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外科領域(一般)에 있어서 Solantal(Tiaramide)의 臨床的 ?果
李壑燮,李善亮,李燦泳 中央醫學社 1976 中央醫學 Vol.31 No.5
The main treatment of acute infectious disease in surgical patient is an infusion of antibiotics, although an effect of antibiotics has been deteriolated in chronic status. Therefore many clinician has used combined therapy of antibiotics and anti-inflammatory drugs such as adrenal cortical hormone or non-steroid anti-inflammatory drugs. Adrenal cortical hormone has not been used due to a lots, of compltcations of gastro-intestinal tract and brain. Acetylsalicylic acid and phenylbutazone has long been used as anti-inflammatory drugs. Phenylbutazone derivatives are activated by -acid base, while Solantal is activated by alkali base, which has been made at Fuzizawa Pharmaceutical Co. as benzothiazoline derivatives, namely Tiaramide. Clinical studies of Solantal has been made with 45 patients at Surgical. department of National Medical Center, Seoul, Korea. Most of patients were able to take of food early after surgery. Average daily dosage of Solantal were ranged from 300mg to 600mg for shortest 3 days to 20 days. It has been effected against pain-after surgery with 70~80%. In anti-inflammatory effect, it could not been studied by difficult measure of Solantal effect in surgical patient. Side reaction of Solantal was minimal. with gastrointestinal trouble(0.5%) and itching sensation(0.2%). There has been nothing of complication during long standing use.
잔디 초지의 쥐불이 인접한 논의 절지동물군집의 동태에 미치는 영향
이학섭,장남기 한국잔디학회 1990 한국잔디학회지 Vol.4 No.2
Effects of Zoysia japonica fired in winter on the arthropoda communities in its grassland and rice field was investigated . The results gave indicated that a significant difference between total 15,120 individuals of 4 classes, 11 orders, 47 families, 92 genera and 103 species in the control of Zoysia japonica grassland, and total 1, 404 individuals of 4 classes, 11 orders, 47 families, 53 genera 65 species in the Zoysia japonica grassland fired in winter. Index of similarity of Zoysia japonica grasslands between Kimpo and Yangsuri areas was 0.51. Dominant species of arthropoda communities in Zysia japonica grasstands in Kimpo and Yangsuri areas were Hypogastnua sp. and Proisotorn sp., respectively. The spiders were 9 families and 27 species at Kimpo, and t2 families. and 44 species at Yangsuri, and their dominant species was Gnathonariurn dentaturn at two areas. Laodelphex striatelus in the Zoysia japonica grassland fired in winter was sampled constantly morning, noon and night, hut Gnatlzonariun dentatum was sampled more frequently in the morning than at night. Damage of the spiders in the Zoysia japonica granssland fired in winter was more severe than that of Laodelphcx striatelus .
카드뮴中毒으로 因한 白鼠睾丸 組織의 變化와 마늘의 防禦效果
李鶴燮,裵恩相,車喆煥 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.3
The garlic contains, along with many kinds of organic compounds, some allylsulfides, amino acids, thiolactic acid, glutathione and some vitamins has expected to yield the effect of detoxication of heavy metal poisoning by forming thiochelate compounds when reacting with heavy metals in bodies. To examine this hypothesis, especially for the effect of garlic on the detoxication of Cd-poisoning in testis, one of the most sensitive target organs of Cd-poisoning, a total of 60 albino rats were sampled as experimental animals and devided into six group: a group given with only 100ppm cadmium; one given 3.35% garlic; two groups given with 1.70% and 6.67% garlic in addition to 100ppm cadmium; one given 400ppm garlic oil and a group of controls. After rearing the rats with different meals and water as indicathe above for 12 weeks, alkaline phosphatase activity, cadmium content in testis and pathological changers in testicular tissue were measured and observed to have following results; The group given with 6.67% garlic in addition to 100ppm cadmium showed significant decrease of toxic changes due to cadmium poisoning in terms of alkaline phosphatase activity, cadmium accumulation in testis, and pathological change of testicular of testicular tissues. On the other hand, the group given 100ppm cadmium only showed significantly higher cadmium in testis, more decrease of alkaline phosphatase activity and definite pathological findings of hydropic degeneration and necrosis with atrophy n seminiferous tubules and degenerative changes in germinal epithelium of testis. The group given with 400ppm garlic oil in addition to cadmium showed in midline reaction in every above toxic changes.
보툴리눔 신경독소의 세포기반 역가시험법의 최근 연구 동향
이학섭 ( Hak Sup Lee ),김윤영 ( Yoon Young Kim ),장성수 ( Sung Su Jang ) 서울대학교 인구의학연구소 2013 人口醫學硏究論集 Vol.26 No.-
Botulinum neurotixins (BoNTs), causative agent of botulism, are the most potent natural toxins mainly produced by bacterium Clostridium botulinum, which is a Gram-positive, rod-shaped and obligate anaerobe. BoNT serotypes A and B are wildely used as pharmaceuticals to treat diverse neurological diseases and for cosmetic purpose. To date, gold standard essay for a measurement of BoNTs` Potency is the mouse LD50 (50% lethal dose) bioassay. This is the only potency assay approved by the FDA. Mouse LD50 bioassay, however, causes not only large error but high cost, and it also requires large number of mice and trained person who handles the procedure. In this reason, there is a need to develop a reliable assay in order to replace the mouse LD50 assay. An alternative assay capable of including full biological activity of BoNTs is cell based assay. In this review, we will summarize advantages and limitations of various BoNTs potency assays, focusing on cell based assays.
이학섭 ( Hak Sup Lee ),김윤영 ( Yoon Young Kim ),장성수 ( Sung Su Jang ) 서울대학교 인구의학연구소 2011 人口醫學硏究論集 Vol.24 No.-
Pain is the general symptom encountered in a diversity of diseases. Although pain mechanisms are nor fully understood, hyperexcitability of primary sensory neurons can lead to abnormal burst associated with pain. After injury to their axons, sensory neurons can show excitability by increased voltage-gated sodium ion channel expression and abnormal accumulation. Therefore, sodium channel blockers may be effective analgesics in the management of pain such as neuropathic pain, Also, tetrodotoxin (TTX), non-peptide neurotoxin produced by bacteria living within organs of marine organism such as puffer fish, is a potent sodium ion channel blocker, and thus, TTX is a promising material for the treatment of various types of pain. In this review, we will summarize the biological properties of sodium ion channel and subtype specific sodium ion channel blockers, and finally review the TTX research in pain relief.