척출 냉혈동물 심방의 Alpha-Adrenoceptors에 관한 연구(I) 개구리 심방의 clonidine, oxymetazoline 및 phenylephrine에 대한 반응

최수형(Soo Hyung Choi),박행순(Haeng Soon Park),신동호(Dong Ho Shin) 대한약학회 1988 약학회지 Vol.32 No.2

Effects of the selective alpha-adrenoceptor agonists, clonidine, oxymetazoline and phenylephrine, on heart rate and contractile force were investigated in the isolated frog atria and it was attempted to examine the influence of adrenoceptor antagonist upon those. Clonidine produced dose-dependent negative chronotropic and positive inotropic effects. The negative chronotropic effect was significantly attenuated in the presence of prazosin and yohimbine but not propranolol. The positive inotropic effect was significantly attenuated by prazosin, yohimbine and propranolol. Oxymetazoline produced dose-dependent negative chronotropic and inotropic effects. The negative chronotropic effect was significantly attenuated in the presence of prazosin, which was partially augmented by yohimbine but was not affected by propranolol. The negative inotropic effect was not affected by propranolol but it was partially augmented by yohimbine and was partially attenuated by prazosin. Phenylephrine produced dose-dependent positive chronotropic and inotropic effects. The positive chronotropic and inotropic effect were significantly attenuated in the presence of propranolol but were not affected by prazosin and yohimbine. These results suggest that the negative chronotropic effect by clonidine and oxymetazoline is mediated by alpha-adrenoceptors, the positive chronotropic and inotropic effects by phenylephrine are mediated by beta-adrenoceptors, and alpha-adrenoceptors mediated the inhibitory chronotropic responses exists in the isolated frog atria.

소각 중성자 산란(SANS)을 이용한 블록 공중합체 마이셀의 동역학 연구

최수형(Soo Hyung Choi) 한국고분자학회 2013 고분자 과학과 기술 Vol.24 No.6

수종 생약의 48시간 동종 수동 피부 아나필락시와 화학적 전달물질에 대한 작용

최수형(Soo Hyung Choi),배은옥(Eun Ok Bae),임동구(Dong Koo Lim),김영란(Young Ran Kim) 대한약학회 1992 약학회지 Vol.36 No.4

Actions for 48-hour homolgous passive cutaneous anaphylaxis (48-hr PCA) and chemical mediators were investgiated in mice and rats. The hyaluronidase activity, which was used in the in vitro screening test of the antiallergic action, was significantly inhibited by Magnoiliae Flos, Achyranthis Radix, Forsythiae Fructus, Alpiniae Fructus, Anemarrhenae Rhizoma and Ponciri Fructus among twelve medicinal plants and tranilast as a comparative drug of the antiallergic action. In the mouse ear, 48-hr PCA was significnatly inhibited by intraperitoneal (i.p.) pretreatment with Magnoliae Flos, Achyranthis Radix, Alpiniae Fructus, Anemarrhenae Rhizoma, Ponciri Fructus, Ledebouriellae Radix and tranilast. And also, the increment of vascular permeability induced by histamine or serotonin was inhibited significantly by i.p. pretreatment with Magnoliae Flos, Achyranthis Radix, Alpiniae Fructus, Anemarrheuae Rhizoma, Zizyphi Fructus and tranilast. In the rat dorsal skin, the increment of vascular permeability induced by histamine or serotonin was significantly inhibited by i.p. pretreatment with Magnoliae Flos, Acyranthis Radix, Alpiniae Fructus, Anemarrhenae Rhizoma and tranilast. And also, the increment of vascular permeability induced by compound 48/80 or calcium ionophore A 23187 was significantly inhibited by i.p. pretreatment with Magnoliae Flos, Achyranthis Radix, Alpiniae Fructus, Amemarrhenae Rhizoma, Zizyphi Fructus, Ledebouriellae Radix, Lithospermi Radix and tranilast. These results suggest that each water extracts of Magnoliae Flos, Achyranthis Radix, Alpiniae Fructus and Anemarrhenae Rhizoma have especially antiallergic activities.

Scaling Relationship of Complex Coacervate Core Micelles

Soo-Hyung Choi(최수형),허태영,Debra J. Audus 한국고분자학회 2023 한국고분자학회 학술대회 연구논문 초록집 Vol.48 No.2

Relaxation Mechanism of Complex Coacervate Core Hydrogels: Chain Length Asymmetry

Soo-Hyung Choi(최수형) 한국고분자학회 2023 한국고분자학회 학술대회 연구논문 초록집 Vol.48 No.1

수종 생약의 항알레르기 작용

최수형(Soo Hyung Choi),김영란(Young Ran Kim),임동구(Dong gu Lim),배은옥(Eun Ok Bai) 대한약학회 1992 약학회지 Vol.36 No.2

Anti-allergic action of each water extracts of some crude drugs was investigated in mice and rats. The activity of hyaluronidase which was used in the screening test of anti-allergic action was inhibited significantly by Amomi Semen, Asiasari Radix, Cimicifugae Rhizoma, Cinnamomi Ramulus, Glycyrrhizae Radix and Scutellariae Radix. The 48-hour homologous passive cutaneous anaphylaxis(48-hr PCA) in mouse ear was inhibited significantly by intraperitoneal(i.p.)injection of Amomi Semen, Cimicifugae Rhizoma, and ketotifen, a comparative drug of an anti-allergic action. The increase of vascular permeability induced by histamine or serotonin was inhibited significantly by i.p. injection of Ammi Semen, Cimicifugae Rhizoma, Cinnamomi Ramulus and ketotifen. In rat dorsal skin, the increase of vascular permeability which was induced by histamine, serotonin or compound 48/80 was inhibited significantly by i.p. inhibit 48-hr PCA and the increase of histamine, serotonin or compound 48/80-induced vascular permeability in mice and the increase of histamine, serotonin or compound 48/80-induced vascular permeability in mice and rats. Theses results suggest that each water extract of Amomi Semen and Cimicifugae Rhizoma has anti-allergic action.

X-ray/중성자와 연성 소재

최수형(Soo Hyung Choi) 한국고분자학회 2013 고분자 과학과 기술 Vol.24 No.6

Effects of Subacute Administration of Physostigmine on Dopamine Metabolism in Rat Striatum

임동구,최수형,Lim, Dong-Koo,Choi, Soo-Hyung The Korean Society of Pharmacology 1992 대한약리학잡지 Vol.28 No.1

Physostigmine을 급성(0.75 mg/kg), 7일간 매일 1회(0.75 mg/kg) 그리고 7일간 연속(0.15 mg/kg/h) 투여한 쥐의 선조체에 있어서 dopamine(DA) 및 대사체와 tyrosine hydroxylase(TH)활성도의 변화를 검색하였다. 급성 투여 1시간 후 선조체의 DA 농도는 변화가 없었으나 dihydroxy-phenylacetic acid(DOPAC)과 homovanillic acid(HVA)농도는 증가하였다. 또한 DA의 turnover의 증가를 제시하는 DOPAC/DA와 HVA/DA의 비율도 증가하였다. 그러나 TH활성도는 24시간 후 감소를 나타내었다. Physostigmine을 매일 및 연속 투여군에서는 DA과 대사체의 농도에는 변화가 없었으나, DA의 turnover의 감소를 제시하는 DA과 대사체의 비율은 감소하였다. 그러나 TH활성도는 매일 투여군에서만 감소를 나타내었다. 이러한 결과는 physostigmine을 급성 및 아급성으로 투여시 dopamine대사의 변화가 있음을 제시한다. 또한 콜린 신경계의 아급성 자극은 dopamine 대사 및 활성도를 감소 시킬 가능성을 시사해 주었다. Rats were treated with physostigmine, using 0.75 mg/kg acutely, with 0.75 mg/kg daily for 7 dats, or with 0.15 mg/kg/h continuously for 7 days. Striatal dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels and tyrosine hydroxylase (TH) activities were studied. After acute treatment striatal DOPAC and HVA concentrations were significantly increased without changes in DA level 1 h, but not 24 h. And also the ratios of DOPAC/DA and HVA/DA were increased, suggesting an increased turnover of DA. however TH activities were decreased 24h, but not 1h after acute administration. After both daily and continuous treatment with physostigmine for 7 days, neither DA nor its metabolites were changed. However their ratios were decreased, suggesting a decreased turnover of DA. The TH activities were only decreased in the daily treated group, but not in the continously treated one. These results indicate that dopamine metabolisms are changed after acute and subacute administration with physostigmine. Further it suggest that the subacute stimulation of cholinergic activity may induce the dopamine metablism and activity to be decreased.

Oxymetazoline의 가토장편운동(家兎腸片運動) 억제작용(抑制作用) 등장성(等張性) 및 등장성(等張性) 기록방법(記錄方法)의 비교(比較)

신동호,최수형,Shin, Dong-ho,Choi, Soo-hyung 대한수의학회 1985 大韓獸醫學會誌 Vol.25 No.1

The inhibitory action of oxymetazoline on the spontaneous movements of isolated intestinal strips of the rabbit and the effects of antagonists upon the oxymetazoline actions were assessed with recordings through both isometric and isotonic transducers, and comparisons were made between both methods of recording. There were significant differences between the slopes of regression equations calculated from log dose response curves of oxymetazoline obtained from jejunum and those from ileum. But no difference was noted between both recordings either through isotonic transducer or through isometric transducer. The $ID_{50}$ of oxymetazoline obtained from the recording through isotonic transducer was $6.31{\times}10^{-7}M$ in jejunum and $3.16{\times}10^{-8}M$ in ileum. The recording through isometric transducer gave the values of $5.01{\times}10^{-7}M$ in jejunum and $1.07{\times}10^{-8}M$ in ileum. The $pA_2$-values of prazosin to oxymetazoline calculated from the recording through isotonic transducer were 8.13 in jejunum and 8.31 in ileum and the recording through isometric transducer gave the values of 7.29 and 8.26 in jejunum and ileum, respectively. The $pA_2$-values of phentolamine to oxymetazoline obtained from the recording through isotonic transducer were 8.18 in Jejunum and 9.31 in ileum and those from the recording through isometric transducer were 7.75 and 8.13 in jejunum and ileum, respectively. These results indicate that there are no significant differences between recordings either through isotonic transducer or through isometric transducer in assessing inhibitory responses of intestinal movement to certain drugs.

${\alpha}_1-Adrenoceptor$ Agonist로서의 Oxymetazoline -가토혈압(家兎血壓) 상승작용(上昇作用)-

박영태,최수형,Park, Young-Tae,Choi, Soo-Hyung 대한약리학회 1982 대한약리학잡지 Vol.18 No.2

1) 여러가지 말초(末梢) 조직(組織)에서 ${\alpha}_1-adrenoceptor$의 agonist로 알려져 있는 oxymetazoline의 측뇌실내(側腦室內) 투여(投與)는 urethane마취가토(麻醉家兎)의 혈압상승(血壓上昇)을 일으켰다. 이 상승(上昇)은 guanethidine, chlorisondamine처리(處理)로 거의 영향(影響)을 받지 않았고, phenotolamine, guanethidine과 chlorisondamine 또는 부신결찰(副腎結紮)과 guanethidine처리하(處理下)에서는 억제(抑制)되었다. 2) 측뇌실내(側腦室內) oxymetazoline에 의한 혈압상승(血壓上昇)은 측뇌실내(側腦室內) prazosin투여후(投與後)에는 현저(顯著)히 감약(減弱)되었으나 yohimbine 및 piperoxan의 영향(影響)은 받지 않았다. 3) Reserpine처리(處理) 가토(家兎)에서도 측(側) 뇌실내(腦室內) oxymetazoline은 혈압(血壓) 상승(上昇)을 일으켰으며, 이도 측(側) 뇌실내(腦室內) prazosin투여후(投與後)에는 현저(顯著)히 감약(減弱)되었으나 yohimbine의 영향(影響)은 받지 않았다. 4) 전신마취(全身麻醉) 가토(家兎) 및 척수가토(脊髓家兎)에서 정맥내(靜脈內) oxymetazoline은 혈압상승(血壓上昇)을 일으켰으며 이 상승효과(上昇效果)에 대(對)한 정맥내(靜脈內) ${\alpha}_1-adrenoceptor$ antagonist의 길항능력(拮抗能力)은 prazosin, phentolamine, yohimbine의 순(順)으로 강(强)하였다. 5) 본(本) 실험성적(實驗成績)은 oxymetazoline이 혈압조절(血壓調節)에 관여(關與)하는 가토(家兎) 뇌조직(腦組織) 및 가토(家兎) 혈관근(血管筋)에서는 ${\alpha}_1-adrenoceptor$ agonist로 작용(作用)함을 가리키고 있다. 1) Oxymetazoline, which has been known as an agonist for${\alpha}_1-adrenoceptor$ in various peripheral tissues, caused a pressor response in urethane-anesthetized rabbits when given intra-ventricularly. This pressor response was little affected by pretreatment of rabbits with i.v. guanethidine or chlorisondamine, but it was weakened in rabbits pretreated with either of i.v. phentolamine or guanethidine and chlorisondamine and in guanethidine-pretreated adrenal-ligated rabbits. 2) The pressor to intraventricular oxymetazoline was markedly attenuated by intraventricular pretreatment with prazosin, whereas intraventricular pretreatment with yohimbine or piperoxan did not affect this response. 3) Reserpine-pretreated rabbits also responded with hypertension to intraventricular oxymetazoline, which was markedly diminished by pretreatment with intraventricular prazosin but not affected by yohimbine. 4) Oxymetazoline, given intravenously, produced a pressor response in both whole and spinal rabbits. Intravenous prazosin, phentolamine and yohimbine, in this order, showed greater antagonizing effect to this pressor response. 5) The results indicate that oxymetazoline acts an agonist for ${\alpha}_1-adrenoceptors$ in the rabbit brain participating in the regulation of the blood pressure and in the vasculature of rabbits.