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Anti-acne Properties of Artemisia annua Extract In Vitro
유지영,노경백,오세영,정용택,박덕훈,정은선,You, Jiyoung,Roh, Kyung-Baeg,Oh, Se-young,Jung, Yong-Taek,Park, Deokhoon,Jung, Eunsun Society of Cosmetic Scientists of Korea 2021 대한화장품학회지 Vol.47 No.3
여드름은 털피지샘단위(pilosebaceous unit)와 관련된 만성 염증 피부 질환으로, 여드름 병변에서는 피지 과다분비(hyperseborrhea)나 이상분비(dysseborrhea), 염증반응, 그리고 다른 피부상재균들에 비해 증가된 Cutibacterium acnes (C. acnes)로 인한 피부 미생물 균총의 불균형이 관찰된다. 이 연구는 개똥쑥 추출물(Artemisia annua extract: AAE)의 항여드름 효과를 확인한 것으로, 피부 미생물 균총의 균형유지와 관련된 항균효과와 염증반응의 억제, 과도한 피지 분비의 감소 측면에서 실험을 진행하였다. C. acnes와 Staphylococcus epidermidis(S. epidermidis)를 AAE와 공동배양 하였을 때, S. epidermidis의 성장률은 저해되지 않았지만 C. acnes의 성장률은 저해된 것을 확인하였다. 또한 AAE를 처리하여 배양한 C. acnes 배양배지를 세포에 처리하였을 때, 인터루킨-1β(IL-1β), 종양괴사인자-α(TNF-α)와 인터루킨-6(IL-6) 같은 사이토카인 분비의 감소와 TLR2 활성 억제도 확인하였다. 마지막으로 피지세포에 AAE를 처리한 결과, 팔미트산에 의해 유도된 피지형성을 감소시키는 것을 확인하였다. 이 결과들은 AAE가 다양한 타깃을 지닌 천연추출물로써 여드름의 주요 원인들인 C. acnes의 선택적 성장저해와 C. acnes로부터 유도되는 염증반응을 억제할 수 있으며, 과도한 피지형성을 감소시켜 결과적으로 여드름을 완화시키는 물질로 사용될 수 있다는 것을 제시한다. Acne vulgaris is a chronic inflammatory skin disease related to pilosebaceous unit. In acne lesions, hyperseborrhea, dysseborrhea, inflammatory event, and an imbalance in skin microflora, particularly an increase in Cutibacterium acnes (C. acnes) colonization comparing to other bacteria, have been observed. The objective of this study was to evaluate anti-acne effects of Artemisia annua extract (AAE) on antibacterial activity related to preservation of the balance in skin microbiome, inhibition of inflammation, and reduction of excessive sebum production. When C. acnes and Staphylococcus epidermidis (S. epidermidis) were co-cultured in the presence of AAE, the reduction of C. acnes growth by AAE was greater than that of S. epidermidis. In addition, when C. acnes was cultured in a medium containing AAE (C. acnes AAE), levels of cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and IL-6 and toll-like receptors-2 activity were decreased in comparison with C. acnes cultured in a medium without AAE (C. acnes CM). Moreover, AAE significantly inhibited excessive sebum production induced by palmitic acid. These results suggest that AAE, as a natural extract with various targets, can inhibit selective growth of C. acnes and inflammatory reactions derived from C. acnes, which are the main causes of acne, and consequently can be used as a substance to alleviate acne by reducing excessive sebum formation.
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홍성철(Sung-Chul Hong),조혜미(Hye-Mee Jou),조태진(Tae-Jin Cho),이치원(Che-Won Lee),정용택(Yong-Taek Jung),손부순(Bu-Soon Son) 대한환경위생공학회 2008 대한환경위생공학회지 Vol.23 No.2
In order to recommend criteria for the administration law on indoor air quality, this study was conducted to examine the distribution and the concentration of indoor air pollutants (PM₁?, CO₂, CO, HCHO, TBC, NO₂, Rn, VOCs, asbestos, O₃) in public facilities in the Chung-Nam area. The concentrations of indoor air pollutants were obtained from sixty seven public facilities such as a cinema, an office, a restaurant, a theater and an academy. This study was performed from August to December, 2005. The results of this study showed that the concentrations of indoor air pollutants such as PM₁?, CO₂, CO, HCHO, TBC, Rn and O₃ were less than the recommended limits. However, the average concentration of VOCs was 521.73㎍/㎥ (GM : 221.69㎍/㎥), which was higher than the recommended limit of 400 ㎍/㎥. Moreover, the average concentration of NO₂ was 345.66ppb (GM : 69.95ppb), which was higher than the recommended limit of 50 ppb. The correlation between the concentrations of indoor air pollutants and the type of facilities with respect to CO₂, TBC and Rn was statistically low (p<0.05). However, the correlation was high in terms of the CO and O₃ concentrations (p<0.01). No relationship between the indoor air pollutants and the type of facilities was observed for PM₁?, VOCs and NO₂. The year of construction was compared to the concentrations of indoor air pollutants. Specifically, when the construction date was less than 3 years, the HCHO, VOCs and TBC concentrations were 44.75 ㎍/㎥, 555.07 ㎍/㎥and 337.79 CFU/㎥, respectively. These concentrations were 120 ㎍/㎥and 211.84 CFUl㎥ higher for VOCs and TBC than the concentrations obtained from the facilities more than 3 years. However, the concentration of HCHO was similar between the facilities older and younger than 3 years of age. Year, temperature, humidity and indoor air pollutant correlation analyses showed that temperature and humidity, temperature and TBC, temperature and O₃, PM₁? and NO₂, HCHO and VOCs, CO₂ and Rn had positive relationships. However temperature and Rn, humidity and CO₂, CO₂ and O₃, Orand Rn had negative relationships. Accordingly, it will be necessary to manage the factors affecting indoor air quality so that the residents can have a more comfortable and healthier living environment. Ultimately, the results of this study are expected to be utilized as baseline data.
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