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자궁경부 편평상피병변에서 자궁경부질도말 세포검사의 진단정확도 : 481예의 세포-조직 상관관계
진소영,박상모,김미선,진윤미,김동원,이동화,Jin, So-Young,Park, Sang-Mo,Kim, Mee-Sun,Jeen, Yoon-Mi,Kim, Dong-Won,Lee, Dong-Wha 대한세포병리학회 2008 대한세포병리학회지 Vol.19 No.2
Background : Cervicovaginal cytology is a screening test of uterine cervical cancer. The sensitivity of cervicovaginal cytology is less than 50%, but studies of cytologic/histologic correlation are limited. We analyzed the diagnostic accuracy of cervicovaginal cytology in the detection of the squamous epithelial lesions of the uterine cervix and investigate the cause of diagnostic discordance. Materials and Methods : We collected a total of 481 sets of cervicovaginal cytology and biopsies over 5 years. The cytologic diagnoses were categorized based on The Bethesda System and the histologic diagnoses were classified as negative, flat condyloma, cervical intraepithelial neoplasia (CIN) I, CIN II, CIN III, or squamous cell carcinoma. Cytohistologic discrepancies were reviewed. Results: The concordance rate between the cytological and the histological diagnosis was 79.0%. The sensitivity and specificity of cervicovaginal cytology were 80.6% and 92.6%, respectively. Its positive predictive value and negative predictive value were 93.7% and 77.7%, respectively. The false negative rate was 19.4%. Among 54 false negative cytology cases, they were confirmed by histology as 50 flat condylomas, 2 CIN I, 1 CIN III, and 1 squamous cell carcinoma. The causes of false negative cytology were sampling errors in 75.6% and interpretation errors in 24.4%. The false positive rate was 7.4%. Among 15 false positive cytology cases, they were confirmed by histology as 12 atypical squamous cells of undetermined significance (ASCUS) and 3 low grade squamous intraepithelial lesions (LSIL). The cause of error was interpretation error in all cases. The overall diagnostic accuracy of cervicovaginal cytology was 85.7%. Conclusions : Cervicovaginal cytology shows high overall diagnostic accuracy and is a useful primary screen of uterine cervical cancer.
백서에서 Dimethylnitrosamine에 의한 간경화의 유도와 간세포성장인자, 수용체인 c-Met, 그리고 형질전환인자-베타 1의 발현에 관한 연구
김욱환(Wook-Hwan Kim),이재호(Jae-Ho Lee),진윤미(Yoon-Mi Jin),조혜성(Hyeseong Cho),박혜리(Hye Lee Park),정민권(Min-Kwon Jung),곽연식(Yun-Sik Kwak),한상욱(Sang-Uk Han),왕희정(Hee-Jung Wang),이건욱(Kuhn-Uk Lee),김명욱(Myung-Wook Kim) 대한외과학회 1998 Annals of Surgical Treatment and Research Vol.55 No.4