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Kukreja Aastha,Kang Byunghoon,Han Seungmin,Shin Moo-Kwang,손혜영,Choi Yuna,Lim Eun-Kyung,Huh Yong-Min,Haam Seungjoo 나노기술연구협의회 2020 Nano Convergence Vol.7 No.16
Manganese oxide (MnO) nanocubes were fabricated and their surface were modified by ligand encapsulation or ligand exchange, to render them water-soluble. And then, MnO formed the hollow structure by etching using acidic solution (phthalate buffer, pH 4.0). Depending on the ligand of the MnO surface, it increases the interaction between MnO and water molecules. Also, the hollow structure of MnO, as well as the ligand, can greatly enhance the acces‑ sibility of water molecules to metal ions by surface area-to-volume ratio. These factors provide high R1 relaxation, leading to strong T1 MRI signal. We have confirmed T1-weighted MR contrast effect using 4-kinds of MnO nanocubes (MnOEn, MnOEnHo, MnOEx and MnOExHo). They showed enough a MR contrast effect and biocompatibility. Espe‑ cially, among them, MnOExHo exhibited high T1 relaxivity (r1) (6.02 mM −1 s −1 ), even about 1.5 times higher sensitivity than commercial T1 MR contrast agents. In vitro/in vivo studies have shown that MnOExHo provides highly sensitive T1-weighted MR imaging, thereby improving diagnostic visibility at the disease site.
Kukreja, Aastha,Kang, Byunghoon,Kim, Hyun-Ouk,Jang, Eunji,Son, Hye Young,Huh, Yong-Min,Haam, Seungjoo Elsevier 2017 Journal of industrial and engineering chemistry Vol.48 No.-
<P><B>Abstract</B></P> <P>Multifunctional nano-systems are an enticing approach toward the design of nanoparticles with desired characteristics because of interactions between various components of the system. The combination of various imaging modalities often augments the advantages and simultaneously overcomes restrictions encountered by the individual techniques. This report describes the development of multifunctional gold core/iron oxide porous-shell nanoparticles (AuFe NPs) functionalized with matrix metalloproteinase peptide for targeted multi-mode magnetic resonance and computed tomography imaging. This study demonstrates that AuFe NPs simultaneously possess both T2-based contrast effect and X-ray attenuation properties <I>in vitro</I>. The drug loading capacity of porous iron oxide shell is also proposed.</P> <P><B>Graphical abstract</B></P> <P>Schematic representation of MT1-MMP modified, doxorubicin loaded AuFe porous core/shell nanoparticles (dAuFe/Pep). The particles simultaneously possess magnetic resonance (MR) and computed tomography (CT) contrast enhancement, along with drug loading capacity.</P> <P>[DISPLAY OMISSION]</P>
Aastha Kukreja,강병훈,김현욱,장은지,손혜영,허용민,함승주 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.48 No.-
Multifunctional nano-systems are an enticing approach toward the design of nanoparticles with desiredcharacteristics because of interactions between various components of the system. The combination ofvarious imaging modalities often augments the advantages and simultaneously overcomes restrictionsencountered by the individual techniques. This report describes the development of multifunctional goldcore/iron oxide porous-shell nanoparticles (AuFe NPs) functionalized with matrix metalloproteinasepeptide for targeted multi-mode magnetic resonance and computed tomography imaging. This studydemonstrates that AuFe NPs simultaneously possess both T2-based contrast effect and X-ray attenuationproperties in vitro. The drug loading capacity of porous iron oxide shell is also proposed.
Kukreja, Aastha,Lim, Eun-Kyung,Kang, Byunghoon,Choi, Yuna,Lee, Taeksu,Suh, Jin-Suck,Huh, Yong-Min,Haam, Seungjoo Dove Medical Press 2014 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.9 No.-
<P>In this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease.</P>
Kim, Hyun‐,Ouk,Kim, Eunjung,An, Yonghee,Choi, Jihye,Jang, Eunji,Choi, Eun Bi,Kukreja, Aastha,Kim, Myeong‐,Hoon,Kang, Byunghoon,Kim, Dong‐,Joo,Suh, Jin‐,Suck,Huh, Yong‐,Mi WILEY‐VCH Verlag 2013 Macromolecular bioscience Vol.13 No.6
<P><B>Abstract</B></P><P>Combined cancer treatment via co‐delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl‐xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy‐poly(ethylene glycol)‐<I>block</I>‐poly(<SMALL>D</SMALL>,<SMALL>L</SMALL>‐lactic acid) (mPEG‐<I>b</I>‐PLA) block copolymer polymersomes (PSomes). A study of the cytotoxicity of Bcl‐xL siRNA and DOX co‐encapsulated PSomes (CPSomes) shows more inhibited proliferation of MKN‐45 and MKN‐28 human gastric cancer cell lines than only gene‐ and drug‐loaded ones. Consequently, these results demonstrate that co‐delivery of genes and drugs using PSomes results in a synergistic efficacy and indicates the potential of PSomes as efficient nanocarriers for combined cancer therapy. </P>