Naegleria fowleri가 자연살세포의 활성에 미치는 영향

李圭來(Kyu-Rae Lee),愼珠沃(Chu-Og Shin),任敬一(Kyung-il Im) 대한기생충학열대의학회 1991 The Korean Journal of Parasitology Vol.29 No.3

가족적응력 결속력 평가척도(FACES Ⅲ)를 사용한 예비역 장교의 가족기능 특성에 관한 연구 - 요인구조 및 가족기능의 변화 -

이장희 ( Jang Hee Lee ),이규래 ( Kyu Rae Lee ),이석중 ( Seok Joong Lee ) 국군의무사령부 1993 대한군진의학학술지 Vol.24 No.1

보행 실조, 복시 증세로 나타난 알코올성 베르니케 뇌병증

고기동(Ki Dong Ko),이윤택(Yoon Taek Lee),이현(Hyun Lee),황희영(Hee Young Hwang),김경곤(Kyoung Kon Kim),서희선(Heuy Sun Suh),황인철(In Cheol Hwang),이규래(Kyu Rae Lee) 대한임상노인의학회 2017 대한임상노인의학회지 Vol.18 No.1

Wernicke’s encephalopathy is an acute, reversible neurologic disorder which arises as metabolic complication of thiamine (vitamin B1) deficiency, frequently associated with alcohol misuse. Although Wernicke’s encephalopathy is characterized by a classic triad of mental status changes, ataxia, and ocular motor abnormalities, heterogenous clinical manifestations are more common. Prompt and accurate diagnosis by clinical suspicion is important to avoid death or progression to Korsakoff syndrome with irreversible brain damage. Immediate supplementation of thiamine is the cornerstone of treatment despite no accepted consensus on the optimal regimen. In this case report, we describe a case of Wernicke’s encephalopathy, which presentd with typical symtoms in a 63-year-old man with chronic alcoholism and review related literature.

원저 : 비만환자 치료시 푸링 정의 유효성 및 안정성 평가를 위한 연구

서희선 ( Heuy Sun Suh ),이선녀 ( Sun Nyu Lee ),최준영 ( Jun Young Choi ),김상만 ( Sang Man Kim ),이규래 ( Kyu Rae Lee ) 대한비만학회 2004 The Korean journal of obesity Vol.13 No.4

원저 : 모발조직 마그네슘 농도와 비만 연관변수와의 연관성

서희선 ( Heuy Sun Suh ),장소영 ( So Young Chang ),최준영 ( Jun Young Choi ),이선녀 ( Sun Nyu Lee ),이규래 ( Kyu Rae Lee ) 대한비만학회 2005 The Korean journal of obesity Vol.14 No.1

연구배경: 비만은 만성 질병과정의 하나로 인식되어 혈중 저마그네슘증과 연관있는 것으로 알려져 있다. 그러나 99%이상의 마그네슘이 세포내에 존재한다는 사실에 비추어 볼 때 세포외 혈중 마그네슘 측정은 정확도가 떨어지므로 이에 비교적 검체 수집이 용이하며 세포내 조직수준에서의 마그네슘 농도를 측정할 수 있는 모발조직 미네랄 검사를 이용해서 건강한 여성에서의 모발 조직 마그네슘 농도와 비만 연관변수와의 연관성을 알아보았다. 방법: 고혈압, 당뇨병, 심혈관계 Background: The obesity was recognized the one of chronic inflammtory diseases and known as relating to the serum hypomagnesemia. But the above 99% of total magnesium exist in intracelluar area, serum extracelluar magnesium is not a accurate method. In He

실제적인 비만 치료 교육을 위한 역할극의 시도

이지선,이규래,윤상렬,유형준,김용성 대한비만학회 1999 The Korean journal of obesity Vol.8 No.2

Role play has several synonyms; Drama Games, Drama techniques, Child drama (Childrens the-atre), Dramas method, Educational drama and so on. It is a kind of exercise where the student is assigned a fictitious role from which he has to improvise some kind of behaviour toward the other role characters in the exercise. Also, there are included pleasure and learning. Enjoyment provides an outlet for self-expression and helps the development of imagination and artistic awareness; increases social awareness, mental awareness, fluency of speech, self-knowledge, self-respect, self-displine and self-confidence the opportunity to learn how to co-operate with others and helps develop orderly thinking and the abililty to organize improves physicial co-ordination and physical fitness have a therapeutic effect, through helping student to deal with their real life problems or a cathartic effect, by enabling them to act our violence and frustration social and moral training, and helps young people to mature emotionally, preparing them for adult life learn from observing others. As you know, behavioural treatment is a core of therapeutic modalities in obesity patients. Its a process to modify their thinking and attitude to desirable way. Then role-play is a kind of learning process by showing the certain situational play. So we tried to improve the therapeutic ability on education of obesity patient in outpatient clinic, by performing this. Strictly speaking, this trial is not the real role-play. Some like a slide presentation, some like a play. Besides, there would be found so many faults in doing so. Nevertheless, the trial like this will have to go on. Finally, we appreciate for the Korea Society for the Study of Obesity.

식사 대용식을 사용한 단기간의 체중 조절 : 한국인 비만 성인 여성에서 식사 대용식에 대한 연구 Meal replacements trial in Korean Obese women

이복기,이규래,박미현 대한비만학회 2002 The Korean journal of obesity Vol.11 No.2

연구배경 : 최근의 비만 인구의 증가와 체중 조절에 대한 관심이 증가하면서 식사 대용식의 사용이 많아지고 있다. 그러나 이러한 제품들이 실제적인 효과 면에서 문제가 되고 있음이 많이 보고되고 있고, 무분별한 사용으로 경제적인 측면에서 많은 손실이 초래되고 있음이 현실이다. 이에 본 논문은 비만 여성에 대한 식사 대용식에 대한 연구를 함으로써 국내에서 시판되는 식사 대용식의 효능과 안전성에 대해 알아보고자 하였다. 방법 : 대중 매체 및 인터넷 사이트를 통하여 자원한 여성들 중 체질량 지수 25kg/㎡ 이상의 25 ~ 35세의 여성 54명을 선별하여 6주간의 연구가 진행되었다. 참여한 54명을 2군으로 분류하여 식사 대용식 사용군 (A군)은 식사 대용식을 아침과 저녁 식사에 사용하였고 대조군 (B군)의 경우는 식사와 운동에 대한 교육만을 시행하였다. 모든 연구 대상자에 대해서 초기 방문과 3주 째, 그리고 6주 째에 신체 계측 치들과 체 성분, 그리고 대사적인 변수들을 측정하고 6주간의 식사일기를 분석하였다. 결과 : 54명의 연구 대상자 중 42명이 6주간의 연구 기간을 마쳤고, 그 중 식사 일기의 분석이 가능한 35명을 최종 대상자로 하였다. 6주의 연구 동안 A군은 1042.61±179.73kcal/day를 섭취하였고 B군은 1313.49±308.07 kcal/day를 섭취하여 두 군간의 통계적으로 의미있는 차이가 있었다. 신체 계측치와 체 성분에 미치는 영향은 A군에서 체중 (-3.84±1.97 kg), 체지방률 (-1.42±2.20%), 허리 둘레, 둔부 둘레에서 의미 있는 감소를 보였고, B군에서는 체중 (-3.39±2.25 kg), 허리 둘레, 둔부 둘레에서 의미 있는 감소를 보였다. A군에서는 수축기, 이완기 혈압, LDL 콜레스테롤에서 의미있는 감소를 보였고, B군에서는 수축기 혈압, 총 콜레스테롤 , LDL 콜레스테롤에서 의미 있는 감소를 보였다. 양군간의 체중과 체지방률의 변화량의 비교에서는 유의한 차이를 보이지 못했다. 결론 : 이 결과는 한국의 성인 여성에서 6주 동안 하루 2번의 식사 대용식을 사용할 때, 섭취량을 줄이고 체중과 체지방률을 줄이는 데 효과적인 방법임을 시사한다. 그렇지만 대조군과의 비교를 위해서는 좀 더 장기간의 연구가 필요하다. Background : Among the obese and those interested in weight reduction, the use of meal replacements recently has gained popularity. The efficacy and safety of meal replacements, however, has been questioned. In addition, the imprudent use of meal replacements lead to significant economic costs. Therefore, this study will investigate the efficacy and safety of meal replacements by examining obese women who take meal replacements. Methods: This experiment was conducted with subjects who volunteered through the internet and the mass media. The duration of the experiment was six weeks. The subjects consisted of 54 obese women (BMI>25) whose ages ranged from 25 to 35.54 subjects were divided into two groups : Group A, the experimental group, took meal replacements for breakfast and dinner. Group B, the control group, received instruction concerning exercises and diets. anthropometric measurement, body composition and metabolic variations were evaluated the first day, the third week and the sixth week; in addition, the subjects' diet diaries were analyzed. Results : 42 out of 54 finished the six weeks experiments. 35 out of the 42 completed diet diaries. The results are based on the 35 subjects' diet diaries. Group A took 1042.61±179.73 kcal/day, and group B took 1313.49±308.07 kcal/day for six weeks. This is a statistically significant difference between two groups. Group A showed a significant reduction in weight (-3.84±1.97 kg), the percentage of body fat (-1.42±2.20%), and in waist and hip circumference. Group B also showed a significant reduction in weight (-3.39±2.25 kg) and in waist and the hip circumference. In group A, there was a significant reduction in the LDL cholesterol and in systolic and diastolic blood pressure. In group B, there was a significant reduction in total cholesterol, LDL cholesterol and in systolic blood pressure. There was no significant difference in changes of weight and body fat between the two groups. Conclusion : From these results, Korean women who took meal replacements twice a day for six weeks reduced their oral intake, weight and body fat. However, long-term studies are needed to clarify the comparison between two groups.

비만증환자에서 소량의 세로토닌 길항제의 체중감량 효과

이규래,이득주,한인권,정호연 대한비만학회 1993 The Korean journal of obesity Vol.2 No.1

신경병성 통증모델쥐에서 산화질소합성효소 억제제가 척수후각세포의 활성도에 미치는 영향

이규래,윤덕미,임중우,곽영섭,정승수,남택상 대한통증학회 2000 The Korean Journal of Pain Vol.13 No.1

Background: Partial nerve injury to a peripheral nerve may induce the development of neuropathic pain which is characterized by symptoms such as spontaneous burning pain, allodynia and hyperalgesia. Though underlying mechanism has not fully understood, sensitization of dorsal horn neurons may contribute to generate such symptoms. Nitric oxide acts as an inter- and intracellular messenger in the nervous system and is produced from L-arginine by nitric oxide synthase (NOS). Evidence is accumulating which indicate that nitric oxide may mediate nociceptive information transmission. Recently, it has been reported that NOS inhibitor suppresses neuropathic pain behavior in an neuropathic pain animal model. This study was conducted to determine whether nitric oxide could be involved in the sensitization of dorsal horn neurons in neuropathic animal model. Methods: Neuropathic animal model was made by tightly ligating the left L5 and L6 spinal nerves and we examined the effects of iontophoretically applied NOS inhibitor (L-NAME) on the dorsal horn neuron's responses to mechanical stimuli within the receptive fields. Results: In normal animals, NOS inhibitor (L-NAME) specifically suppressed the responses to the noxious mechanical stimuli. In neuropathic animals, the dorsal horn neuron's responses to mechanical stimuli were enhanced and NOS inhibitor suppressed the dorsal horn neuron's enhanced responses to non-noxious stimuli as well as those to noxious ones. Conclusions: These results suggest that nitric oxide may mediate nociceptive transmission in normal animal and also mediate sensitization of dorsal horn neurons in neuropathic pain state.

일차의료에서 비만 치료의 실제적 접근

이규래 대한가정의학회 1999 Korean Journal of Family Medicine Vol.20 No.5