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동물매개활동(AAA)이 경도인지장애를 가지고 있는 노인의 인지기능과 우울증에 미치는 영향 -단일 피험자 실험설계-
최상열 ( Sang Yul Choi ),성치호 ( Chi Ho Seong ),홍은지 ( Eun Ji Hong ),한상우 ( Sang Woo Han ) 고령자·치매작업치료학회 2014 고령자.치매작업치료학회지 Vol.8 No.2
목적 : 경도인지장애로 의심되는 노인을 대상으로 동물매개활동 프로그램이 치료적 방법으로써 인지기능과 우울감에 미치는 영향을 알아보고자 하였다. 연구방법 : 2013년 1월부터 3월까지 경도인지장애가 의심되는 65세 이상의 노인 3명을 대상으로, 총 15회기에 걸쳐 단일 피험자 실험설계(single subject design) A-B-A를 이용하여 진행하였다. 인지기능은 동물 매개활동 전·후에 신경심리평가집(CERAD-K)로 측정하여 인지변화에 대해 알아보았고, 우울증은 매회기 자가 우울측정 척도(SDS)를 이용하여 평가하였다. 연구결과 : 동물매개활동을 통하여 중재기간동안 지속적으로 우울증 감소가 유지되는 결과를 나타냈다. 인지기능에서도 단어기억항목이 공통적으로 점수가 향상되었으며, 언어유창성과 단어재인항목은 공통적으로 점수가 유지되었다. 결론 : 동물매개활동은 경도인지장애 노인들의 우울증을 감소시키고, 단어기억항목에서 공통적으로 증진된 효과를 나타냈다. 반대로 공통적으로 낮아지는 인지기능항목은 없었으며, 언어유창성과 단어재인 항목에서 공통으로 유지되었다. 향후에도 치매를 예방하고, 삶의 질을 높일 수 있는 동물매개활동에 관한 많은 연구가 이루어져야 할 것이다. Objectives : This study was aimed at the effects of Animal-assisted activities(AAA) on cognitive function and depression outcomes of elderly with mild cognitive impairment. Methods : A single-subject A-B-A’ experimental design was used to determine the effects of AAA. The intervention involved 30 minute sessions 3days/week for 5 weeks. Depression outcomes was collected through Self-rating Depression Scale respectively session. Consortium to Establish a Registry for Alzheimer’s Disease-Korean version was used to cognitive function before and after the intervention phase. Results : The results showed that AAA effectively reduced depression on the intervention phase. Word list memory was improved in all trial participants. Common in Word Fluency and Word list recognition did not changes. Conclusion : This study suggests that AAA could be a valuable method for reducing depression and improving working memory in elderly with MCI, possibly delaying the onset of Alzheimer’s disease.
박새미,최상열,최경식.Saemi Park. MD. Sang Yul Choi. MD. Kyung Seek Choi. MD. PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.6
Purpose: To report a rare case of choroidal metastasis from renal cell carcinoma. Case summary: A 61-year-old man visited our clinic with the chief complaint of decreased vision in the right eye. Three years earlier, he underwent right nephrectomy due to renal cell carcinoma. Best corrected visual acuity was 0.2 in the right eye and 1.0 in the left eye. Fundoscopic examination of the right eye revealed a yellowish, dome-shaped elevated choroidal mass with serous retinal detachment, measuring 5.0 × 4.0 disc diameter and located lateral to the macular area. Systemic evaluations showed multiple lung and brain metastases. A diagnosis of choroidal metastasis from renal cell carcinoma was made for the right eye, and the patient received local treatments with oral sorafenib therapy, composed of subtenon triamcinolone injection and intravitreal ranibizumab injection. Tumor progression continued, and visual acuity declined to hand motion. Enucleation was recommended, but the patient refused and is on a regular follow-up after transpupillary thermotherapy. Conclusions: Ocular manifestation may be the initial presenting sign of a recurrent tumor, and an extensive systemic evaluation for metastatic malignancy should be performed. The present example showed a rare case of choroidal metastasis from renal cell carcinoma. J Korean Ophthalmol Soc 2012;53(6):880-885
금속 이물질에 의한 육아종으로 의심되는 전방내의 색소성 종괴
박민선(Min Seon Park),최상열(Sang Yul Choi),이상목(Sang-Mok Lee) 대한안과학회 2017 대한안과학회지 Vol.58 No.2
목적: 금속 이물질에 의한 육아종으로 의심되는 전방내 색소성 종괴 1예를 경험하였기에 문헌 고찰과 함께 보고하고자 한다. 증례요약: 63세 남자 환자가 수년 전부터 발생한 우안 흐려보임을 주소로 내원하였다. 우안 상비측 각공막 경계부위 지름 2 mm 정도의 동심원상의 갈색침착과 함께, 전방내 일부 흰색 부분이 섞여 있는 균질한 갈색 직육면체모양(2 x 0.6 x 0.3 mm)의, 표면이 매끄럽고, 혈관이 없는 상비측의 종괴가 전방각경을 통해 관찰되었다. 종괴가 홍채를 약간 누르고 있어 동공은 상비측 쪽으로 끌리는 타원형 모양이었다. 전안부빛간섭단층촬영상 전부 각막기질과 내피세포층을 포함하는 후부 각막기질에 두 층의 분리된 고음영이 관찰되었다. 전산화단층촬영상 조영증강전검사에서 오른쪽 눈 전안부의 상비측에 지름 약 3.0 mm 크기의 대칭적인 원형의 높은 밀도의 고음영이 관찰되었다. 공막층판절개를 통한 절제생검을 고려하였으나, 환자의 좌안 시력이 좋지 않아 우안에 의존한 상태였으며, 여러 가지임상적 소견이 홍채흑색종보다는 육아종으로 판단되어 조직검사를 시행하지 않았다. 19개월의 경과관찰 기간 동안 종괴의 크기, 동공모양 등의 변화는 관찰되지 않았다. 결론: 전방내 색소성 종괴가 발견되면 홍채의 양성, 악성 종양 및 육아종 등의 감별진단이 필요한데, 안내종양의 경우 조직학적 진단을 얻기 어려운 경우가 있으므로 환자의 정확한 병력과 악성과 양성 종양을 구별한 수 있는 형태학적인 특성을 염두에 두고 진단에 활용하는 것이 중요하다. Purpose: To report on a patient with a brown pigmented mass in the anterior chamber suspected of a granuloma caused by a metallic foreign body and to review the relevant literature. Case summary: A 63-year-old man presented with blurring in his right eye, which had initially began several years prior. Concentric corneoscleral brown pigmentation about 2 mm in diameter was found in the superonasal limbal area. A rectangular parallelepiped mass was observed in the superonasal anterior chamber, which was an even brown color with a small white portion, smooth-surfaced, and non-vascularized. The pupil was oval and dragged superonasally, possibly due to mild compression of the iris caused by the mass. In pre-enhanced orbital computed tomography, a round high signal intensity with a diameter of 3.0 mm was found in the superonasal anterior segment. Though excisional biopsy using the lamellar scleral flap was considered for exact diagnosis, this was not performed considering the clinical features are more indicative of granuloma than iris melanoma. Neither changes in the size of the mass nor the shape of the pupil were observed during the follow up period until 19 months after the first visit. Conclusions: When a pigmented mass in the anterior chamber is detected, benign and malignant iris tumors and granulomas should be considered for a differential diagnosis. The patient’s exact past medical history and clinical features differentiating malignant and benign masses are important for proper diagnosis due to the difficulty in obtaining tissue diagnoses in some cases.
돼지에 있어 원적외선 방사물질의 첨가가 면역반응 및 분중 미생물의 변화에 미치는 영향
권기범,김인호,홍종욱,문태현,최상열,석호봉,Kwon, Ki-bum,Kim, In-ho,Hong, Jong-wook,Moon, Tea-hyun,Choi, Sang-yul,Seok, Ho-bong 대한수의학회 2001 大韓獸醫學會誌 Vol.41 No.1
This research was conducted to investigate the effects of far infrared radiological materials on growth performance, immune response and changes of microbial flora in feces for growing pigs. Twelve growing pigs($Duroc{\times}Yorkshire{\times}Landrace$, average initial body weight of $15.6{\pm}0.5kg$) were used in a 40 day growth assay. Treatments were control(saline injection with diet: S); saline injection with Bio-Plus in diet(SBP); and vaccination with Bio-Plus in diet(VBP) in a randomized complete block design with initial BW as the blocking criterion. Serum concentrations of IgG of SBP and VBP were higher than those of S at day 10(p<0.05), 20(p<0.05), 30(p<0.05) and 40(p<0.05). Pigs fed with treatment diets had increased lymphocyte level compared to S at day 20(p<0.05) and 40(p<0.05). Cortisol was lower in treatments than in S at day 30(p<0.05). At day 20, there was no significant difference in E. coli among the treatments. However, it was observed that E, coli of the treatments was decreased compared to S at day 40(p<0.01). Lactobacillus of SBP was significantly higher(p<0.05) than that of S at day 40. In conclusion, the results of the experiment suggest that far infrared radiological materials could be a very beneficial immune response for growing pigs in health aspects.