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흰쥐에서 당뇨 유도 후 하악골 골밀도 변화에 관한 연구
정석영(Seok-Young Jeong),신상훈(Sang-Hun Shin),김욱규(Uk-Kyu Kim),박봉수(Bong-Soo Park),정인교(In-Kyo Chung) 대한구강악안면외과학회 2002 대한구강악안면외과학회지 Vol.28 No.2
DM is a systemic disease with many complications. One of them, diabetic osteopenia is important sequelae and many authors reported reduced bone mass in diabetic rats. However, in mandible, study has been rare because of its anatomical limits. So the objective of this study was to investigate bony change in mandible of diabetic rats. Thirty-two adult rats were used in this study. Half of them were male and female respectively. In sixteen rats, streptozotocin was injected intraperitoneally to induce DM and the serum glucose concentration was checked to ensure the induction of DM prior to the time of sacrifice. At 1, 2, 3, 4, 6, 8, 12, 16weeks, control group and diabetic group rats were sacrificed respectively. And then bone mineral density of mandibles and femurs of the rats was measured using dual energy X-ray absorptiometry(DEXA). In addition serum osteocalcin and urine deoxypyridinoline were measured as markers of bone formation and resoption respectively. Mandibular and femoral bone density in streptozotocin induced rats was decreased with significance statistically after 4 weeks from injection. In mandible, comparing with femur, bone density was moderately decreased. The alveolar bone in mandible was more decreased bone density than the whole body in the mandible From these results, bone mineral density decreased in uncontrolled diabetic group with time, and especially alveolar bone was more destructive in the mandible. So authors think that consideration of reduced bone mineral density is necessary in dental procedure.
증례(症例) : 급성기 병변을 보인 지연성 저산소성 뇌병증
임미혜 ( Mi Hye Lin ),정석영 ( Seok Young Jeong ),오선영 ( Sun Young Oh ),정슬기 ( Seul Ki Jung ),서만욱 ( Man Wook Seo ),김영현 ( Young Hyun Kim ),신병수 ( Byoung Soo Shin ) 전북대학교 의과학연구소 2007 全北醫大論文集 Vol.31 No.1
Delayed postanoxic encephalopathy is a rare complication of hypoxic events. The underlying pathological lesion is thought to be progressive diffuse demyelination in the cerebral white matter. It is difficult to predict and diagnosis such sequelae early. We presents a 76-year-old woman who showed abnormal behavior and memory impairment due to delayed hypoxic demyelination with a serially performed diffusion weighted MRI imaging (DWIs) and 1H-MRS at initial insult of CO poisoning and after the appearance of delayed sequelae. We proposed that the DWIs of acute stage of insult can be considered as predictor for delayed postanoxic demyelination.