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황련해독탕(黃連解毒湯)과 및 가미방의 인지기능회복에 대한 연구
공민정,하니나,이하영,김용태,노승주,김호철 대한본초학회 2004 大韓本草學會誌 Vol.19 No.4
Objectives : The purpose of the study we report here was to determine recovery of spatial cognitive of HwangRyunHaeDok-Tang (Huang-lian-jie-du-tang, HT, 黃連解毒湯) and its modified prescription(HTM) on global ischemia induced by 4-vessel occlusion in wistar rats. Method : The sample of HT and HTM were prepared by lyophilization after extraction with 100% water. Rats were induced to 10 minutes of forebrain ischemia by 4-vessel occlusion (4-VO) and reperfused again. They were administered at a dose of 300mg/kg to 0 minutes and 90 minutes after 4-VO. Functional improvement was evaluated with the Morris water maze at 7 days after ischemia. Rats were sacrificed after behavior test and the number of CA1 pyramidal neurons were counted in hippocampal sections stained with cresyl violet. Result : Compared to control group, HT and HTM groups confirmed that contributes to behavioral improvement. The administration of HT and HTM showed a significant neuroprotective effect on hippocampal CA1 neurons after ischemia compared to cotrol group. Conclusion : The results of this study demonstrate that administration of HT and HTM is effective in reducing neuronal damage and functional recovery in response to transient forebrain ischemia.
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참당귀의 흰쥐 4-Vessel Occlusion 전뇌허혈에 대한 신경방어효과
김영옥,하니나,부영민,박선영,박주영,유영법,신준식,안덕균,김호철 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2
Objectives : Angelicae Radix, the root of Angelica gigas N_AKAI (Umbelliferae) , which has been used to nourish the blood(補血), regulate menstruation(調經), relieve pain and promote bowel movements(崩漏) and activate blood circulation for the treatment of fatigue, headache, constipation and blood troubles in traditional Korean medicine. It's flavour and channel tropism is sweet(甘), pungent(辛), warm(溫), acting on the lung, heart and spleen(肺, 心, 脾). The purpose of study we report here was to determine the neuroprotective effect of Angelica gigas on global ischemia induced by 4-vessel occlusion in Wistar rats. Methods : Angelica gigas extracts was lyphilized after extraction with 85% methanol. We induced 4-VO for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. Results : The results showed that Angelica gigas had significantly neuroprotective effects (100, 250 and 500mg/kg of AR extracts, p<0.001) compared with control group. Each neuroprotective ratio was about 66.1, 79.3 and 78.6% respectively. Immunohistochemical data partially explained the protective effects of Angelica gigas via attenuation of COX-2 induction in hippocampus. Conclusion : Angelica gigas gas neuroprotective effects on the global ischemia induced by 4-vessel occlusion in Wistar rats and the attenuation of COX-2 induction is thought to be its possible mechanism.
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