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Barbiturate 정주, 초저체온 및 순환 정지를 이용한 거대 뇌동맥류 수술의 마취 1예
윤대영,정순호,최영군,김영재,박진우,신치만,박주열 인제대학교 1997 仁濟醫學 Vol.18 No.1
영구적인 뇌손상의 위험 때문에 일반적으로 거대 뇌 동맥류는 외과적 처치를 피해왔었다. 그러나 마취 및 체외순환이 개선되고 발전하여 순환 정지를 이용한 방법이 거대 뇌 동맥류의 결찰의 부작용을 감소시켰다. 본 병원에서 뇌 보호 및 안전한 수술을 위해 barbiturate를 병용한 마취와 체외 순환을 이용하여 중심 체온을 18℃까지 하강시킨 저체온하에서 순환 정지 동안에 시행한 거대 뇌동맥류 결찰의 마취 1예를 경험하였기에 보고하는 바이다. Because of the various risks of permanent neurological injury, neurosurgeons generally hale avoided any attempts at surgical ablation of giant cerebral aneurysms. But techniques of special anesthesia and cardiopulmonary bypass have been developed to make this operative procedure safe during temporary circulatory arrest. We report 1 case of anesthesia using special anesthetic with barbiturate and deep hypothermia to 18℃ that protect the brain during temporary cardiac arrest for surgical ablation of giant cerebral aneurysm.
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대황산(大黃酸)의 당뇨병쥐 신장조직섬유화 억제 효과에 관한 실험연구
조용걸,조정림,장걸,류홍봉,최영군,김상찬,김선형,Zhao, Rongjie,Zhao, Zhenglin,Zhang, Jie,Liu, Hongfeng,Cui, Rongjun,Kim, Sang Chan,Kim, Sun-Hyung 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.1
Objectives : To investigate the therapeutic effect and underlying mechanisms of rhein on renal fibrosis in diabetic rats. Methods : Diabetic nephropathy (DN) was induced in adult Wistar rats via introperitoneal injection of streptozotocin (STZ) (20 mg/kg/d) for three consecutive days. Two days after the last dose of STZ, rhein was administered to the diabetic rats at a dose of 25 mg/kg or 50 mg/kg, twice a day by gavage, respectively. Following 28 days treatment with rhein, the plasma glucose and creatinine levels were measured, the renal levels of TGF-${\beta}1$ protein and mRNA were examined, and the fibronectin mRNA levels were also determined. Results : Rhein significantly inhibited the increased plasma glucose and creatinine levels of diabetic rats in a dose- and a time-dependent way. Immunohistochemical analysis showed both doses of rhein markedly attenuated elevated induction of renal TGF-${\beta}1$ protein expressions in diabetic rats. Additionally, the high dose of rhein improved both TGF-${\beta}1$ and fibronectin mRNA expressions, while the low dose of rhein only alleviated fibronectin mRNA expressions. Conclusions : Rhein can improve renal fibrosis in diabetic nephropathy rats, and which may be mediated through inhibition of the renal mRNA expressions of TGF-${\beta}1$ and fibronectin.
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