Pectus Excavatum and Pectus Carinatum: Associated Conditions, Family History, and Postoperative Patient Satisfaction

Pinar Kuru, M.D.,Aylin Cakiroglu, M.I.,Aynur Er, M.S.,Hincal Ozbakir, M.I.,Ali Emin Cinel, M.S.,Busra Cangut, M.S.,Merve Iris, M.S.,Berkay Canbaz, M.S.,Ebru Pıçak, M.S.,Mustafa Yuksel, M.D. 대한흉부외과학회 2016 Journal of Chest Surgery (J Chest Surg) Vol.49 No.1

Background: Pectus excavatum (PE) and pectus carinatum (PC) are the most common chest wall deformities. In this study, we aimed to characterize how patients obtained information about these deformities, as well as patients’ family history, associated medical problems, and postoperative satisfaction after the Nuss and Abramson procedures. Methods: This cross-sectional retrospective study included patients who were operated by a single surgeon between 2006 and 2013. Follow-up calls were made after approval of our institution’s ethics committee. We reached 207 of the 336 PE patients (61.6%) and 73 of the 96 PC patients (76%). Results: The majority of the patients were male (85% of the PE patients and 91.8% of the PC patients). The age of diagnosis of PE was 14.52±0.51 years and the age at the time of operation was 17.89±0.42 years; for PC patients, the corresponding ages were 15.23±0.55 years and 16.77±0.55 years, respectively. A total of 70% of the PE patients and 63.8% of the PC patients obtained information about pectus deformities through the Internet. In 27.1% of the PE patients with an associated anomaly, 57.1% (n=13) had scoliosis, while 41.1% of the PC patients with an associated anomaly had kyphosis (n=5). Postoperative satisfaction, as evaluated on a scale from 0 to 10, was 8.17±0.15 for PE patients and 8.37±0.26 for PC patients. The postoperative pain duration was 51.93±5.18 days for PE patients and 38.5±6.88 days for PC patients. Conclusion: In this study, we found that most patients with pectus deformities were male. The Internet was an important resource for patients to learn about their deformities. Family history and associated anomalies were identified as important aspects for consideration in the clinical setting. The patients reported high levels of postoperative satisfaction, and pain management was found to be one of the most important elements of postoperative care.

Numerical study of the cyclic behavior of steel plate shear wall systems (SPSWs) with differently shaped openings

Mustafa M. Ali,S.A. Osman,O.A. Husam,Ahmed W. Al-Zand 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.26 No.3

This paper presents the development of finite element (FE) models to simulate the behavior of diagonally stiffened steel plate shear wall systems (SPSWs) with differently shaped openings subjected to a cyclic load. This walling system has the potential to be used for shear elements that resist lateral loads in steel-framed buildings. A number of ½-scale one-story buildings that were un-stiffened, stiffened and stiffened with opening SPSWs are modeled and simulated using the finite element method based on experimental data from previous research. After validating the finite element (FE) models, the effects of infill plate thickness on the cyclic behavior of steel shear walls are investigated. Furthermore, triple diagonal stiffeners are added to the steel infill plates of the SPSWs, and the effects are studied. Moreover, the effects of a number of differently shaped openings applied to the infill plate are studied. The results indicate that the bearing capacity and shear resistance are affected positively by increasing the infill plate thickness and by adding triple diagonal stiffeners. In addition, the cyclic behavior of SPSWs is improved, even with an opening in the SPSWs.

Hysteretic characteristics of steel plate shear walls: Effects of openings

Mustafa M. Ali,S.A. Osman,M.Y.M. Yatim,Al Zand A.W. 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.76 No.6

Openings in steel plate shear walls (SPSWs) are usually used for decorative designs, crossing locations of multiple utilities and/or structural objectives. However, earlier studies showed that generating an opening in an SPSW has a negative effect on the cyclic performance of the SPSW. Therefore, this study proposes tripling or doubling the steel-sheet-plate (SSP) layer and stiffening the opening of the SPSW to provide a solution to undesirable opening effects, improve the SPSW performance and provide the infill option of potential strengthening measures after the construction stage. The study aims to investigate the impact of SSP doubling with a stiffened opening on the cyclic behaviour, expand the essential data required by structural designers and quantify the SPSW performance factors. Validated numerical models were adopted to identify the influence of the chosen parameters on the cyclic capacity, energy dissipation, ductility, seismic performance factors (SPF) and stiffness of the suggested method. A finite Element (FE) analysis was performed via Abaqus/CAE software on half-scale single-story models of SPSWs exposed to cyclic loading. The key parameters included the number of SSP layers, the opening size ratios corresponding to the net width of the SSP, and the opening shape. The findings showed that the proposed assembly method found a negligible influence in the shear capacity with opening sizes of 10, 15, 20%. However, a deterioration in the wall strength was observed for openings with sizes of 25% and 30%. The circular opening is preferable compared with the square opening. Moreover, for all the models, the average value of the obtained ductility did not show substantial changes and the ultimate shear resistance was achieved after reaching a drift ratio of 4.36%. Additionally, the equivalent sectional area of the SSP in the twin and triple configuration of the SPSWs demonstrated approximately similar results. Compared with the single SSP layer, the proposed configuration of the twin SSP layer with a stiffened opening suggest to more sufficiency create SSP openings in the SPSW compared to that of other configurations. Finally, a tabular SPF quantification is exhibited for SPSWs with openings.

Corrosion Protection Effectiveness and Adsorption Performance of Schiff Base-Quinazoline on Mild Steel in HCl Environment

Ahmed A. Alamiery,Firas F. Sayyid,Ali M. Mustafa,Mahdi M. Hanoon,Lina M. Shaker 한국부식방식학회 2022 Corrosion Science and Technology Vol.21 No.2

Schiff base quinazoline derivative viz., 3-((2-hydroxy-3-methoxybenzylidene)amino)-2-methylquinazolin-4(3H)-one (SB-Q), was synthesized in this study. Its corrosion protection impact on mild steel (MS) in 1 Mhydrochloric acid solution was examined by performing weight loss measurements. The protective efficacyof SB-Q on MS in 1 M HCl was investigated based on its concentrations, immersion period, and immersion temperature. SB-Q was found to be an efficient inhibitor for the corrosion of MS. Its inhibitionefficiency was improved by increasing the concentration of SB-Q to an optimal concentration of 500 ppm. Its inhibition efficacy was 96.3% at 303K. Experimental findings revealed that its inhibition efficiency was increased with increasing immersion time, but decreased with an increase in temperature. The adsorption of SB-Q molecules was followed the Langmuir adsorption isotherm model. The adsorption of the examined inhibitor molecules on the surface of mild steel was studied by density functional theory (DFT). DFT investigation confirmed weight loss findings.

Gravimetric Measurements and Theoretical Calculations of 4-Aminoantipyrine Derivatives as Corrosion Inhibitors for Mild Steel in Hydrochloric Acid Solution: Comparative Studies

A. A. Al-Amiery,Firas F. Sayyid,Ali M. Mustafa,Slafa I. Ibrahim,Mustafa K. Mohsin,Mahdi M. Hanoon,Mohammed H. H. Al-Kaabi,A. A. H. Kadhum,Wan Nor Roslam Wan Isahak 한국부식방식학회 2023 Corrosion Science and Technology Vol.22 No.2

Due to continuous promotion of green alternatives to toxic petrochemicals by government policies,research efforts towards the development of green corrosion inhibitors have intensified recently. The objectiveof the current work was to develop novel green and sustainable corrosion inhibitors derived from 4-aminoantipyrine to effectively prevent corrosion of mild steel in corrosive environments. Gravimetricmethods were used to investigate corrosion inhibition of 4-((furan-2-ylmethylene)amino)antipyrine (FAP)and 4-((pyridin-2-ylmethylene)amino)antipyrine (PAP) for mild steel in 1 M HCl. FAP and PAP were subjectedto quantum chemical calculations using density functional theory (DFT). DFT was used to determinethe mechanism of mild steel corrosion inhibition using inhibitors tested in HCl. Results demonstratedthat these tested inhibitors could effectively inhibit mild steel corrosion in 1.0 M HCl. At 0.0005 M, theseinhibitors’ efficiencies for FAP and PAP were 93.3% and 96.5%, respectively. The Langmuir adsorptionisotherm was obeyed by these inhibitors on the mild steel surface. Values of adsorption free energies,, revealed that FAP followed chemical and physical adsorptions.

2-deoxy-D-Glucose Synergizes with Doxorubicin or L-Buthionine Sulfoximine to Reduce Adhesion and Migration of Breast Cancer Cells

Mustafa, Ebtihal H,Mahmoud, Huda T,Al-Hudhud, Mariam Y,Abdalla, Maher Y,Ahmad, Iman M,Yasin, Salem R,Elkarmi, Ali Z,Tahtamouni, Lubna H Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

Background: Cancer metastasis depends on cell motility which is driven by cycles of actin polymerization and depolymerization. Reactive oxygen species (ROS) and metabolic oxidative stress have long been associated with cancer. ROS play a vital role in regulating actin dynamics that are sensitive to oxidative modification. The current work aimed at studying the effects of sub-lethal metabolic oxidative stress on actin cytoskeleton, focal adhesion and cell migration. Materials and Methods: T47D human breast cancer cells were treated with 2-deoxy-D-glucose (2DG), L-buthionine sulfoximine (BSO), or doxorubicin (DOX), individually or in combination, and changes in intracellular total glutathione and malondialdehyde (MDA) levels were measured. The expression of three major antioxidant enzymes was studied by immunoblotting, and cells were stained with fluorescent-phalloidin to evaluate changes in F-actin organization. In addition, cell adhesion and degradation ability were measured. Cell migration was studied using wound healing and transwell migration assays. Results: Our results show that treating T47D human breast cancer cells with drug combinations (2DG/BSO, 2DG/DOX, or BSO/DOX) decreased intracellular total glutathione and increased oxidized glutathione, lipid peroxidation, and cytotoxicity. In addition, the drug combinations caused a reduction in cell area and mitotic index, prophase arrest and a decreased ability to form invadopodia. The formation of F-actin aggregates was increased in treated T47D cells. Moreover, combination therapy reduced cell adhesion and the rate of cell migration. Conclusions: Our results suggest that exposure of T47D breast cancer cells to combination therapy reduces cell migration via effects on metabolic oxidative stress.

An Experimental Investigation on Flexural Behavior of RC Beams Strengthened with Different Techniques

M. Mustafa Önal,Bas¸ak Zengin,Ali Koçak,Bilge Doran 대한토목학회 2014 KSCE JOURNAL OF CIVIL ENGINEERING Vol.18 No.7

In in many earthquake-prone regions and countries including Mediterranean area, India, the Middle East, Southeast Asia, existing buildings with its structural elements such as Reinforced Concrete (RC) beams and columns, which show little ductility, have consistently exhibited poor performance during past earthquakes and consequently unavoidable earthquake damages on these structures led to a significant loss of world cultural heritage. Therefore, appropriate strengthening techniques have to be implemented in order to improve load carrying capacities and overall ductility. This paper summarizes experimental investigations of damaged and undamaged RC beams. In this context, twenty-seven beams were tested under combined bending and shear. Eighteen RC beams were damaged and then strengthened with four different methods while nine were kept undamaged. The behavior of damaged and undamaged RC beams is discussed with emphasis on the load deflection and strain characteristics. The results indicate that the specimens strengthened with full jacketing had slightly higher load carrying capacity than the reference beams strengthened with other techniques. The experimental results can also be used for understanding the most convenient strengthened technique for damaged beams.

A first-principles study of B3O3 monolayer as potential anode materials for calcium-ion batteries

Kadhim Mustafa M.,Majdi Ali,Hachim Safa K.,Abdullaha Sallalh. Ahmed,Taban Taleeb Zedan,Rheima Ahmed Mahdi 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.7

Anodic materials with fast kinetics and high capacity are prerequisites for improvement of calcium-ion batteries (CIBs). According to first-principles computations, unique calcium capacity was discovered for B3O3 monolayer. Based on findings, Ca atoms can be adsorbed on B3O3 surface, and the most stable location is the top of the pore center of B3O3 monolayer. Binding energy of B3O3 monolayer is relatively high for Ca atoms. In addition, Ca atoms have been shown to more simple diffuse on B3O3 surface, and lowest diffusion barrier was 65 meV. A more significant finding is that B3O3 monolayer-based nanostructures possess a relatively large capacity of 616.05 mAh/g (as Ca.51BO). These results are expected to support illumination mechanism of Ca storage in boron oxide materials with low-dimensional structures and pave the way for design of CIBs. Therefore, we can utilize the B3O3 anode-based CIBs as alternatives to normal Ca-ion batteries.

Weekly Topotecan for Recurrent Small Cell Lung Cancer - a Retrospective Anatolian Medical Oncology Group Study

Altinbas, Mustafa,Kalender, Mehmet Emin,Oven, Basak,Sevinc, Alper,Karaca, Halit,Kaplan, M. Ali,Alici, Suleyman,Arpaci, Erkan,Yildiz, Ramazan,Uncu, Dogan,Camci, Celalettin,Gumus, Mahmut Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Aim: To evaluate efficacy and tolerability of topotecan treatment for recurrent small cell lung carcinoma. Patients and Methods: A total of 62 patients were evaluated retrospectively. Statistical analysis was performed using GraphPad Instat (version 3.05). Results: DFifty five of patients (89%) were male and 7 (11%) were female. Median age was $56.7{\pm}9.3$ (34-75). Forty eight of patients (80%) were extensive stage (ES) at the time of diagnosis. Fifty of the patients (80.6 Medical Oncology Clinic) were given median 5.36 cycles of cisplatin-etoposide (2-8 cycles). Time to recurrence was $15.6{\pm}6.13$ weeks in patients with limited stage (LS) and $6.3{\pm}3.82$ weeks in extensive stage (ES) (p<0.0001). Overall survival was $14.0{\pm}6.08$ months in ES and $17.9{\pm}6.88$ months in LS. The difference between two groups was statistically meaningful (p=0.0447). The overall survival of the patients was $14.8{\pm}6.43$ months (4.5-40 months). In terms of survival, there was no difference between males and females (p=0.1171). In 17 (27%) patients who were refractory to topotecan or in whom progression occurred other chemotherapies were used. Conclusion: Small cell lung cancer is chemosensitive, but recurrences occur in short time. Other chemotherapy regimens are used in progression. Topotecan is one of them. Patients who were young and in whom recurrences occur late had given better response to topotecan. Because of the retrospective nature of the study, we couldn't reach the records exactly and consequently, rate and duration of response couldn't be calculated. In recurrent SCLC topotecan is one of the treatment choices. But both hematological and non hematological side effects should be taken into consideration.

Assessment of the risk factors associated with multidrug-resistant tuberculosis in Sudan: a case-control study

Adel Hussein Elduma,Mohammad Ali Mansournia,Abbas Rahimi Foroushani,Hamdan Mustafa Hamdan Ali,Asrar M A,Salam Elegail,Asma Elsony,Kourosh Holakouie-Naieni 한국역학회 2019 Epidemiology and Health Vol.41 No.-

OBJECTIVES: The emergence of multidrug-resistant tuberculosis (MDR-TB) is a major challenge for the global control of tuberculosis (TB). The aim of this study was to determine the risk factors associated with MDR-TB in Sudan. METHODS: This case-control study was conducted from May 2017 to February 2019. Patients newly diagnosed with MDR-TB were selected as cases, and controls were selected from TB patients who responded to first-line anti-TB drugs. A questionnaire was designed and used to collect data from study participants. Logistic regression was used to evaluate associations between risk factors and MDR-TB infection. The best multivariate model was selected based on the likelihood ratio test. RESULTS: A total of 430 cases and 860 controls were selected for this study. A history of previous TB treatment (adjusted odds ratio [aOR], 54.85; 95% confidence interval [CI], 30.48 to 98.69) was strongly associated with MDR-TB infection. We identified interruption of TB treatment (aOR, 7.62; 95% CI, 3.16 to 18.34), contact with MDR-TB patients (aOR, 5.40; 95% CI, 2.69 to 10.74), lower body weight (aOR, 0.89; 95% CI, 0.87 to 0.91), and water pipe smoking (aOR, 3.23; 95% CI, 1.73 to 6.04) as factors associated with MDR-TB infection. CONCLUSIONS: Previous TB treatment and interruption of TB treatment were found to be the main predictors of MDR-TB. Additionally, this study found that contact with MDR-TB patients and water pipe smoking were associated with MDR-TB infection in Sudan. More efforts are required to decrease the rate of treatment interruption, to strengthen patients’ adherence to treatment, and to reduce contact with MDR-TB patients.