새로운 광학활성보조체를 이용한 비대칭 메칠화반응

정주은(Ju Eun Jung),김희두(Hee Doo Kim) 大韓藥學會 1997 약학회지 Vol.41 No.6

We have synthesized and evaluated (1S, 2R)-1-0-(ethoxycarbonyl)methyl-2,3-0-isopropylidene-1-phenyl-1,2,3-trihydroxypropane(5a) as a novel chiral auxiliary for optically active alpha-hydroxyesters.

청소년의 자율적 통제력과 성인물 노출이 온라인 성적 피해 경험에 미치는 영향

정주은(Ju Eun Jung),이창배(Chang Bae Lee) 한국범죄심리학회 2022 한국범죄심리연구 Vol.18 No.2

이 연구는 청소년의 자율적 통제력과 성인물 노출이 온라인 성적 피해 경험에 미치는 영향을 교육 경험의 조절된 매개효과를 통해 살펴보았다. 청소년이 교육을 통해 스스로 자신이 성적 매체에 노출되는 것을 통제함으로써 온라인에서의 성적 피해 경험에 미치는 경향을 파악하고자 하였다. 구체적으로 자율적 통제력과 생활양식관련이론에 근거한 성인물 노출 수준을 활용하였다. 분석 자료는 여성가족부에서 실시한 「2020 청소년 매체이용 및 유해환경 실태조사」를 활용하였고, 청소년 14,536명을 대상으로 수집한 온라인 성적 피해 경험에 대한 자료를 활용하였다. 분석결과 첫째, 청소년의 자율적 통제력은 성인물 노출 수준을 매개하여 온라인 성적 피해 경험에 유의한 영향을 가지는 것으로 검증되었다. 즉, 청소년의 자율적 통제력이 높을수록 성인물 노출 수준이 감소하고, 낮은 노출 수준은 낮은 온라인 성적 피해 경험으로 이어졌다. 둘째, 자율적 통제력과 노출수준의 관계에서 교육의 조절효과를 분석한 결과 교육을 받지 않은 집단과 교육을 받은 집단이 모두 부적으로 영향을 미치지만, 교육을 받았을 때 자율적 통제력과 노출 수준의 부적관계가 더 강하게 나타났다. 셋째, 자율적 통제력과 온라인 성적 피해 경험의 관계에서 노출수준의 매개효과는 교육 유무에 따라 유의미한 조절효과가 있는 것으로 검증되었다. 마지막으로 연구결과를 바탕으로 청소년들의 온라인 성적 피해를 예방하기 위해 청소년의 자율적 통제력을 높여주고 성인물 노출 수준을 감소시키기 위한 매체이용교육, 예방교육, 성교육 등 다양한 교육 프로그램의 개입 및 발전을 위한 정책적 방안을 제언하였다. This study examined the effect of adolescents' autonomous control and exposure to adult contents on their online sexual victimization experiences via the moderated mediation effect of education experience. The authors purported to investigate if adolescents’ experience of online sexual victimization can be prevented by their willingness to control their exposure to adult contents and by education. Specifically, independent variable autonomous control and exposure to adult contents based on lifestyle-related theory were employed in the analysis models. For the study, we analyzed the "2020 Youth Media Use and Hazardous Environment Survey", which collected by the Ministry of Gender Equality and Family, and the data included the responses from 14,536 teenagers with regard to their online sexual victimization experiences. As a result, first, it was verified that the autonomous control of adolescents had a significant effect on the online sexual victimization by mediating the exposure level. In other words, the higher the autonomous control of adolescents, the lower the exposure level, and the lower the exposure level, the lower the online sexual victimization. Second, as a result of analyzing the moderating effect of education in the relationship between autonomous control and exposure level, both uneducated and educated groups had a negative effect, but the negative relationship between autonomous control and exposure level was stronger when educated. Third, it was verified that the mediating effect of exposure level in the relationship between autonomous control and online sexual victimiation has a significant moderating effect depending on the presence or absence of education. Finally, based on the results, suggestions were made for the intervention and development of various educational programs such as media use education, violence prevention education, and sex education to increase youth's autonomous control and lower exposure levels.

비전 프로세싱을 이용한 학재진압 DARwIn-OP 시스템

이은섭 ( Eun-seop Lee ),이동형 ( Dong-hyung Lee ),김경태 ( Kyeong-tae Kim ),( Adith Jagadish Boloor ),나요안나 ( Amy Wagoner ),정주은 ( Yo-an-na Na ),고석주 ( Ju-eun Jung ),( Seok-joo Koh ),( Eric T. Matson ) 한국정보처리학회 2014 한국정보처리학회 학술대회논문집 Vol.21 No.2

이 논문에서, 우리는 휴머노이드 로봇인 다윈에 내장되어 있는 색 접근법을 이용한 비전 프로세싱을 통해 학재가 난 위치에 접근하며, 적정거리에 도달했을 경우, 다윈의 손에 들고 있는 분무기로 학재를 진압 하도록 하는 “학재진압다윈”을 만들었다. 여러 논문에서 학재진압용 로봇들을 소개하였지만, 우리는 다윈이라는 휴머노이드 로봇을 이용하여 학재를 진압하도록 하였다. 아직까지 휴머노이드 로봇을 실용적으로 사용하기에 많은 문제들이 존재한다. 하지만 휴머노이드 로봇 분야는 사람이 할 수 있는 사다리 타기, 계 단 오르기, 장비 다루기 등과 같은 여러 가지 기능들을 수행할 수 있음으로 많은 잠재력을 가지고 있다. 이번 리서치에서 시도한 학재진압다윈 역시 실용적인 부분에서는 아직 많은 미흡한 점들이 있지만, 미래의 잠재력에 한발자국 나아갔다는 부분에 있어서 많은 의의를 둔다.

호르몬 치료를 받은 한국 폐경 여성에서 발생한 유방암의 임상적 특성

손정빈 ( Jung Bin Son ),정주은 ( Ju Eun Jeong ),주종길 ( Jong Kil Joo ),김기형 ( Ki Hyung Kim ),이규섭 ( Kyu Sup Lee ) 대한폐경학회 2012 대한폐경학회지 Vol.18 No.1

연구목적: 국내 한 병원에서 호르몬 치료를 받은 여성들에게서 발생한 유방암의 위험인자의 비교 및 유방암의 조직학적, 임상적인 특징과 예후 등에 대한 연구를 시행하였다. 연구재료 및 방법: 부산대학교병원에서 폐경으로 인해 호르몬 치료를 받은 여성 중 악성 유방암이 발생한 환자 40명을 대상으로 후향적으로 의무기록지를 통해 조사하였다. 조사 항목으로는 환자군의 병력 및 기초 조사, 받았던 호르몬 치료의 종류와 기간, 호르몬 치료 시작 후 발병까지의 기간, 방사선학적인 특징, 환자의 병기, 조직학적인 진단, 종양의 크기, 조직의 등급, 임파선의 전이 상태, 그리고 에스트로겐 수용체와 프로게스테론 수용체의 유무, 5년 생존율의 여부 등에 대해 조사하였다. 결과: 유방암이 발생한 환자들의 위험요인 조사 항목으로 가족력을 가지고 있던 사람은 1명, 흡연력이 있는 사람은 없었고, 평균 BMI는 23.2 kg/m2로 나타났다. 유방암이 발생한 환자들의 이전 호르몬 치료 종류는 에스트로겐 단일 요일요법을 받은 여성이 12명으로 30%, 에스트로겐 프로게스테론 혼합 요법을 받은 여성이 13명으로 32.5%, 티볼론 요법을 받은 여성이 10명으로 25%였고 기타 환자들에게는 복합적으로 사용되었다. 호르몬의 치료기간은 평균 31 ± 27.9 (0.4-115)개월이었고 호르몬 치료 시작 후 유방암의 발생시간 분포는 1년 이내가 4건 (10%), 1-2년 사이가 5건 (12.5%), 2-3년 사이가 10건 (25%), 3-4년 사이가 4건 (10%), 4-5년 사이가 1건 (2.5%), 5년 이상 16건 (40%)으로 나타났다. 유방암의 평균 직경은 1.7 cm으로 작은 양상을 보이고, 조직학적으로 관암종 형태의 유형이 92.5%로 다수였으며, 병기는 0기와 I기가 66%로 나타났고, 등급으로는 1등급이 38%로 가장 높은 빈도를 보였으며, 호르몬 수용체가 양성인 유방암이 85%로 조사되었고, 임파절 전이는 70%에서 음성, 5년 생존률은 92%로 나타났다. 결론: 호르몬 치료를 받은 폐경기 여성에게서 발생한 유방암은 호르몬 수용체가 양성인 경우가 많으며 크기나 병기가 낮고 저등급의 분화도를 보여 재발이 흔하지 않고 5년 생존률에서 좋은 예후를 보이는 양상을 보였다. Objectives: This study was performed to assess the risk factors, histologic and clinical features of breast cancer in postmenopausal women receiving hormone therapy (HT). Methods: We evaluated 40 breast cancer patients who received HT due to postmenopausal symptoms by reviewing their medical charts at Pusan National University Hospital. Research variables, including patients` history, type and duration of received HT, moment of cancer debut after starting HT, radiological characteristics of breast cancer stage, histologic type, tumor size, grade, lymph node metastasis, estrogen and progesterone receptor status and 5-year survival were investigated. Results: In the risk factors of breast cancer patients, only one patient had familial history of breast cancer. No patient had smoking history. The average body mass index (BMI) was 23.2 kg/m2. Twelve patients (30%) had estrogen only therapy, 13 patients (32.5%) had combined estrogen and progesterone therapy, 10 patients (25%) had tibolone therapy and the others consecutively received combination therapy of the above regimens. The mean duration of treatment was 31 ± 27.9 months (range 0.4-115 months). In the distribution of the cancer debut after starting HT, in 4 cases (10%) was within 1 year, 5 cases (12.5%) within 1-2 years, 10 cases (25%) within 2-3 years, 4 cases (10%) within 3-4 years, 1 case (2.5%) within 4-5 years, and 16 cases (40%) within more than 5 years. The average diameter of tumor size was 1.7 cm. In 92.5% of cases, the tumor was of ductal type. Tumor stage 0 and 1 appeared in 66% and grade I was present in 38% of investigated cases. Hormone receptor-positive breast cancers were 85% and 70% of patients had negative lymph node metastases. The 5-year survival rate was 92%. Conclusion: The breast cancers which emerged during HT in postmenopausal women had hormone receptor-positive tendency. The size and stage of these breast cancers were shown as small and low, and represented low-grade differentiation. Recurrences of disease were uncommon and we found favorable 5-year survival rates and good prognosis.

생흡수성 폴리(PLLA-PGA) 메쉬 트레이와 자가입자망상골 및 늑골을 이용한 편측 하악골 결손의 재건

김철환(Chul Hwan Kim),김훈(Hoon Kim)정주은(Ju Eun Jung) 대한구강악안면외과학회 1999 대한구강악안면외과학회지 Vol.25 No.3

Loss of mandibular continuity can occur secondary to trauma, infection, or tumor resection. The basic goal of mandibular reconstruction is to restore bony continuity, arch form, osseous bulk, acceptable facial form. During the mandibular reconstruction is considered, surgical choices of using autogenous bone are divided into non-vascularized cortico-cancellous bone block graft, vascularized transfer of a cortico-cancellous bone block, and particulate marrow and cancellous bone(PMCB) graft. The PMCB has been successfully used for the reconstruction of mandibular osseous defect since introduced by Boyne, et al. This graft transplants a great density of osteocompetent cells, and promotes an early revascularization with vascular ingrowth with their particulate nature. However, because of their particulate nature, require tray or crib for containing PMCB. The Titanium mesh and Dacron-urethane trays have been used widely for this purpose, and allogenic mandible or rib, ilium have been also used. Recently, bioabsorbable polymer material is used to surgeon for treatment of craniofacial fracture and congenital anomaly of craniofacial skeleton in the form of plate, mesh and screw. In different natures to metal material, secondary operation is unnecessary due to biological degradation and resorption in the body with timing, and it can give adequate strength during the bone healing period. and it can be contoured easily during the operation. Especially, in pediatric applications, it can diminish the possibility of growth disturbance and back-scattering effects diminished when radiation therapy applied. Recently, the literature was reported for jaw reconstruction with PMCB and bioabsorbable polymer tray with animal study. In this case, 18-years old woman, who was diagnosed as ameloblastoma, was shown hemimandibular osseous defects. We performed secondary reconstruction using PMCB from posterior ilium, and rib bone with bioabsorbable poly(PLLA-PGA) mesh as a tray, and some favorable results were obtained and we report it preliminarily, with literature reviews.

폐경 유무에 따른 대사 증후군의 구성 요소와 유병률의 차이

이규섭 ( Kyu Sup Lee ),김승철 ( Seung Chul Kim ),정주은 ( Ju Eun Jung ),주종길 ( Jong Kil Joo ),손정빈 ( Jung Bin Son ) 대한폐경학회 2012 대한폐경학회지 Vol.18 No.3

Objectives: Metabolic and endocrinologic alterations is developed at menopausal transition of women and these alterations can have an effect on prevalence of metabolic syndrome. Therefore, we evaluated the prevalence of metabolic syndrome and differences of components as menopausal status of women who visited our health screening clinic. Methods: We surveyed body sizes, blood pressures and other several blood tests from January 2006 to December 2010 in Pusan National University Hospital by retrospectively reviewing medical records. These results were compared as presence of metabolic syndrome and menopausal status. Differences of the components of metabolic syndrome as the menopausal status and occurrences of metabolic syndrome as the age and the menopausal status are investigated. Results: In premenopausal and postmenopausal women, the prevalence of metabolic syndrome were 8.69% and 21.85%, respectively. More body weight, high body mass index and cholesterol were checked in women who have metabolic syndrome irrespective of menopausal status. Low high density lipoprotein was most prominent component of metabolic syndrome irrespective of menopausal status. Hypertension and high blood sugar were showed meaningful proportions in postmenopausal women. The prevalence of metabolic syndrome was unrelated to the menopausal status by regressively analyze, but meaningfully increased related to aging. Conclusion: Menopausal alterations restrictively effect on occurrence of metabolic syndrome and aging is more effect on it. But more detailed and additional studies are needed about determining the relation of metabolic syndrome in women who surgically menopaused and receiving hormone therapy. (J Korean Soc Menopause 2012;18:155-162)

폐경 여성에서 타목시펜 사용 후 발견된 거대 자궁내막용종

문수현 ( Soo Hyeon Moon ),이성의 ( Seong Eui Lee ),정인국 ( In Kook Jung ),정주은 ( Ju Eun Jeong ),박원영 ( Won Young Park ),이우희 ( Woo Hee Yi ),서동수 ( Dong Soo Suh ),윤만수 ( Man Soo Yoon ),김기형 ( Ki Hyung Kim ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.12

Tamoxifen is a synthetic non-steroid anti-estrogen that has been used effectively for several years in the adjuvant treatment of breast cancer. But, the drug has been associated with development of endometrial poylp, hyperplasia and adenocarcinoma possibly mediated through its agonistic estrogen properties during the menopausal period in which estrogens are at a low level. Endometrial polyp has been described as the most common endometrial pathology in association with postmenopausal tamoxifen treatment. We present the case of woman with a giant endometrial polyp of uncommon dimension who was receiving adjuvant tamoxifen for 5 years after breast cancer surgery.

한약재 열수 추출물의 변이원 및 항변이원 활성의 검색

강미영,남석현,정주은 한국농화학회 1999 Applied Biological Chemistry (Appl Biol Chem) Vol.42 No.4

The mutagenicity, antimutagenicity, and cytotoxicity of the hot water extracts of 130 medicinal plants were examined. The results obtained using authentic alkaline phosphatase activity as the growth representative of the indicator cell, E. coli PQ37, demonstrated that the extracts of 14 medicinal plants including, Forsythia koreana Nakai, showed strong toxic effect on the cell growth, however, the extracts of 22 medicinal plants, including Phlomis umbrosa Turcz., were shown to have stimulatory effect on the cell growth. The mutagenicity and antimutagenicity of the medicinal plants were screened using SOS chromotest. The mutagenic activity was detected from 36 kinds of the samples, including Forsythia koreana Nakai and Coptis japonica Nakai. On the contrary, 12 medicinal plants, including Crataegus pinnatifida Bunge, were shown to have a significant antimutagenic activity.