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Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats
Soung Baek Jang,Dongju Kim,Seong Yeon Kim,Changhee Park,Ji Hoon Jeong,Hyo-Jeong Kuh,Jaehwi Lee 대한생리학회-대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.1
The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.
프리피스톤 수소기관의 고효율 및 NOx 저감 가능성에 관한 연구
백대하(Daeha Baek),변창희(Changhee Byun),이종태(Jongtai Lee) 한국자동차공학회 2011 한국자동차공학회 부문종합 학술대회 Vol.2011 No.5
In order to grasp the feasibility of high efficiency and low NOx emissions for H2 engine with free-piston, characteristics were analyzed by using ultra lean mixture in case of changing scavenging valve opening timing and scavenging pressure. As the results, it was shown that using ultra lean mixture is the feasibility of increasing efficiency and zero-level of NOx emissions without backfire. The other side, it was confirmed that efficiency and NOx remarkably depend on scavenging valve opening timing.
Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats
Jang, Soung Baek,Kim, Dongju,Kim, Seong Yeon,Park, Changhee,Jeong, Ji Hoon,Kuh, Hyo-Jeong,Lee, Jaehwi The Korean Society of Pharmacology 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.1
The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.
Kim, Y S,Baek, Sujin,Lee, Wonjoo,Lee, Y,Han, Sung-Hwan,Lee, Changhee,Lee, Youn-Sik,Lee, Soo-Hyoung American Scientific Publishers 2009 Journal of Nanoscience and Nanotechnology Vol.9 No.12
<P>To improve the performance of organic solar cells, various methods have been used to increase the light absorbance and electron transfer efficiency or decrease the internal resistance of the device. In this article, red dyes of phosphorescent materials are used to improve the performance of bulk heterojunction organic solar cells based on MDMO-PPV and PCBM. Solar cell devices doped with different red dyes showed higher performances in terms of current, voltage and conversion efficiency than those without red dyes. The efficiency was maximized in the devices with a 10% concentration of red dye 2, which was attributed to the longer exciton lifetimes that were induced by the triplet spin state of the red dyes allowing them to reach the p-n junction and thereby generate more photocurrent.</P>