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RISS 인기검색어
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- 저자 : 조지연 ( Ji Youn Cho ) (검색결과 2 건)
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정상 위 조직과 위암 조직의 시험관 내 수소자기공명분광
조지연,신운재,최기승,김수현,은충기,양영일,이정희,문치웅,Cho Ji Youn,Shin Oon Jae,Choi Ki Seung,Kim Su Hyun,Eun Choong Ki,Yang Young Il,Lee Jung Hee,Mun Chi Woong 대한위암학회 2003 대한위암학회지 Vol.3 No.3
Purpose: In this study, we attempted to ascertain the proton magnetic resonance spectroscopy (${1}^H$ MRS) peak characteristics of human gastric tissue layers and finally to use the metabolic peaks of MRS to distinguish between normal and abnormal gastric specimens. Materials and Methods: Ex-vivo ${1}^H$ MRS examinations of thirty-five gastric specimens were performed to distinguish abnormal gastric tissues invaded by carcinoma cells from normal stomach-wall tissues. High-resolution 400-MHz (9.4-T) ${1}^H$ nuclear magnetic resonance (NMR) spectra of two gastric layers, a proper muscle layer, and a composite mucosasubmucosa layer were compared with those of clinical 64- MHz (1.5-T) MR spectra. Three-dimensional spoiled gradient recalled (SPGR) images were used to determine the size and the position of a voxel for MRS data collection. Results: For normal gastric tissue layers, the metabolite peaks of 400-MHz ${1}^H$ MRS were primarily found to be as follows: lipids at 0.9 ppm and 1.3 ppm; alanine at 1.58 ppm; N-acetyl neuraminic acid (sialic acid) at 2.03 ppm; and glutathione at 2.25 ppm in common. The broad and featureless featureless spectral peaks of the 64-MHz MRS were bunched near 0.9, 1.3, and 2.0, and 2.2 ppm in human specimens without respect to layers. In a specimen (Borrmmann type III) with a tubular adenocarcinoma, the resonance peaks were measured at 1.26, 1.36 and 3.22 ppm. All the peak intensities of the spectrum of the normal gastric tissue were reduced, but for gastric tumor tissue layers, the lactate peak split into 1.26 and 1.39 ppm, and the peak intensity of choline at 3.21 ppm was increased. Conclusion: We found that decreasing lipids, an increasing lactate peak that split into two peaks, 1.26 ppm and 1.36 ppm, and an increasing choline peak at 3.22 ppm were markers of tumor invasion into the gastric tissue layers. This study implies that MR spectroscopy can be a useful diagnostic tool for gastric cancer.
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Tetracycline을 포접한 Chitin 차페막의 약물 방출특성
한상문 ( Sang Mun Han ),손상현 ( Sang Hyun Son ),조지연 ( Ji Youn Cho ),최한영 ( Han Young Choi ),강병원 ( Byoung Won Kang ),심형진 ( Hyung Jin Shim ),곽병국 ( Byung Kook Kwak ),이승진 ( Seung Jin Lee ) 한국키틴키토산학회 2003 한국키틴키토산학회지 Vol.8 No.1
Chitin은 생체친화성이 높고, 독성을 유발하지 않는다. 본 연구에서는 Chitin을 calcium chloride dihydrate saturated methanol 용액에 녹여 Chitin 차폐막에 양이온성 항생제인 TC을 포접시켜 TC의 용리 특성을 조사하였다. Chitin 차폐막에 포접시켜 칼슘을 제거한 결과 93% 이상 차폐막속에 포접됨을 알았으며 TC 감수성균의 대부분에 대하여 MIC 농도를 유지하면 방출됨을 확인하였다. Chitin is well known that it is biocompatible, biodegradable and nontoxicity. In this study, chitin was dissolved in a novel solvent newly developed, calcium chloride dihydrate saturated methanol solution. The chitin dope casted into a membrane which was subject to adsorption and release tests with tetracycline. Tetracycline which is cationic antibiotic substance was found to be adhered more than 90% to chitin membrane and was released at the level of minimum inhibitory concentration(MIC) against the tetracycline killing microorgrans. It was concluded that controlled release and adherence of any antibiotic substances from or on chitin membrane depend upon their ionic characters(Carboxy1 group of soluble polysaccharide) and salt concentration of eluents.
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