http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
MicroRNA Let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis
( Bing Qin ),( Bo Xiao ),( De Sheng Liang ),( Ye Li ),( Ting Jiang ),( Huan Yang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.8
Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. MiRNA let-7 family is known to be involved in the regulation of cell apoptosis. However, the function of let-7 in ox-LDL induced ECs apoptosis and atherosclerosis is still unknown. Here, we show that let-7c expression was markedly up-regulated in ox-LDL induced apoptotic human umbilical cord vein endothelial cells (HUVECs). Let-7c over-expression enhanced apoptosis in ECs whereas inhibition of let-7c could partly alleviate apoptotic cell death mediated by ox-LDL. Searching for how let-7c affected apoptosis, we discovered that antiapoptotic protein Bcl-xl was a direct target of let-7c in ECs. Our data suggest that let-7c contributes to endothelial apoptosis through suppression of Bcl-xl. [BMB Reports 2012; 45(8): 464-469]
Qin, Yi,Chen, Jing,Li, Li,Liao, Chun-Jie,Liang, Yu-Bing,Guan, En-Jian,Xie, Yu-Bo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Morphine is not only an analgesic treating pain for patients with cancer but also a potential anticancer drug inhibiting tumor growth and proliferation. To gain better insight into the involvement of morphine in the biological characteristics of gastric cancer, we investigated effects on progression of gastric carcinoma cells and the expression of some apoptosis-related genes including caspase-9, caspase-3, survivin and NF-${\kappa}B$ using the MGC-803 human gastric cancer cell line. The viability of cells was assessed by MTT assay, proliferation by colony formation assay, cell cycle progression and apoptosis by flow cytometry and ultrastructural alteration by transmission electron microscopy. The influences of morphine on caspase-9, caspase-3, survivin and NF-${\kappa}B$ were evaluated by semi-quantitative RT-PCR and Western blot. Our data showed that morphine could significantly inhibit cell growth and proliferation and cause cell cycle arrest in the G2/M phase. MGC-803 cells which were incubated with morphine also had a higher apoptotic rate than control cells. Morphine also led to morphological changes of gastric cancer cells. The mechanism of morphine inhibiting gastric cancer progression in vitro might be associated with activation of caspase-9 and caspase-3 and inhibition of survivin and NF-${\kappa}B$.
Streptomyces lushanensis sp. nov., a novel actinomycete with anti-cyanobacterial activity
Zhang, Bing-Huo,Cheng, Juan,Chen, Wei,Li, Han-Quan,Yang, Jian-Yuan,Park, Dong-Jin,Kim, Chang-Jin,Shen, Rui,Duan, Yan-Qin,Li, Wen-Jun Nature Publishing Group 2015 The Journal of Antibiotics Vol. No.
<P>Strain JXJ 0135(T), an anti-cyanobacterial actinomycete, was isolated from a soil sample collected from Lushan Mountain, south China, and identified by using polyphasic approach. Phylogenetic analysis of the near-complete 16S rRNA gene sequence indicated that strain JXJ 0135(T) belongs to the genus Streptomyces and exhibited distinct subclade and also highest similarity (98.6%) to Streptomyces scopuliridis RB72(T). The strain developed well-branched substrate and aerial mycelia, and produced spiral spore chains. Spores were elliptical and the spore surface was smooth. The strain contained LL-diaminopimelic acid with whole-cell sugars of mannose, rhamnose, glucose and galactose. Phospholipids were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol mannosides, phosphotidylinositol dimannoside, an unidentified aminophospholipid and an unknown phospholipid. The menaquinones were MK-9(H6) and MK-9(H8). The major components of the fatty acids were anteiso-C15:0, iso-C16:0, anteiso-C17:0, iso-C15:0, C16:0, iso-C17:0 and iso-C14:0. The G+C content was 69.3?mol%. The DNA-DNA hybridization value between JXJ 0135(T) and S. scopuliridis RB72(T) was 41.21.4%. On the basis of the polyphasic data, strain JXJ 0135(T) represents a novel species of the genus Streptomyces, for which the name Streptomyces lushanensis sp. nov. is proposed. The type strain is JXJ 0135(T) (=DSM 42121(T)=JCM 19628(T)=KCTC 29261(T)=KACC 17834(T)=NRRL B-24994(T)).</P>
Kaili Qin,Jingling Li,Yanqing Zhu,Xueqing Xu,Xiudi Xiao,Bing Deng,Juan Yang,Zhuoneng Bi,Shuaijun Chen,Gang Xu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.8
Crystal structure control is so important to the fluorescence properties that each element should be considered carefully. In conventional synthesis of ZnxCd1-xS alloyed nanocrystals (NCs), most of studies focus on ligand–surface interaction on the formation of either zinc blende or wurtzite ZnxCd1-xS nanocrystals, instead of the reactant source. In this work, mixed crystal phase was found easily in ZnxCd1-xS alloyed NCs when reaction proceeded at high Zn/Cd source ratio condition. Therefore, we regulate the Zn/Cd ratio to obtain relative pure zinc-blende structure, and study the influence of structure change on the fluorescence properties. Further, we have proposed a two-step ZnS coating method to acquire ZnxCd1-xS/ZnS NCs with separated crystal-phase between core and shell. Compared with maximum QY of 81% for ZnxCd1-xS/ZnS NCs synthesized by conventional one-step coating method, the performance of the optimized NCs has significantly improved with maximum QY of 93%.
The Topic Detection and Tracking with Topic Sensitive Language Model
Ruifang He,Bing Qin,Ting Liu,Sheng Li 한국어정보학회 2006 한국어정보학 Vol.8 No.1
In this paper, we explore the language model with topic sensitive features for the topic detection and tracking, formulate the relationship among the Chinese internet new words, language model with topic sensitive feature and the scheduling logic and the interval temporal reasoning and the key techniques. we use the Chinese internet new words to strengthen the detection and tracking of the topic and try to employ the scheduling logic and interval temporal reasoning to educe the reciprocal influences of events. At last we summarize the potential issues and the future work.
Semi-analytical solution of horizontally composite curved I-beam with partial slip
Xu-xi Qin,Han-bing Liu,Chunli Wu,Zheng-wei Gu 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.27 No.1
This paper presents a semi-analytical solution of simply supported horizontally composite curved I-beam by trigonometric series. The flexibility of the interlayer connectors between layers both in the tangential direction and in the radial direction is taken into account in the proposed formulation. The governing differential equations and the boundary conditions are established by applying the variational approach, which are solved by applying the Fourier series expansion method. The accuracy and efficiency of the proposed formulation are validated by comparing its results with both experimental results reported in the literature and FEM results.