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기관지 천식 환자에서 혈청 IL - 6 , ICAM - 1 , RANTES 농도 측정의 임상적 의의
최재선(Jae Sun Choi),이병훈(Byung Hoon Lee),안창혁(Chang Hyuk Ahn),유지훈(Ji Hoon Yoo),나문준(Moon Jun Na),김재열(Jae Yeol Kim),박인원(In Won Park),최병휘(Byung Whui Choi),허성호(Sung Ho Hue) 대한내과학회 1998 대한내과학회지 Vol.55 No.5
N/A Bronchial asthma is a chronic airway inflammation disorder involving lymphocyte activation and various cytokines secretion by lymphocyte. The inflammatory response results from a complex network of interactions between inflammatory cells (mast cells, eosinophils, macrophages) and resident cells belonging to the lung structure itself like EC, fibroblasts, or bronchial epithelial cells. IL-6 which is known to up-regulate the endothelial cell expression of adhesion molecules participating in the development of the inflammatory reaction in bronchial asthma is produced by alveolar macrophage. ICAM-1 is produced by bronchial epithelial cell and expression by endothelial cell, which is known to enhance of the influx of various cells, RANTES which is known to a potent chemoattractant for eosinophils, lymphocytes, and monocytes, a member of the CC chemokine family, is expressed by bronchial epithelial cell. To evaluate whether markers of lymphocyte activation are useful markers of disease activity in bronchial asthma, we measured slL-6, sICAM- 1, sRANTES in 42 patients with mild to moderate bronchial asthma and in 26 normal controls and con the result with other disease activity markers in asthma(pulmonary function, blood eosinophil counts). The mean level of sIL-6 was higher than that of normal control and correlated significantly with sICAM-1, FEV1% to predicted value. The mean level of sICAM-1 was higher than that of normal control and correlated significantly with FEV1%, FEV1% to predicted value. The mean level of sRANTES showed the tendency to be higher than that of normal control, but not significant statistically, and did not correlated with sIL-6, sICAM-1, FEV1%, FEV1% to predicted value, blood eosinophil counts. It appeared that sIL-6 and sICAM-1 could be a disease marker in bronchial asthma. But, clinical application of the measurement of these markers needs to be studied further.
기관지 천식 환자에서 기도과민성과 혈청 soluble CD25 및 soluble CD23과의 연관성
박용범(Yong Bum Park),유지훈(Ji Hoon Yoo),지현석(Hyun Suk Jee),박성진(Sung Jin Park),김재열(Jae Yeol Kim),박인원(In Won Park),차영주(Young Joo Cha),최병휘(Byoung Whui Choi),허성호(Sung Ho Hue) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.2
N/A Background: Bronchial asthma is a chronic airway inflammatory disorder involving lymphocyte activation. Lymphocytes express various surface markers upon activation, including CD25 (IL-2 receptor α) on T cells and CD23 on B cells. Objectives : To evaluate whether the surface markers of activated lymphocytes are useful indicators of the disease activity in bronchial asthma. Method: We measured serum sCD25 and sCD23 in 42 patients with mild bronchial asthma, and in 26 normal control, volunteers. They were compared with other markers in asthma(methacholine PC20, pulmonary function, total IgE, blood eosinophil counts). Results : Levels of sCD23 were higher among patients than among normal controls and they correlated significantly with sCD23, and FEV1%, but, not with methacholine PC20. Levels of sCD23 were not higher among patients than among normal controls and did not correlate with methacholine PC20, pulmonry function and total IgE level. Conclusion: It appears that sCD25 is related to airway obstruction in bronchial asthma. But, the clinical implications of these markers should be further examined.
기관지천식 환자의 혈중 eosinophil cationic protein 치와 기관지과민성과의 관계
유지훈,최재선,안창혁,이병훈,나문준,김재열,박인원,최병휘,허성호 ( Ji Hoon Yoo,Jae Sun Choi,Chang Hyuk Ahn,Byung Hoon Lee,Moon Jun Na,Jae Yul Kim,In Won Park,Byung Whui Choi,Sung Ho Hue ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Background: Serum eosinophil cationic protein(ECP) level has been proposed as a indirect marker of eosinophilic inflammation of the airway in bronchial asthma. Objective'. To evaluate serum ECP against indirect clinical markers of disease, we compared bronchial obstruction, bronchial hyperresponsiveness and peripheral blood eosinophil counts, total IgE with serum ECP levels in patients with bronchial asthma and normal controls. Method: Fourty-two patients with bronchial asthma and twenty-six normal controls were enrolled. Measurement were made by spirometry, inhalation challenge with methacholine, peripheral blood eosinophil counts, total IgE and FEIA(fluoroenzymatic immunoassay) of serum ECP Result. Serum ECP levels were significantly higher in asthmatic patients than normal controls(p<0.0,5). Serum ECP levels were correlated with peripheral blood eosinophil counts(p<0.01, r=0.544) and bronchial hyperresponsiveness(PC,)(p<0.01, r=-0.456) in patients with bronchial asthma. Serum ECP levels were correlated with degree of bronchial obstruction(FEV, % to predicted value, FEV1/FVC%) in total subjects, but not in asthmatic patients. Conchcsion.' Serum ECP level may be used as indicator of disease activity in bronchial asthma and be helpful in differentiation between normal person and asthmatic patients on simple serological method. Further studies on the changes of serum ECP levels according to disease course and therapeutic responses are needed.
기관지천식 환자에서 Disodium cromoglycate 치료효과의 예측인자
강윤정(Yoon Jeong Kang),고형기(Hyoung Gee Koh),신종욱(Jong Wook Shin),임성룡(Seong Yong Lim),최재선(Jae Sun Choi),유지훈(Ji Hoon Yoo),김상훈(Sang Hoon Kim),박인원(In Won Park),최병휘(Byoung Whu Choi),허성호(Sung Ho Hue) 대한내과학회 1997 대한내과학회지 Vol.52 No.1
N/A Objectives: Although DSCG protects against the stimuli of various bronchoconstictor, such as exercise, it is not effective to all patients. There seems to be no therapeutic predictor that determines effectiveness of DSCG on bronchial asthma. Although it is commonly assumed that children with predominantly allergic asthma have a better response to DSCG therapy than adult patient, this has not been convincingly demonstrated, and even adult with late onset nonallergic asthma may benefit. In this study, we evaluated the factors that potentially influenced the ability of DSCG to reduce bronchial hyperresponsibility. Methods: The treatment groups were sub-divide into effective group(n=14) and ineffective group(n=6) on the basis of significant improvement of followedup PC20 after long term therapy of DSCG. We compared clinical and laboratory data and pulmonary function test between two groups. Resutls: 1) Disease durtion and pre-treatment pulmonary function (FEV1% predicted, FVC% predicted value) may play a role in determining effectiveness of DSCG on bronchial asthma(p<0.05). 2) Allergic rhinitis history seems to have been associated with effectiveness of DSCG(p<0,05). But this findings was not clearly demonstrated the association of atopic status because skin test, eosinophil count, serum IgE level were not significant difference between two groups(p>0.05). Conclusion: These results show that DSCG is effective in adult chronic asthma and early administration of DSCG, good pulmonary function test and allergic rhinitis history may lead to more favorable outcome.