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증례보고 : 경식도 심초음파로 흉부 하행대동맥에서 발견된 심방중격 폐쇄장치 (Amplatzer septal occluder)
최대기 ( Dae Kee Choi ),윤선경 ( Sun Kyung Yoon ),진지현 ( Ji Hyun Chin ),하승일 ( Seung Il Ha ),이은호 ( Eun Ho Lee ),최인철 ( In Choel Choi ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.4
Percutaneous device closure of atrial septal defect (ASD) has proven to be safe and effective, and become a widely accepted option to the surgical repair. However, the embolization of Amplatzer septal occluder (ASO) occurs in about 0.55% to 3.5% of cases, regardless of ASD size, device size, or the physician`s expertise. We report a case of embolization of an ASO into the thoracic descending aorta, successfully removed through a surgical approach. (Korean J Anesthesiol 2009;56:453~6)
토끼 두개골 결손창에 대한 골형성단백질을 함유한 골왁스 처치 효과에 관한 연구
최재구,하승일,김준범,Hollinger,Jeffrey O. 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.7
Bone is a storehouse of biologic factors enabling it to regenerative without scar formation. Recombinant technology has made many of these factors available in significant quality for therapeutic applications. However, a delivery system of recombinant bone regenerating factors is needed. Biodegradable, biocompatable polymers have made it possible for delivering bone regenerative factors, such as bone morphogenetic protein(BMP). The overall goal of this study was to assess an experimental biodegradable polymer with wax-like handling properties that was combined with recombinant simian transforming growth factor beta(rs TGF-β). The purpose of this study was to validate biodegradability, biocompatability, hemostasis and bone promotion within standard-sized defects. The experimental design included 24 skeletally mature New-Zealand white rabbit divided evenly between two time periods (6 and 12 weeks) and the experimental wound model was two standard-sized circular defects 8 mm in diameter on each side of rabbit calvaria. At necropsy, a rectangular-shape segment of the calvaria was removed that included the parietal bones and defect sites. The segment was radiographed and x-ray films were assessed for radiopacity by computer assisted imaging analysis technique(i.e, radiomorphometry). Following radiography, bone formation within the defects was quantified by a computer imaging technique(hismtorphometry). Radiopacity associated with the experimental bone wax polymers was significantly greater than that of the untreated controls. Quantitative histomorphometry revealed the amount of new bone within the untreated controls was significantly greater than the experimentally treated sites. As a result, bone-wax did not satisfy the condition of ideal carrier of BMP but had some advantage in clinical use. The follow-up study must be produced for improvement of the substitution of bone with BMP in carrier.