Chiari-Frommel 증후군 치료 1예

허필형(PH Hur),조봉춘(BC Cho),최성기(SK Choi),박찬동(CD Park) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.11

The chiari-frommel syndrome is presently taken to refer to postpartum persistent amenorrhea and galactorrhea in the absence of an identifiable intracranial neoplasm. Chiari et al, in 1852 described 2 patient with a syndrome of postpartum galactorrhear, amenorrhea and atrophy of the uterus and ovaries. Frommel in 1882 reported that the incidence of postpartum atrophy of the uterus was less than 1% and associated galactorrhea of these 2men and applying the term chiai frommel syndrome to this combination of clinical findings in 1923. We experienced a patient of typical chiari-frommel syndrome who has been amenorrhea for 4 years and galactorrhea for 4 years and 9 months. It is the purpose of this report with brief literature to describe a patient of chiari-frommel syndrome whom ovulation has been induced by the administration of Regulen-K1 with consequent pregnancy and delivered normal female infant.

전위분만에 관한 임상통계학적 고찰

김대훈(DH Kim),허필형(PH Hur),김기원(KW Kim),한구택(GT Han),전은의(EE Chun) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.6

1. The incidence of the breech presentation was 4.29% (1:23.3) 2. The age distribution was mostly concentrated between the age of 26 and 30 (57.8%). The frequency of the breech presentation was 53.22% in the primipara. 3. As to the gestational weeks, the frequency was mostly concentrated in the primipara between 37 and 40 gestational weeks (30.21%) and the multipara between 37 and 40 gestational weeks (26.0%) respectively. 4. The frank breech incidence was 51.90% complete breech incidence was 25.52% incomplete breech incidence was 20.1% and the compound breech incidence was 2.37%. 5. The prematurity was most common etiological factor and the next frequent factor was multiple pregnancy. The other contributable factors were the CPD, the low birth weight, the growth retardation, the PROM, the placenta-membrane cause and the congenital anomalies respectively. 6. The cesarean section rate was 46.61% and the vaginal delivery rate was 52.39% 7. As to the prognosis of the infants estimated by Apgar score, the depression rate of the infants by vaginal delivery was 3.5 times higher than that of cesarean section delivery and 5 times higher if the fetal weight was over 2500 gm. 8. The corrected perinatal mortality rate was 19.8% in the breech delivery and it was 5.9% in the case of the cesarean section delivery and 5 times higher in the vaginal delivery than in cesarean section delivery. The overall perinatal mortality rate was 5.88% if the fetal weight was over 2500gm

자궁선근증에 대한 임상적 고찰

이우영(WY Lee),허필형(PH Hur),이창석(CS Lee),최인호(IH Choi),김수평(SP Kim) 대한산부인과학회 1980 Obstetrics & Gynecology Science Vol.23 No.8

1974년 1월 1일부터 1978년 12월 31일까지 만 5년동안 가톨릭의과대학 부속성모병원 산부인과에서 시행한 자궁적출술 총 1,007예중 자궁선근증 136예에 대하여 임상 및 병리조직학적 관찰을 하였던 바 다음과 같은 결론을 얻었다. 1. 자궁선근증의 발생빈도는 13.5%이었다. 2. 호발연령은 40세에서 49세였으며, 평균연령은 42.6세이었다. 3. 경산부의 발생율이 미산부보다 7.5배로 높았다. 4. 자궁선근증을 가진 자궁은 정상자궁보다 더욱 그 무게가 증가되었으며, 136예의 3분의 1에 해당하는 예에서 81~120gm의 사이에 있었다. 5. 자궁선근증의 경우 분만회수의 증가에 따라 자궁의 무게도 크게 증가하였다. 6. 전 136예의 5분의 1에 해당하는 예에서는 아무런 증상을 호소하지 않았고, 골반내동통, 월경통, 월경과다등이 주요증상을 이루었다. 7. 수술전 진단의 정확도는 10.3%이었으며, 수술후 육안적진단의 정확도는 22.8%이었다. 8. 합병질환중 자궁근종이 26.5%로 가장 많았고 골반내막증은 8.1%를 보였다. 9. 자궁내막 소견은 증식기가 68.4%, 분비기가 14.0%를 나타냈다. This is the report of a retrospective study of 136 consecutive instances of adenomyosis among 1,007 hysterectomies, identified histologically at the St. Mary`s Hospital of Catholic Medical College during the 5 year period from January, 1974 through December, 1978. The results of clinicopathologic analysis were summarized as follows. 1. Routine pathologic examination of the 1,007 uteri revealed with adenomyosis in 136 specimens, and incidence of 13.5%. 2. The highest age incidence was in 40 to 49 years of age group, an incidence of 55.9% and the mean age was 42.6 year old. 3. Adenomyosis was more likely to occur in the parous woman than non-parous woman, such as 88.2% and 11.8% respectively. 4. A uterus containing adenomyosis weighs on the average more than a normal uterus, the most prevalent uterine weight was from 81 gram to 120 gram, an incidence was 35.2%. 5. The correlation of uterine weight and parity in adenomyosis was parallel, that is, more weight in higher parity. 6. Nearly one-fifth of the 136 patients analyzed for this report had proffered no symptoms of adenomyosis, an incidence of 19.1%. 7. Pelvic pain, dysmenorrhea, and menorrhagia were the common symptom of adenomyosis, an incidence of 38.2%, 33.8% and 31.6% respectively. 8. Only 14 of the 136 patients(10.3%) showed a preoperative diagnosis of adenomyosis. 9. Thirth-one patients(22.8%) in this study were diagnosed as adenomyosis postoperatively by surgeons. 10. Myoma was the most common associated lesion in adenomyosis, an incidence of 26.5%. 11. External endometriosis was found in 8.1% of cases in this study. 12. Proliferative endometrium was the most frequent endometrial finding of adenomyosis, an incidence was 68.4%.

뇨중 융모성 성선자극 호르몬 측정과 초음파 단층 촬영을 이용한 절박유산의 예후 판정

이진우(JW Lee),허필형(PH Hur),나종구(Rha CG),최성기(SK Choi) 대한산부인과학회 1977 Obstetrics & Gynecology Science Vol.20 No.1

저자들은 20예의 절박유산 유산군 환자와 5예의 대조군 환자에서 뇨중 hCG 측정 및 초음파 단층촬영을 병용하여 예후 관찰을 시도한 바 다음과 같은 결론을 얻었다. 1. 대조군 5예에서의 24시간 뇨증 hCG 34 측정값중 32 측정값이 Wide(1962)의 정상범위 이내에 존재하였으며 태낭직경 16측정값중 15측정값, 아두대횡경 20측정값중 18측정값이 Hellman(1969)의 정상범위 이내에 존재하였다. 2. 절박유산 20예중 임신주수에 따른 24시간뇨중 hCG 측정값과 초음파 단층촬영에 의한 태 낭상이 모두 정상인 6예의 경우는 전예에서 정상 임신 과정을 밟았다. 3. 24시간뇨중 hCG 측정값은 정상이면서 초음파단층 촬영에 의한 태낭상이 비정상인 경우 4예중 1예가 유산되고 3예에서 정상임신의 과정을 밟았다. 4. 24시간뇨중 hCG측정값은 비정상이면서 초음파 단층촬영에 의한 태낭상이 정상인 5예중 2예에서 유산이 되고 3예에서 정상임신의 과정을 밟았다. 5. 24시간뇨중 hCG측정값 또는 초음파단층촬영 소견중 일측이 정상범위 밖에 있던 9예중 6 예에서 정상임신의 과정을 밟았다. 더우기 이를 6예중 1예에서 전자의 값이 임신 7주에 서 7,800 IU/L로 정상이하의 낮은 값을 보인예도 있어 초음파 단층촬영과 함께 뇨증 hCG 의 반복 추적검사가 절대로 필요하다고 생각된다. 6. 임신 주수에 따른 hCG의 측정값과 초음파 단층촬영소견이 모두 비정상적인 5예의 경우는 전예에서 유산이 되었다. 7. 이상의 성적을 종합컨데 임상에서 신속간편하게 사용할 수 있는 뇨중 hCG 측정법과 초음파 단층촬영법을 병용하면 두 방법의 결함을 상호 보완함으로서 절박유산의 진단 및 예후 판정, 치료방침의 결정 등에 많은 도움을 줄 수 있으리라 생각되며 예후 판단에 필요한 측정값의 정확한 기준을 정하기 위해서는 좀더 측정대상을 확대하여 연구함이 필요하다고 생각된다. In threatened abortion fetal health and growth in utero has been assessed by several methods. Various hormonal concentrations produced by placenta including human chorionic gonadotropin(hCG), progesterone, estrogen, human placental lactogen(hPL) and their meta bolites in urine have been estimated. In addition morphological estimation of fetal growth by X-ray and morphological has been carried out. But hormonal and morphological studies mentioned above were not always conclusive in making a definitive estimation of prognosis in threatened abortion. The present study was designed to combine two selected methods of approach, i.e., estimation of urinary hCG as a barometer of placental physiology and ultrasonography as morphological estimation of fetal growth in utero. Twenty patients clinically diagnosed of threatened abortion and five clinically normal pregnant women as control group were evaluated throughout their entire course of pregnancy. The titers of urinary hCG and the ultrasonographic patterns of fetal growth were measured serially once a week until their clinical symptoms of threatened abortion ceased and compared with their ultimate outcome of pregnancy. The regression curve of urinary hCG titer estimated by Wide (1962) and that of growth of gestational sac and fetal head estimated by Hellman et al. (1969) were used as standard one. Each measurement of urinary hCG titer (6-20 weeks of gestation) was interpreted as normal or abnormal value according to the confidential limits described by Wide (1962). Each measurement of gestational sac (6-12 weeks of gestation) or biparietal diameter (12-20 weeks of gestation) was also interpreted as normal or abnormal value according to normal range described by Hellman(1969). Then twenty patients of threatened abortion were divided into four groups according to various interpretations of both measurements, and were compared with the course of control group in relation to ultimate outcome of pregnancy. The results were as follows: 1) In control group of 5 normal pregnancies all 32 measurements of urinary hCG titer except two were within confidential limits described by Wide (1962). And all 15 measurements of growth of gestational sac except one and all 19 measurements of growth of biparietal diameters except two were within normal limits described by Hellman et al (1969). 2) All those 6 patients who revealed normal values of both urinary hCG titer and ultrasonographic measurements ended in normal course of pregnancy. 3) While three of those who revealed normal values of urinary hCG titers with abnormal ultrasonographic measurements completed their pregnancies in normal term delivaries, one of them aborted. 4) While three of those who revealed abnormal values of urinary hCG titers with normal ultrasonographic measurements resulted in normal deliveries, two of them aborted. 5) All those who revealed abnormal values of both urinary hCG titers and ultrasonographic measurements ended in abortion. 6) For more reasonable assessment of the prognosis in threatened abortion we think it better not only to use both methods together than any single one but also to check serial measurement.

산부인과 질환에서의 섬유소 용해효소의 변동

황순경(SK Whang),김창이(CY Kim),허필형(PH Hur),나종구(Rha CG),이헌영(HY Lee) 대한산부인과학회 1977 Obstetrics & Gynecology Science Vol.20 No.9

1) 정상임신부에서 섬유소 용해효소는 비임신부에 비해 임신중에 현저히 증가되나 분만중과 분만후에는 점차적으로 감소한다. 2) 자간증 및 중증 전자간증 환자에서는 플라스미노젠의 전량이 정상임신부에 비해서 임신중, 분만중과 분만후 모두 낮은 수치를 보여주었다. 3) 산후출혈 환자에서는 섬유소 용해효소가 정상분만 산모에 비해서 현저히 낮은 수치 를 보였다. 4) 기능성자궁출혈환자에서는 플라스미노젠의 감소가 현저하였고 2예중 1예에서는 활 성플라스민이 검출되었다. 5) 패혈성 복막염환자에서 섬유소용해효소가 거의 소모되었음을 알 수 있었다. This experimental study was planned to detect the changes of fibrinolytic system in the obstetric and gynecological patients. In this strdy, ENZO-DIFFUSION, fibrin plate Test was used to examine the 3 components of fibrimolytic system; available plasmin (fibrinolytic potential), active plasmin (fibrinolysin) and total plasminogen (profibrinolysin). The results were as follows; 1) In normal pregnancy, profibrinolysin was markedly increased in alte pregnancy, and then gradually decreased in labor and after delivery. fibrinolysin was not detected and fibrinolytkc potential was normal in level in late pregnancy and labor and after delivery. 2) In pre-eclampsia and eclampsia; Fibrinolytic potential was normal in level and fibrinolysin was not detected in late pregnancy, in labor and after delivery. But profibrinolysin was less than that of normal pregnancy. 3) In patient with postpartum hemorrhage, profibrinolysin was markedly reduced in level compared to normal postpartum woman. But fibrinolytic potential was normal in level and fibrinolysin was not detected. 4) In two patients with dysfunctional uterine bleeding, although fibrinolytic potentkal was normal in level, profibrinogen was markedly decreased in % activtty and in one of these, fibrinolysin was detected. 5) In a patient given radical hysterectomy for carcinoma of cervix, profibrinolysin was reduced and fibrinolysin was detected on the lst postoperative day. 6) In a patient with hyaline degeneration and suppuration of myoma uteri and panperitonitis profibrinolysin could not be detected pre-and postoperatively, and also, fibrinolytic potential was absent.

만삭임신에서 거대난소암의 자연파열 1예

김명서(MS Kim),정재근(JK Jung),함재홍(JH Ham),허필형(PH Hur) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.6

저자들은 1979년 1월 가톨릭의과대학부속 성모자애병원에서 수술후 병리학적으로 확진된 난 소의 점액소성낭선암의 자연파열과 자간을 수반한 만삭임신의 1예를 경험하였기에 간략한 문헌고찰과 아울러 증례를 보고하였다. Primary ovarian carcinoma associated with pregnancy is quite uncommon. In view of its rarity, complications and policy of the management of mother and fetus, it could offer real problems in clinical practice. After presenting a clinical history of the following case, a review of the previously reported cases of ovarian cancer, including benign ovarian tumor, in pregnancy is represented.

미숙분만시 Cortisol값과 특발성 호흡장애증후군과 비교관찰

최인호(IH Choi),김영일(YI Kim),이준모(JM Lee),허필형(PH Hur),이진우(JW Lee) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.1

미숙분만시 발생된 IRDS와 미숙아의 제대혈증 cortisol값의 관계를 규명하기 위하여 만삭분 만 산모 20 예와 미숙분만 산모예를 대상으로 모체혈중 및 제대혈중의 cortisol의 변동을 측 정관찰하여 다음과 같은 결과를 얻엇다. 1. 미숙아 제대혈중 cortisol값은 정상대조군 보다 낮았으며 IRDS 환자군은 IRDS가 발생하지 않은 미숙아군보다 낮았다. 2. 미숙분만의 모체혈중 cortisol값은 미숙아군의 제대혈중값보다 현저히 높았으나 IRDS 발생 여부와는 무관하였다. 3. 전체적으로 모체혈중 cortisol값이 증가함에 따라서 신생아의 제대혈중 cortisol값이 증가하 였으나 IRDS 환아군에 있어서는 통계적으로 상관관계를 볼 수 없었다. 4. IRDS 환아군 및 IRDS가 발생하지 않은 미숙아군의 제대혈중 cortisol값은 분만방법 및 신 생아의 체중과는 무관하였다. 이상의 성적으로 미루어보아 미숙아의 IRDS 발생시는 자궁내 태아혈중 cortisol값과 밀접한 관계가 있는 것으로 사료된다. For the purpose of evaluating certain relationship of idiopathic respiratory distress syndrome (IRDS) wiht cortisol levels of maternal and cord serum in premature delivery, those of 20 normal term and 41 premature delivery were measured by RIA and those data were evaluated in the view points of cortisol levels , method of delivery and neonatal body weight. The results were as follows. 1. cord cortisol levels in premature infants were significantly lower than normal mature infants and those in premature infants with IRDS were lower than those without IRDS. 2. maternal serum cortisol levels in premature delivery were higher than those in premature infant`s cord serum regardless of IRDS 3. The cord cortisol levels gradually increased along with increasing maternal serum cortisol levels but this was not true in IRDS group. 4. cord cortisol levels of premature infants with or without IRDS were affected neither by method of delivery nor by neonatal body weight. considering above results , it can be imagined that the development of IRDS may be closely related with fetal serum cortisol levels but more extensive hormonal study is nesessary to obtain more acurate conclusion.

화학요법치료에 "최소저항"을 갖는 융모성 질환의 임상연구

이동욱(DW Lee),배석년(SN Bae),김종복(CB Kim),강병철(BC Kang),허필형(PH Hur),김승조(SJ Kim) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.6

1973년 1월부터 1982년 5월까지 카톨릭의과대학부설 융모성질환연구소에 등록 화학요법치료를 받은 융모성 질환 340예중 혈청 β-hCG값이 경쾌수준에 거의 도달 했으나 화학요법치료를 4회 이상 계속해도 20mIU/ml 이하값에서 "plateau"를 보이는 "최소저항군"의 연구조 사 결과 다음과 같은 결론을 얻었다. 1. 화학요법치료를 받은 융모성질환 340예중 "최소 저항군"은 31예(9.1%)였다. 2. "최소저항군" 31예중 화학요법치료를 중지한 6예 의 예후는 재발이 4예(66.7%), 경쾌가 2예(33.3%)로 서 이점주의 2/3가 잔여종양이며 1/3이 경쾌된 것으로 판단되었으며, 융모성질환의 경쾌판정기준의 절대성을 의심케 했다. 3. "최소저항군" 31예중 계속적인 화학요법제 치료 는 25예였으며, 동일한 화학요법제치료가 17예, 다른 화학요법제 치료로 전환한 것이 8예였고, 전예의 경우 경쾌는 15예(88.2%), 후예의 경우 경쾌는 8예(100.0 %)로써 약제내성군의 치료원칙에 따른 화학요법제 전 환이 예후가 좋았다. 4. "최소저항군"의 소인이외는 위험인자를 규명하기 위한 조사결과는 다음과 같다. (1) 환자의 연령은 "최소저항군"의 빈도에 영향을 미 치지 않았다. (2) 기왕분만회수는 "최소저항군"의 빈도에 영향을 미치지 않았다. (3) 혈액형이 AB형인 경우 "최소저항군"의 빈도가 높았다. (4) 선행임신은 "최소저항군"의 빈도에 영향을 미치 지 않았다. (5) 종양위 진행기간이 7개월이상인 경우 "최소저항 군"의 빈도가 높았다. (6) 혈청 β-hCG값이 높을수록 "최소저항군"의 빈도 는 증가했다. (7) 자궁의 크기는 "최소저항군"의 빈도에 영향을 미치지 않았으나 전자궁적출술을 시행한 경우 그 빈도는 현저히 높았다. (8) 골반강전이가 다른 장기전이에 비해 "최소 저항 군"의 빈도가 높았다. (9) 치료목적으로 사용한 기왕화학요법실패시 "최소 저항군"의 빈도가 높았다. (10) 세포면역반응을 위한 DNCB검사가 낮은 반응을 보일수록 "최소저항군"의 빈도가 높았다. (11) Methotrexate 와 Actinomycin-D의 복합치료경 우 다른 화학요법치료에 비해 "최소저항군"의 빈 도가 높았다. (12) Stage II 융모성질환에서 "최소저항군"의 빈도 가 높았으나 위험군별 분류는 그 빈도에 영향을 미치지 않았다. 5. 본 연구는 저자들이 "최소저항군"이라 명명한 융 모성질환의 한 범주를 임상고찰한데 지나지 않고 그정 의의 타당성 및 경쾌판정 기준에 관한 연구는 계속되 어야할 것으로 사료되며 아울러 hCG β-submit와 다 른 호르몬과의 교차반응문제 혹은 다른 세포수준에서 의 hCG분비등의 보고를 주시하여야 할 것이다. ln order to investigate risk factors of minimum resistance cases, 31 cases were selected from 340 patients of trophoblastic disease with chemo therapy registered at Korea lnstitute of Triophoblastic Disease in Catholic Medcal School from January, 1973 to May, 1982. The study group revealed 1.5~2.0mIU/ml of serum β-hCG value for 4 consecu­ tive weeks although they revealed remission level(below 1.5mIU/ml) for 3 consec- utive weeks. ln this study, the group was named minimum resistance to be differ- entiated from persistent.trophoblastic disease or drug resistance and was compared with controlgroup of 252 cases of trophoblastic disease with remission except 31 cases of minimum resistance and expired 51 cases. Among this study group, 17 cases were treated with continuous chemotherapy with same regimen and remission rate was 88.2% (15 cases), and 8 cases were treated with continuous chemotherapy with switching regimen and remission rate was 100% (8 cases). Chemotherapy was discontinued in 6 case and remission was revealed in 2 cases(33.3%) Of them. Residual tumor was revaled in 66.6% of min- imum resistance cases. ln comparison of statistical results between control group and study group, authors obtained the result that risk factors of minimum resistance were affected by long period of tumor age, AB type of ABO blood group, failed preⅵous therapeutic chemotherapy, previous initial hysterectomy, DNCB negative, and combination chemotherapy of Methotrexate and Actinomycin-D.

Thanatophoric Dwarfism을 동반한 다발성 기형 1 예

최광호(KH Choi),조형우(HW Chow),안웅식(WS An),허필형(PH Hur) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.15

가톨릭 의과대학 부속 성모자애병원에서 임신 36주의 경산부에게나 분만한 태아에 thanathophoric dwarfism과 양수과다증, 연골형성세포발육부전증, 요도페쇄, 총배설강막폐쇄 및 기타 다른 기형을 동반한 다발성 기형 일례를 경험하였기에 보고하는 바이다. Thanatophoric dwarfism is a short limbed dwarf condition in which respiratory distress is responsible for death in the first hours or days after birth. Its radiographic features are markedly flattened vertebral bodies with a characteristic pattern of deformity, a characteristically shaped flat squat pelvis, and short bowed bones of the extremities with flaring and irregularity of the metaphyses differentiate this condition from the other recongnized congenital short limbed dwarf condition. We present a case of thanatophoric dwarfism with multiple anomaly based on grossly, radiological & autopy findings with review of the literatures.

Prostaglandin E1 투여에 의한 유도분만에 있어서의 혈중 스테로이드 및 단백질호르몬의 변화

김경태(KT Kim),이우영(WY Lee),정민섭(MS Chung),허필형(PH Hur),이진우(JW Lee) 대한산부인과학회 1980 Obstetrics & Gynecology Science Vol.23 No.2

결론 임신 말기의 산모에게 PGE2를 매시간 1정씩 6회 경구 투여하여 산모 형중의 스테로이드 및 단백 호르몬에 미치는 영향을 관찰하 기 위하여 자연분만 산모 40예와 PGE2 유도분만 성공산모 52예 및 PGE2 유도분만 실패산모 20예에서 분만 경과의 시간에 따른 혈중 progesterone, estradiol, cortisol, hCG b-Subunit 및 hPRL의 변동을 측정 관찰하여 다음과 같은 결과를 얻었다. 1. 자연분만 산모에서 혈중 progesterone은 진통 시작후 3시간 까지 증가한 후 분만시 까지 감소하였고, 혈중 cortisol은 진통 이 경과함에 따라 점점 증가하였으며 estradiol, hCG b-subunit 및 hPRL은 변동이 없었다. 2. PGE2 유도분만 성공삼모에서는 자연분만 산모와 비슷한 호르몬의 변동을 보였다. 3. PGE2 유도분만 실패 산모에서는 유의한 호르몬의 변동은 없었다. 4. PGE2 투여후의 혈중 estradiol값은 PGE2유도분만 성공 산모에서 실패 산모보다 유의하게 높았다. 5. 이상의 관찰로 미루어 PGE2경구 투여로 유도분만이 성공된 산모에서는 자연분만과 비슷한 혈중 호르몬 변동을 보여주었고 진 통 유발시의 혈중 호르몬 변화와 기전도 유사한 것으로 사려된다. In order to measure the effect of oral prostagkandin E2(PGE2) on the serem level if steroid peotein hormones during labor of term pregnant woman PGE2 tablets (0.5mg) were administered orally six times with hourly interval to women in their full term period of pregnancy for induction of labor, and observations were made on the changes of serum level of progesterone, estradiol, cortisol, hCG b-xubunit and hPRL in 52successful cases, 20 unsuxxessful cases of PGE2-induction and 40 cases of spontaneous labor for comparison. 1. Serum progesterone of the women of spontaneous labor increased initially for 3 hours from the onset of labor and then decreased until the time of delivery, while the serum cortisol showed continued increase with the lapse of time. There was no significant change in serum estradiol, hCG b-subunit and hPRL. 2. In the successful cases of PGE2-induction, pattern of hormonal changes were quite similar te those of the women of spontaneous labor. 3. No significant hormonal change was observed in the group of unsuccessful cases of PGE2-induction. 4. The values of serum estradiol were significantly higher in those of successful PGE2-induction than in those of unsuccessful one. 5. From the above findings, it can be concluded that the successful cases of PGE2-induction show aimialr hormonal changes to those of spontaneous labor, and the change as well as mechanism of the hormones during are also similar.