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RISS 인기검색어
- 검색키워드
- 저자 : 한성욱 ( Sang Jik Lee (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Malachite Green 유도체의 합성과 항균성에 관한 연구
이상직,김종대,최재환,한성욱,Lee, Sang-Jik,Kim, Jong-Dae,Choi, Jae-Hwan,Han, Sung-Wook 생화학분자생물학회 1991 한국생화학회지 Vol.24 No.4
Malachite green derivatives bearing methyl, methoxy, hydroxyl and amino group were synthesized by the condensation reaction of N,N-dimethylanilin with substituted benzaldehydes. The yield of malachite green derivatives increased with addition of urea as an additive. Antimicrobial and antifungal activities of those compounds were evaluated in terms of minimum inhibitory concentration by the dilution method. It was observed that the antimicrobial and antifungal activity of the malacite green derivatives bearing electron-releasing substituents was stronger than that of the unsubstituted malachite green. From this result, it was concluded that the antimicrobial and antifungal activity of malachite green derivatives has a direct relationship with the electronic effect of the substituents. Malachite green에 $CH_3-$, $CH_3O-$, HO-, $NH_2-$ 기 등이 도입된 유도체를 합성하고, 이들의 항균성을 그람 음성균과 그람 양성균을 각각 2종, 진균 1종에 대하여 조사하였다. 즉, 이 유도체들은 진균에 대해 가장 강한 항균성을 나타내었고, 그람 음성균보다 그람 양성균에 대해 보다 강한 항균성을 보였다. 또한, malachite green 유도체의 치환기가 항균력에 영향을 주는 현상을 보였다. 즉, 전자를 밀어 주는 기일수록 더 센 항균력을 나타내었다. 이 결과로부터 malachite green 유도체에서 치환기의 전자효과와 항균성 사이에는 직접적인 연관성이 있음이 추측된다.
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Malachite Green 유도체의 합성과 항균성에 관한 연구
이상직,김종대,최재환,한성욱 ( Sang Jik Lee,Jong Dae Kim,Jae Hwan Choi,Sung Wook Han ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.4
Malachite green derivatives bearing methyl, methoxy, hydroxyl and amino group were synthesized by the condensation reaction of N,N-dimethylanilin with substituted benzaldehydes. The yield of malachite green derivatives increased with addition of urea as an additive. Antimicrobial and antifungal activities of those compounds were evaluated in terms of minimum inhibitory concentration by the dilution method. It was observed that the antimicrobial and antifungal activity of the malacite green derivatives bearing electron-releasing substituents was stronger than that of the unsubstituted malachite green. From this result, it was concluded that the antimicrobial and antifungal activity of malachite green derivatives has a direct relationship with the electronic effect of the substituents.
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Phenazine Ring을 가진 界面活性劑의 合成과 그 抗菌性 (제2보)
김종대,김동수,이상직,한성욱,Jong Dae Kim,Dong Soo Kim,Sang Jik Lee,Sung Wook Han 대한화학회 1983 대한화학회지 Vol.27 No.6
-Alkyl-2-hydroxyphenazine-5,10-dioxides were synthesized from hydroquinone, and alkyl benzofuroxanes which were previously obtained through five reaction steps starting from aniline. Infrared, nuclear mangnetic resonance spectrometry and elemental analysis were employed to identify the products concerned in the synthetic processes. It was observed that these alkylated phenazine oxides lowered the surface tension of water substantially. These derivatives showed stronger antimicrobial activity against both gram positive and negative microbes than 1-carboxyphenazine which had no alkyl side chain. It was also found that the antimicrobial activity of the phenazine compound increased when the nitrogen of the ring was bound to the oxygen atom. Aniline으로부터 출발하여 5단계를 거쳐 alkyo benzofuroxane을 얻고 이것과 hydroquinon과 반응시켜 7-Alkyl-2-hydroxyphenazine-5,10-dioxide을 合成하였다. 生成物은 IR, NMR spectrum, 元素分析 등으로 확인하였다. 이들 誘導體들의 수용액에 대한 表面張力을 測定하였고, 아울러 Gram 양성균과 Gram 음성균에 대한 抗菌性을 調査하였더니 alkyl기가 치환된 phenazine 유도체의 alkyl기가 없는 1-cahboxyphenazine보다 향균성이 강하고, 또한 phenazine 분자의 질소 원자에 산소 원자가 결합된 화합물이 가장抗菌性 이 강한 것이 판명되었다.
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