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Polyelectrolyte Complex-Mediated Exogenous Growth Factor Delivery For Skin Scar Reduction
김교범 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
This study presents an exogenous GF delivery platform developed using coacervates (Coa), a tertiary complex of poly(ethylene argininyl aspartate diglyceride) polycation, heparin, and cargo GFs (TGF-β3 and IL-10). Coa encompasses the advantage of high biocompatibility, facile preparation, protection of cargo GFs, and sustained GF release. Coacervate-mediated dual delivery of TGF-β3/IL-10 would exhibit synergistic effects for the reduction of scar formation during physiological wound healing including enhanced skin cell activities, down-regulation of scar-related gene expression at later stages, accelerated wound closure after 3 weeks in a rat skin flap model, and enhanced formation of the epidermal layer along with facilitated angiogenesis. Therefore, we conclude that exogenous dual GF delivery via the Coa platform effectively augments both the quantity and quality of regenerated skin tissues without scar formation.
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Overview of current standpoints in profiling of circulating tumor cells
김교범,이관희,이종민,최종훈 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1
The goal of this review is summarizing currenttechnologies developed as the in vitro prognostic/diagnosticsystems that can rapidly separate and detect circulatingtumor cells (CTCs) from cancer patient’s blood(1–10 CTCs of 1 billion red blood cells) by labeled andnon-labeled method. The review is focused on three majorareas of CTC research (1) Summary of previous researchon capturing of CTCs, (2) New development of the in vitroprognostic diagnosis system of cancer that is capable ofrapid separation of CTCs, (3) Future direction on developmentof new technologies for CTC profiling. CurrentCTC researches have helped on identifying patients whomay benefit from chemotherapy before treatment, patientswho may benefit from continued chemotherapy, and leadingto clinical development of CTC-guided chemotherapystrategies. We analyze the feasibility of clinical applicationof these current CTC research for the ultimate goal ofincreasing the survivability of cancer patient. The biomolecularassays of viable CTCs from cancer patient may elucidate the mechanism of metastasis and tumor initiatingcells and also may have high impact on the development ofpersonalized medicine to overcome the incurable diseases.
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