Hyaluronic acid and proteoglycan link protein 1 suppresses platelet‑derived growth factor-BB-induced proliferation, migration, and phenotypic switching of vascular smooth muscle cells

주단,Hae Chan Ha,양구원,Ji Min Jang,박보경,Zhicheng Fu,In Chul Shin,김대경 생화학분자생물학회 2023 BMB Reports Vol.56 No.8

The development of atherosclerotic cardiovascular disease isassociated with the phenotypic switching of vascular smoothmuscle cells (SMCs) from a contractile to a synthetic state,leading to cell migration and proliferation. Platelet‑derivedgrowth factor‑BB (PDGF‑BB) modulates this de-differentiationby initiating a number of biological processes. In this study,we show that gene expression of hyaluronic acid (HA) andproteoglycan link protein 1 (HAPLN1) was upregulated duringdifferentiation of human aortic SMCs (HASMCs) into a contractilestate, but downregulated upon during PDGF-BB-induced dedifferentiation. This is the first study showing that the treatmentof HASMCs with full-length recombinant human HAPLN1(rhHAPLN1) significantly reversed PDGF-BB-induced decreasein the protein levels of contractile markers (SM22α, α-SMA,calponin, and SM-MHC), and inhibited the proliferation andmigration of HASMCs induced by PDGF-BB. Furthermore, ourresults show that rhHAPLN1 significantly inhibited thephosphorylation of FAK, AKT, STAT3, p38 MAPK and Rafmediated by the binding of PDGF-BB to PDGFRβ. Together,these results indicated that rhHAPLN1 can suppress thePDGF-BB-stimulated phenotypic switching and subsequentde-differentiation of HASMCs, highlighting its potential as anovel therapeutic target for atherosclerosis and other vasculardiseases.

1P-283 Mussel-inspired Coating of Polyhedral Oligomeric Silsesquioxane

주단비,박종엽,권빈희,정우준,인인식 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.0

P-82 : 중금속 존재 시 biogenic Mn 산화물 생성 특성 및 biogenic Mn 산화물의 중금속 흡착 특성

주단화 ( Dan Hua Zhou ),김도군 ( Do Gun Kim ),고석오 ( Seok Oh Ko ) 한국물환경학회(구 한국수질보전학회) 2013 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2013 No.-

Mussel-Inspired Hard Coating showing Antiscratching and Antibacterial Performance

주단비,인인식,조성호,채아리,최유진 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1

Mussel-inspired chemistry is unique chemistry of catechol-functionalized organic and nanomaterials and widely acceptable with the purpose of surface coating. In this study, highly silicated cluster molecule, POSS is catecholized through the sequential reactions. The resulting catecholderivatzied POSSs show high antiscratching and antibacterial performance. The chemistry and smart coating performance of catecholized POSS will be highlighted in detail. ^**2016년 한국교통대학교 지원을 받아 수행하였음.

Preparation of Water-soluble Silicon quantum dots through microwave reactor from monosaccharides

조성호,인인식,최유진,채아리,권빈희,정우준,박종엽,주단비,( Nur`aeni ) 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1

Recently, plenty intense research interests have been focused on the development of water-soluble fluorescence quantum dots. Many researches have reported that highly fluorescent and water-dispersible SiQDs using silicon source and organic capping agent. This silicon-based SiQDs are many applications including photo-catalysis, light-emitting displays, and even bio-imaging. Herein, we reported simply synthetic method via microwave reactor using monosaccharides and silicon resources in non-harsh condition. The resulting SiQDs show high luminescence and good-solubility in aqueous media together with extremely low cytotoxicity with extremely low cytotoxicity and environmental friendly. Further detailed characterization of monosaccharidebased SiQDs will be discussed in detail. ^**2016년 한국교통대학교 지원을 받아 수행하였음.

디자인과 수요가 융합된 중국 어린이 가구 소비 선호 및 디자인 트렌드 연구

주단(Zhou, Dan),이성원(Lee, Sung Won) 한국전시산업융합연구원 2020 한국과학예술융합학회 Vol.38 No.4

본 연구는 중국의 14세 이하의 어린이 인구는 약 2.3억여 명으로 전체 인구의 1/4를 차지하고 있으므로 중국 어린이 가구 시장의 잠재력이 매우 크다는 것에서 시작한다. 2015년에 중국의 알타이정책(二胎政策) 실행 이후 어린이 인구가 해마다 증가하면서 중국 어린이층의 수요가 갈수록 중요시되어 가고 있다. 따라서 어린이의 성장에 맞는 어린이 중심으로 한 가구디자인은 어린이 가구 디자인의 새로운 트렌드가 되었다. 본 연구의 목적은 중국 어린이 가구 구매 시 선택 선호 요인과 소비에 따른 수요를 분석하여 중국 내 어린이 가구 디자인 개발에 기초 자료로 참고할 수 있도록 가이드를 마련하는 것이다. 우선, 중국 어린이 가구의 소비 수요와 구매 행위를 분석하였고 둘째, 어린이 가구의 디자인 특징을 분석하고 정리하였다. 셋째, 중국 어린이 가구의 브랜드 현황 및 시장 규모, 그리고 미래 트렌드에 대한 분석을 통해 중국 어린이 가구 브랜드의 디자인 요소를 살펴보았다. 마지막으로 중국 어린이 가구 소비자 149명을 대상으로 구매 특성과 가구 구매 시의 선택 선호 요인을 조사하였다. 분석한 결과를 통해 재료 선택에서 소비자가 가장 중요시하는 것은 재질이고 원목 가구에 대한 선호도가 비교적 높다는 것을 확인할 수 있다. 또한, 가격에 있어서 소비자가 가장 받아들이기 쉬운 가격대는 중간급의 가격대이다. 사용 만족도의 경우 가구를 구매한 2년 안에 어린이 가구에 대한 만족도가 가장 높게 나타났고 디자인에서 어린이 가구의 오락성을 중요시하며 어린이에게 즐거움을 주는 스마트 어린이 가구를 더 선호하는 것으로 나타났다. Since there are more than 300 million children in China, accounting for a quarter of the country’s total population, the children furniture market of China has huge potential. After the introduction of the two-child policy in China in 2015, the number of children has been increasing year by year, and the needs of children in China have been gaining more attention. It is a new design trend to design the humanized furniture that meets the needs of children’s growth. This thesis aims to provide basic materials and advice for the design of China’s children furniture based on the consumption demand and choice preference of Chinese children. Firstly, analyze the consumption demand and purchasing behavior of China’s children furniture. Secondly, analyze and conclude the design features of children furniture. Thirdly, make an analysis of the current situation and future trend of China’s children furniture, and understand the design elements of Chinese brand children furniture. Finally, make a survey of 149 China’s children furniture consumers in terms of purchasing features and choice preference. Through the analysis of the survey data of consumers, the following findings are obtained: in terms of the material selection, consumers pay attention to the materials of children furniture, and have a high preference for solid wood furniture; in terms of the consumer price, they can accept the middle-priced children furniture; with regard to the product satisfaction, the satisfaction of children furniture is the highest within two years after the purchase; in terms of design style, they attach importance to the children innocence of children furniture, preferring the smart children furniture that can bring happiness to children.

소비자의 가구 구매의사에 대한 VR 가상현실 기술의 영향에 관한 연구 : 어린이방 가구를 중심으로

주단(Zhou, Dan),이성원(Lee, Sung Won) 한국디자인리서치학회 2020 한국디자인리서치 Vol.5 No.3

가상현실 기술(VR)은 끊임없이 발전하여 가구 산업의 마케팅과 상품 전시에 응용되고 있다. 본 연구에서는 가구 산업에서 마케팅 방식에 대한 VR 전시 기술의 영향에 대해 연구하는 동시에 소비자들의 구매의사에 대한 VR 기술의 촉진작용에 대해 연구하는 것을 목적으로 하였다. 본 논문은 SPSS 20.0 프로그램을 이용하여 어린이방 가구 소비자들을 대상으로 진행한 유효한 설문지 282부에 대해 위계적 회귀분석을 진행하였다. 그 결과 어린이 가구 판매에서 VR 가상현실 기술을 이용하여 몰입식 정경으로 전시하는 것은 소비자의 구매체험을 증강할 수 있고 소비자의 구매의사를 촉진할 수 있다는 것을 보여준다. 또한 VR 가상현실 기술의 인터랙션, 유용성, 생동성은 어린이방 가구 구매의사에 현저한 영향을 미치고 지각인지는 VR 가상현실과 구매의사 간에 매개작용을 일으킨다는 결론을 얻었다. 연구결과에 근거하여 가구 산업의 매장 전시에서 새로운 기술의 활용을 강화하는데 참고적 자료를 제공하고 VR 가상현실 기술을 이용하여 소비자의 구매의사를 제고하는데 데이터와 실행가능한 이론적 의거를 제공하길 바란다. Virtual Reality (VR) technology is becoming more and more mature and has been gradually applied to the marketing and product exhibition of the furniture industry. This thesis aims to understand the impact of VR exhibition technology on the marketing mode of furniture industry and to analyze the role of VR technology playing in promoting consumers’ purchase intention. By adopting the software SPSS20.0, this thesis conducts a hierarchical regression analysis on 282 valid questionnaires of children’s furniture consumers. The research results have shown as follows: The sales of children’s furniture can enhance consumers’ shopping experience by using VR technology to display an immersive scene, and can also promote consumers’ purchase intention. The interaction, usefulness and vividness of VR technology have a significant impact on the purchase intention of children room furniture, and the perception plays an intermediary role between VR and purchase intention. In accordance with the research conclusion, VR technology can provide reference for strengthening the application of new technology in furniture industry store exhibition, and can also provide data and a feasible theoretical basis for the furniture sales industry to use VR technology to improve consumers’ purchase intention.

Deep learning-based framework for predicting wind turbine wake flow

Dan Zhou(주단),Hee-Chang Lim(임희창) 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.5

한비자의 법경제사상에 관한 고찰

유위봉,주단 충북대학교 법학연구소 2015 法學硏究 Vol.26 No.1

Into the middle and later periods of the warring states the cruel war was continue happened. Special hegemony war very frequently happen, With the increasing scale of the war, countries face a serious crisis. In this background, the ruler of all countries to safeguard the interests of the state, put forward their own ideas. The props sexual thoughts began as the core. On such social problems at that time, many scholars put forward its own countermeasures and argues that various school of thought contend is also very active. In their exponents legalism is an important school of thought of the spring and autumn period and the warring states era, Early to legalism in the late spring and autumn and the warring states period. After the end of legalism in the confusion of the warring states period seven males and background at the time of the qin state unified national become thoughts. Especially the legalists to the qin country’s political and economic aspects play an important role. And legalist school attaches great importance to the role of the country’s social and economic. Legalism was based on the new army of the basic objectives and tasks of the country is in economic in order to establish a powerful army concentrated social manpower and financial resources for food production. And because of the thought of legalist school national economic activities not only can obtain all kinds of resources and the allocation of resources to help opposite industry. In the midst of figure of legalism, Han Feizi is the master of legalist school. Han Feizi is a master of legalism. Han Feizi founded and claims of target is auxiliary qin legalist theory and to form a new army to manage the state of qin unified qin. Han Feizi new army to rich and strong army, rich countries on the basis of strong soldiers, at the same time new army is Han Feizi the premise of rule of law. Han Feizi thoughts system play an important role in economic thought. On the one hand, today’s China and South Korea are constantly affected by the economic thoughts of Europe and the United States, so more is necessary to study economic thoughts in ancient China. All things are positive and the negative side, economic thoughts in ancient China is no exception, as the change of era and environment play an active role at the same time have some limitations. We are on the analysis of the economic thoughts of ancient at the same time, it is necessary to grasp its double sides. This thesis mainly is the economic thoughts of legalism during the warring states period, especially Han Feizi economic thought as the object, studies the representative figure of legalism, especially to understand Han Feizi legalist school introduction and analysis of work and other economic ideological differences, common ground and positive significance.