http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
제3차 대한간학회 춘계학술대회 초록집 : 포스터연제 토의 ; Ethylnitrosourea에 의한 마우스 간소엽내 전암병소의 중심정맥주변구역 편향성
이동후 ( Lee Dong Hu ),김병훈 ( Kim Byeong Hun ),이숭환 ( Lee Sung Hwan ),양성규 ( Yang Seong Gyu ),조영중 ( Jo Yeong Jung ),유병무 ( Yu Byeong Mu ),정철헌 ( Jeong Cheol Heon ) 대한간학회 1997 Clinical and Molecular Hepatology(대한간학회지) Vol.3 No.2(S)
김병훈,이동후,이숭환,조영중,양성규,조용현 대한내과학회 2000 대한내과학회지 Vol.59 No.2
Background : Hepatocellular carcinoma(HCC) has characteristic differences in both viral profiles and the most frequently occurring age in each country. It also has clinically distinct features between adult patients of the age under 65 and senile patients over 65 years. Herein we investigate differences in clinical features of the patients with HCC of the three different age groups : young patients (group 1) below 45 years of age; most frequently occurring age (45 - 65 year) (group 2); and elderly patients (group 3) above 65 years of age. Methods : The 371 HCC patients hospitalized and followed-up from 1986 to February 1997 have been analyzed. At the time of diagnosis there was no significant difference among the three groups in alcohol intake, cigarette smoking, sex, family history of liver disease, mean values of aminotransferases, Child-Pugh class, tumor location, TNM stage, tumor size, varix grade, metastasis, abdominal pain, ascites, encephalopathy, fever, or jaundice. Results : In the younger group HCC showed (1) a high incidence of HBsAg positivity (group 1, 95.3%; group 2, 78.6%; group 3, 25%; p$lt;0.001) ; (2) a low positive rate of anti-HCV (group 1, 0%; group 2, 7.7%; group 3, 44.4; p$lt;0.001); (3) a low incidence of NBNC(group 1, 4.9%; group 2, 14.1%; group 3, 30.4%; p$lt;0.01); (4) a high incidence of diffuse type (group 1, 40.5%; group 2, 29.5%; group 3, 11.9%; p$lt;0.05); (5) a higher levels of serum AFP (group 1, 4,180 ng/mL; group 2, 3,224 ng/mL; group 3, 2,025 ng/mL; between group 1 and group 3, p$lt;0.05). But three different levels of AFP ($lt;20 ng/mL, 20-400 ng/mL, $gt;400 ng/mL) showed no differences among the three age groups (p=0.23766). (6) The overall survival rates did not differ statistically among the three groups (mean survival: group 1, 12 months; group 2, 18 months; group 3, 15 months; p=0.4635, log rank test). Conclusion : These data support the younger patients with HCC are the most frequently associated with HBV contrarily to the elderly patients the more frequently associated with HCV or NBNC rather than HBV. This suggests, in turn, that the onset of HCC occurs one or two decades later in those with adult-acquired HCV than it does in lifelong HBV patients after neonatal vertical infection.(Korean J Med 59:142-150, 2000)
만성 간염, 간경변 및 간세포암종 환자 혈청에서 상피성 성장인자 농도의 변동
김병훈,최정혜,김홍주,이동후,조용현,권기운,유용걸,조영중,이제,양성규 대한간학회 1997 Clinical and Molecular Hepatology(대한간학회지) Vol.3 No.1
Background/Aims. Epidermal growth factors (EGF) is known to activate mitogen activated protein kinase (MAP kinase) in hepatocytes by the route of both Raf-dependent and Raf-indefendent pathways. And this is likely to play important role in normal liver cell growth and regeneration. EGF is also reported as a potent mitogen and one of the angiogenic factors. To elucidate the dynamic changes of the serum concentration of epidermal growth factor in chronic liver disease and its correlation with role of EGF and mechanism of tumor development, this study is intended to employ an ELISA in 38 biopsy-proven cases. Methods '. Sera taken out of 5 patients with chronic persistent hepatitis. 4 patients with chronic active hepatitis, 19 patients with liver cirrhosis, 10 patients with hepato- cellular carcinoma that pathological diagnosis was proven later were tested for EGF employing Quantikine ELISA Kits (R & D Systems Inc. Minneapolis, MN). The statistical analysis was evaluated by student's t-test. Results . EGF concentration was 253.33±69.5pg/ml(Mean±SE) in hepatocellular carcinoma, 246.60±91.19pg/ml(Mean±SE) in chronic active hepatitis, 222.71±115.97pg/ml (Mean±SE) in chronic persistent hepatitis, 141.15±23.12pg/ml(Mean±SE) in liver cirrhosis in orders. Serum EGF concentration in hepatocellular carcinoma was significantly higher than that in liver cirrhosis(p value=0.021695). However, comparing to the remaining other groups, no significant difference was found. Conclusion .' These results support that the reconstruction of the capillary networks in liver cirrhosis resplts in down-regulation of the EGF in comparison to chronic hepatitis. But it is suggested that revaluation of EGF stimulates MAP kinase activity eventually playing in tumorigenesis of the liver with neoangiogenesis.
Ethylnitrosourea 에 의한 마우스 간소엽내 전암 병소의 중심정맥주변구역 편향성
김종철,김병훈,정철헌,이동후,이숭환,조용현,조영중,양성규,유병무 대한간학회 1997 Clinical and Molecular Hepatology(대한간학회지) Vol.3 No.3
Background/Aims: Hepatocytes on the hepatic lobule mipate from portal zone to centrilobular mea as the DNA synthesis within it. And also, the xenobiotic reactions reveal characteristic differences associated with zone specific metabolism in the liver acinus. In this study, the zonal distribution of ethylnitrosourea (ENU)-induced hepatic precancerous lesion was stereologically investigated. Methods: Nine B6C3F1 mices were given I.p. injection of ENU (60 ㎍/pn body weight) when the pups were 15 days old prior to sacrifices at 8 weeks of life. All the 150 consecutive sections, 3 p m in thickness, were stained with hematoxylin and eosin and identified the basophilic precancerous lesions with 80-165 p m diameter in equatorial plane by the Zeiss microprojector. And then the distances from the center of selected foci to terminal hepatic vein or portal vein branches were estimated under the microscopic fields. As a control group, the same estimations were performed from the random points by the appointments of random digit table. Results: Mean distance between ENU-induced 52 hepatocellular foci and the nearest terminal hepytic vein was 181.15±112.39 p m (Mean±SD), but that of randomly selected 104 points was 291.73±157.98pm (Mean+5D) (Students t-test, p$lt;0.0005). Substantially, 52.7% of ENU-induced 52 hepatocellular foci were within 300 p m from the terminal hepatic vein, but randomly selected 104 points were only 50.9% (Shapiro Wilk W test, w=0.819857, p=0.048038). Mean distance from ENU-induced 52 foci to portal vein was 398.85±149.98pm (Mean+SD), but that from the randomly selected 104 points was 315.87±145.79 pm (Mean±SD)(Students t-test, p$lt;0.0005). Conclusion: Stereologically, ENU-induced mice liver cell foci distribute non-randomly to Zone III, centrilobular zone of mouse hepatic acini where promote invasion toward terminal hepatic veins. (Korean J Hepatol 1997;6:227 240)