of mucinous carcinoma was significantly higher in the younger age group than in the older age group (32.5% vs. 10.1%; p<0.001). 7) The cumulative five-year survival rate was significantly lower in the younger age group than in the older age group (34.1% vs. 58.0%; p<0.005). 8) Even in the same stage or in the same status of lymph node involvement or with the same histologic type, the five-year survival rate was significantly lower in the younger age group than in the older age group. We conclude that the colorectal caricr in younger patients is worse than older patients. This unfavorable prognosis in young patients with colorectal cancer may be related to delayed diagnosis, more malignant histologic feature and other unidentified causes such as host factor. We suggest that a high degee of index of suspicion and aggressive treatment is mandatory even in young patients.
윤영진 ( Young Jin Yun ),이진무 ( Jin Moo Lee ),이창훈 ( Chang Hoon Lee ),장준복 ( Jun Bock Jang ),이경섭 ( Kyung Sub Lee ) 대한한방부인과학회 2012 大韓韓方婦人科學會誌 Vol.25 No.2
Objectives: This study was conducted to evaluate the inhibitory effect of Melia Fructus extract on osteoclast differentiation. Methods: MTT-assay was performed to estimate cytotoxicity of Melia Fructus extract in BMMs stimulated with M-CSF. TRAP staining, TRAP activity and Real-time PCR were performed to know the inhibitory effect on osteoclast differentiation. Actin ring formation were analysed to observe the effect of Melia Fructus extract. Results: Melia Fructus extract decreased the number of TRAP positive cells and the expression of NFATc1 gene, c-Fos gene, TRAP and OSCAR in BMMs stimulated with RANKL. Melia Fructus extract has no cytotoxicity at the concentration used in this study. Melia Fructus extract restrained the formation of actin ring. Melia Fructus inhibited NF-κB activity by inducing degradation of p-IkBα. Conclusions: Melia Fructus has the inhibitory effect of osteocalst differentiation and bone resorption. Further studies are needed to treat osteoporosis by herbal medicine containing Melia Fructus.
윤영진 ( Young Jin Yun ),이진무 ( Jin Moo Lee ),이창훈 ( Chang Hoon Lee ),장준복 ( Jun Bock Jang ),이경섭 ( Kyung Sub Lee ),황덕상 ( Deok Sang Hwang ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.1
The purpose of this study is to report the effect on cold hypersensitivityof hands, feet and low abdomen by Sasang constitutional treatment. For this purpose, the effects of a treatment were measured quantitatively using Digital InfraredThermographic Imaging (DITI). Methods: It was a case of report, the patient was a 25-year-old female whosechief complaint was cold hypersensitivity of hands and feet and low abdomem. We treated the patient with Sasang constitutional treatment, and the effect of atreatment was evaluated by DITI. Results: After Sasang constitutional treatment, the differences of temperatureof hands, feet and low abdomem were decreased on DITI screening, respectively. Conclusions: Sasang constitutional treatment on cold hypersensitivity of hands, feet and low abdomen is effective. Further studies on diagnosis tools of low abdomencold hypersensitivity are needed.