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Propranolol.HCl의 Cellulose Acetate Phthalate Microencapsulation에 관한 연구
구영순,김재연,Ku, Young-Soon,Kim, Jae-Youn 대한약학회 1989 약학회지 Vol.33 No.5
Microcapsule of Propranolol HCl with Cellulose Acetate Phthalate (CAP) by coacervation-phase separation method was studied. Encapsulation was carried out in the CAP-liquid paraffin-acetone ethanol solvent system. The optimum weight ratio for microencapsulation in the CAP-liquid paraffin-solvent system was 1.32:89.18:9.50 or 1.65:89.42:8.93. The wall thickness of microcapsules increased according to increasing of CAP concentration, but dissolution rate decreased. The dissolution of propranolol-HCl in simulated gastric and intestinal fluid test solution was completed within 3 min., but T50% of propranolol HCl from 10.0% CAP-microcapsules were 390 min. and 210 min. respectively. The released amount from 12.5% CAP-microcapsules was 41.8% within 720 min. in simulatd gastric fluid test solution and T50% of those in simulated intestinal fluid test solution was 250 min.
Sodium salicylate 나일론 마이크로캅셀 제조에 미치는 Matrix의 영향
구영순,유정희,Ku, Young-Soon,Yoo, Jung-Hoo 대한약학회 1984 약학회지 Vol.28 No.4
Nylon microcapsules of sodium salicylate containing three different matrixes, acacia, gelatin and formalized gelatin, were prepared by interfacial polymerization and the effect of the matrix on the dissolution rate of sodium salicylate from its nylon microcapsule was investigated. The microcapsules were spherical and their particle diameter increased in proportion to the amount of matrix. The surface was different from each other according to the kind and the amount of matrix when observed by the scanning electron microscopy. The dissolution rate of sodium salicylate from its microcapsules was decreased by increase of the amount of matrix and the formalized gelatin most decreased the dissolution rate of drugs.
젤라틴-아리비아고무를 써서 製造한 인도메타신 마이크로캅셀의 용출 특성
구영순,김화연,Ku, Young-Soon,Kim, Hwa-Yeon 대한약학회 1984 약학회지 Vol.28 No.4
Microcapsules of indomethacin were prepared by the complex coacervation technique using gelatin-gum arabic as the wall-forming material. The effects of varying drug-to-matrix ratios and formalization time, and hydroxy propyl cellulose (HPC) added on the release of drug from microcapsules were studied. As the amount of wall-forming material increased, the drug content in the microcapsules decreased and the release of drug from microcapsules was retarded. The drug content was lower in the HPC added microcapsules than that in the microcapsules was retarded. The drug content was lower in the HPC added microcapsules than that in the microcapsules without HPC and the microcapsules with 1:4 drug-to-matrix ratio showed the slowest release. The release rate of the drug from microcapsules with 1:2 drug-to-matrix was delayed according to the increase of formalization time and the microcapsules formalized for 24hr showed ratio the most retardation.
Solvent Deposition Method를 이용(利用)한 Furosemide 제제(製劑)의 용출증대(溶出增大) Rat에서의 이용효과(利用效果)에 관한 연구(硏究)
구영순,한규정,Ku, Young-Soon,Han, Gyu-Jung 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.2
The matrix affects the dissolution of furosemide, which is almost insoluble in the dissolution medium. In order to understand the effect of the matrix on the dissolution of furosemide, lactose, starch, $Avicel\;^{\circledR}pH\;101$, $Avicel\;^{\circledR}pH\;301$, $SiO_2$ and talc were used as the matrix and the solvent deposition method were used. The dissolution characteristics of four dissolution medium were compared to each other using various ratio of drug-to-matrix. The results are as follows: 1) Lactose was shown to be superior and talc was to be inferior to the other matrixes investigated. 2) A maximum dissolution rate and dissolution amount of furosemide were observed in 1 : 10 ratio of the drug-to-matrix. 3) $T_{80%}$ of 1 : 10 ratio of the drug-to-matrix in pH 7.2 was 1 min. from FM-lactose and 30 min. from FM-talc. $T_{50%}$ in pH 4.2 is 2 min. from furosemide-lactose and 150 min. from furosemide-talc. Total amount of furosemide in pH 1.2 at 30 min. were enhanced 13.3 fold in furosemide-lactose and 3.5 fold in furosemide-talc compared to the control. Diuretic action of those furosemide-lactose and furosemide-talc was also evaluated by monitoring changes in urinary excretion of sodium, potassium and urine volume in rat. The accumulated urine volume were enhanced 1.7 fold in furosemide-lactose (1.5) compared to the furosemide.
Sodium Tripolyphosphate-Chitosan의 Polyelectrolyte Complex Coating이 Sulfanilamide 과립의 용출에 미치는 영향
구영순,김자영,김길수,Ku, Young-Soon,Kim, Ja-Young,Kim, Kil-Soo 대한약학회 1989 약학회지 Vol.33 No.6
Drug release from sulfanilamide granules coated with a polyelectrlyte complex of sodium tripolyphosphate and chitosan was studied. The coating film thickness increased with increasing concentration of chitosan in the coating solution and the drug release rates of the coated granules were significantly reduced comparing with those of the uncoated granules. $T_{50%}$ of the uncoated granules was 6 minutes, but those of the granules coated with chitosan-sodium tripolyphosphate from 0.5, 0.7, and 0.9% (w/v) chitosan-HCl solution were 27, 135, and 180 minutes, respectively in distilled water. In dissolution medium at pH 6.8, $T_{50%}$ of the uncoated granules was 4 minutes, but those of the granules coated with chitosan-sodium tripolyphosphate from 0.5, 0.7, and 0.9(w/v)% chitosan-HCl solution, were 32, 135, and 160 minutes, respectively.
Nalidixic Acid의 Eudragit RL Microencapsulation에 관한 연구
구영순(Young Soon Ku),최경주(Kyung Joo Choi) 大韓藥學會 1990 약학회지 Vol.34 No.3
Microencapsulation of nalidixic acid using Eudragit RL, a methacrylic acid copolymer was investigated. Macrocapsules were prepared by dispersing the drug solution in liquid paraffing using aluminium tristearate as dispersing agent. The preparation of the microcapsules showed high reprodulibility in particle size, shape and the drug content. The dissolution rates of Nalidixic acid from the these microcapsules considerably decreased as compared with that from Nalidixic acid powder and Nalidixic acid-Eudragit RL solid dispersions. The release of Nalidixic acid increased with increasing percentage of aluminium tristearate added to the microcapsules.
Sulfamerazine-Sugar Glass Dispersion의 용출속도에 관한 연구
구영순(Young Soon Ku),성경수(Kyung Soo Sung) 대한약학회 1990 약학회지 Vol.34 No.3
Three sugar glass dispersions of slulfamerazine were prepared using dextrose, galactose and sucrose as the carriers, with the ratio of the drug to the carrier was 1:9. The chemical stability of sulfamerazine in the glass dispersion system was studied using TLC. TLC revealed no additional spot and there was good correspondence with the Sulfamerazine itself. While time required to dissolve 50%(T50%) of sulfamerazine powder was 390 min that of dextrose glass dispersion system was 1.5 min. and galactose system was 4.0 min. in distilled water. 23) T50% of physical mixture with dextrose, galactose and sucrose were 26.4 min., 26.5 min., and 26.0 min. respectively in distilled water. T50% of control was 54 min. and those of all of the glass dispersion systems were within 1 min. in 0.1N HCl. The dissolution rates of sulfamerazine from sugar glass dispersion system in distilled water was greater than that in 0.1N HCl.
p-Aminobenzoic Acid Ester류의 약물방출에 미치는 폴리에틸렌글리콜 400의 영향
구영순(Young Soon Ku),오경희(Kyoung Hee Oh) 대한약학회 1985 약학회지 Vol.29 No.5
To clarify the diffusional behaviors of p-aminobenzoic acid esters in the presence of polyethylene glycol 400, cellulose membrane permeation rate, solubility and viscosity of p-aminobenzoic acid methyl ester, benzocaine and butamben were determined with PEG solutions of various concentrations. With an increase in PEG concentration, permeation rates from solutions decreased due to an increase in viscosity of the solution. From suspensions, however, permeation rates increased due to an increase in solubility and when the initial drug concentration was constant, permeation rates were found to be greatest from the PEG-water system with the PEG concentration which transported from the solution to the suspension. Permeation rate of 4.0mg/ml p-aminobenzoic acid methyl ester was 26.51mcg/ml.hr from 5g/100ml PEG solution, and that of 4.0mg/ml benzocaine was 13.17mcg/ml.hr from 15g/100ml PEG solution, and that of 2.0mg/ml butamben was 3.8mcg/ml.hr from 10g/100ml PEG solution. Permeation rate was 7.0 fold in p-aminobenzoic acid methyl ester and 3.5 fold in benzocaine compared to butamben.