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천성용(Sung Yong Chun),최영옥(Young Wook Choi),박동수(Dong Soo Park) 한국체육교육학회 2013 한국체육교육학회지 Vol.18 No.1
본 연구는 규칙적인 태권도 수련이 일반 대학생들에 있어서 신체조성과 기초체력에 미치는 영향을 알아보기 위해 J지역 S대학에 재학 중인 대학생들 대상으로 평소 운동 경험이 없는 대학생(대조군 10명)과 지속적으로 태권도 수련을 하고 있는 대학생(실험군 10명), 총 20명을 선정하여 실시하였다. 통계는 집단 간 차이를 알아보기 위해 PASW Statistics 18.0 통계프로그램을 이용하여 각 변인별 평균값과 표준편차를 구하였으며, 집단 간 차이검증은 t-검정을 실시하였다 이때 모든 유의 수준은 p<.05로 설정하였다. 연구 결과 신체조성에서 제지방량이 태권도 수련집단에서 유의하게 높게 나타났으며(p<.05), 기초체력 검사에서는 유연성, 서전트 점프, 전신반응과 윗몸일으키기에서 태권도 수련 집단이 유의하게 높은 것으로 나타났다(p<.01). 등속성 신전근력 검사에서는 각속도 180°/sec(p<.05), 굴곡근력 검사에서는 각속도 60°/sec (p<.05)와 각속도 180°/sec(p<.01)에서 태권도 수련 집단이 유의하게 높게 나타났다. 등속성 신전/굴곡 최대근력비에서는 각속도 60°/sec 왼발에서만 유의하게 높게 나타났다(p<.05). 따라서 이 연구 결과 지속적인 태권도 수련은 근육량의 증가와 기초체력 능력을 향상시키는데 효과적인 것으로 사료되며, 하지 근육의 안정성과 운동 능력을 향상시키기 위해 무릎 굴곡근의 발달이 높은 것으로 사료된다. This research explored the impact of Taekwondo training on the body composition and basic physical strength of university students. To proceed this study, one comparison group for not exercising usually and the other experiment group for training Taekwondo continuously were employed from ``S`` university in ``J`` area. To see the group difference, mean score and standard deviation were calculated and then t-test was executed by using PASW Statistics 18.0 program. All significance level was set as(p<.05). The results revealed that the training group significantly showed higher score(p<.05) at overall fat amount. At the test of basic physical strength, the Taekwondo training group also scored more at flexibility, sergeant jump, whole body reaction, and sit-up(p<.01). The Taekwondo training group scored significantly higher at angular velocity 180°/sec(p<.05) condition of isokinetic extension muscle strength test and also at angular velocity 60°/sec(p<.05) and 180°/sec(p<.01) condition of bend muscle strength. At the test of isokinetic extension/bend maximum muscle strength, only the conditon of angular velocity60°/sec left foot showed significantly higher score(p<.05). Therefore, the research results proved that continuous Taekwondo training would be effective to increase muscle mass and to improve basic physical strength capicity. Furthermore, the training group`s knee flexural muscle could develop more in stabilizing lower limb muscle and in improving exercise capacity.
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카르보폴 - 젤라틴의 상분리법을 이용한 Acyclovir 마이크로캅셀 현탁액의 제조 및 생물학적 평가
한양희,조진호,이정우,최영옥 한국약제학회 1993 Journal of Pharmaceutical Investigation Vol.23 No.3
Microencapsulation of acyclovir, an effective antiviral agent which acts as a specific inhibitor of herpes DNA polymerase, by carbopol-gelatin complex coacervation has been carried out to develop an oral controlled release preparation, which could improve the absorption characteristics in GI tract. After dissolving carbopol and gelatin separately in distilled water at 40℃, gelatin solution was mixed with carbopol solution while stirring at the same temperature. The pH of the mixture was lowered gradually by dropwise addition of 10% HCl with continuous stirring, and then, at pH 3.5, positively charged gelatin molecules were attracted to negatively charged carbopol. These coacervation processes were observed by optical microscopy during preparation. Plasma concentrations of acyclovir in rats after an oral administration of microcapsule suspension were assayed by HPLC, and pharmacokinetic parameters were calculated based on the model-independent analyses. Two standard formulations, oral solution and intravenous bolus injection, were used as references to compare the bioavailability. It has been revealed that C_(max), t_(max), and MRT of microcapsule suspension were greater than those of oral solution, which results in about two-fold increases in bioavailability. Therefore, in conclusion, the carbopol-gelatin microcapsule of acyclovir might be evaluated as an effective oral controlled release preparation which could increase the bioavailability of acyclovir.
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