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          Serum Amyloid A as a Useful Indicator of Disease Activity in Patients with Ankylosing Spondylitis

          정상윤,박민찬,박용범,이수곤 연세대학교의과대학 2007 Yonsei medical journal Vol.48 No.2

          Purpose: To investigate whether serum amyloid A (SAA) levels are increased in patients with ankylosing spondylitis (AS) and whether its levels correlate well with AS disease activity. Materials and Methods: Thirty-eight patients with AS and 38 age- and sex-matched control subjects were enrolled in this cross-sectional study. Their SAA levels were quantitatively measured by immunonephelometry. An established, self-administered instrument for evaluating disease activity (Bath Ankylosing Spondylitis Disease Activity Index, BASDAI) was used to measure and acute phase reactants, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), in patients with AS. Results: Patients with AS had a significantly higher mean SAA level than controls (9.52±7.49mg/L versus 2.73±1.57mg/L, p<0.05), and the mean BASDAI score of patients with elevated SAA levels was significantly higher than that of patients with normal SAA levels (5.6±1.3 versus 4.4±1.5, p<0.05). SAA levels showed significant correlations with BASDAI scores (r=0.431, p=0.007), ESR (r=0.521, p=0.001) and CRP levels (r=0.648, p<0.001). Additionally, the correlation between ESR and CRP levels also appeared significant (r=0.703, p< 0.001). In those with normal ESR or CRP levels, SAA levels and BASDAI scores were elevated (p<0.05) and showed a trend of positive correlation with one another. Conclusion: Our data showed that SAA levels were increased in patients with AS and correlated well with disease activity. These findings suggest that SAA can be used as a valuable indicator of disease activity in AS.

        • KCI등재
        • KCI등재

          Molecular and Cellular Basis of Neurodegeneration in Alzheimer’s Disease

          정상윤 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.9

          The most common form of senile dementia is Alzheimer’s disease (AD), which is characterized by the extracellular deposition of amyloid -peptide (A) plaques and the intracellular formation of neurofibrillary tangles (NFTs) in the cerebral cortex. Tau abnormalities are commonly observed in many neurodegenerative diseases including AD, Parkinson’s disease, and Pick’s disease. Interestingly, tau-mediated formation of NFTs in AD brains shows better correlation with cognitive impairment than A plaque ac-cumulation; pathological tau alone is sufficient to elicit frontotemporal dementia, but it does not cause AD. A growing amount of evidence suggests that soluble A oligomers in concert with hyperphosphorylated tau (pTau) serve as the major pathogenic drivers of neu-rodegeneration in AD. Increased A oligomers trigger neuronal dysfunction and network alternations in learning and memory circuitry prior to clinical onset of AD, leading to cognitive decline. Furthermore, accumulated damage to mitochondria in the course of aging, which is the best-known nongenetic risk factor for AD, may collaborate with soluble A and pTau to induce synapse loss and cognitive impairment in AD. In this review, I summarize and discuss the current knowledge of the molecular and cellular biology of AD and also the mechanisms that underlie A-mediated neurodegeneration.

        • KCI등재후보

          디지털 전환 시범사업에 대한 평가 연구 -울진, 강진, 단양 지역을 중심으로-

          정상윤 부산울산경남언론학회 2012 지역과 커뮤니케이션 Vol.16 No.1

          Korea is expecting a very important business which is called Digital TV transition. For this nationwide project scheduled to be finished by December 31, 2012, not only cooperation of audiences, but also well-prepared policy is needed. However, there are many political and technical issues remained to be improved or supplemented for this conversion. For example, some studies show that people in korea have lower awareness about digital transition than people in Japan and England. Moreover, the rate of digital set-up box prevalence in Korea is not enough. This article aims at three issues to clarify. First, I studied the pilot project in three regions of Uljun, Gangjin and Danyang area researched in 2010. Second, I analyzed and evaluated the effect of the pilot project on the basis of 'in-depth interviews' and survey results with natives and chairmans of the Audiences' Support Center. Third, I suggested policy issues which need to be elaborated for the successful digital TV transition. As a result of study, I pointed out four important policy issues to be prepared by government. At first, more effective way of PR about digital TV transition has to be planned for the audiences. Second, high skilled manpower is crucial to accomplish the nationwide project. As a third, policy makers should establish policies for the 'pay-TV audiences' who are not prepared for the digital TV transition. Finally, role of KBS as a public broadcasting system is essential to reduce the fringe area. 디지털 전환은 국가적으로 매우 중요한 사업 중의 하나이다. 특히 디지털 전환을 성공적으로 완수하기 위해서는 국민들의 적극적인 협조와 정부의 치밀한 계획이 필요하다. 그러나 2012년 12월 31일 디지털 전국 전환을 앞두고 있는 지금 아직까지도 정책적으로 개선하거나 보완해야 할 사항이 많이 남아있다. 더구나 우리나라 국민들의 디지털 방송 수신기 보급률과 아날로그 방송 종료 인지율 등은 영국이나 일본에 비해 낮은 편이다. 본 연구는 울진, 강진, 단양군에서 2010년에 실시한 디지털 전환 시범사업 내용을 살펴보고, 성과를 평가 분석함으로써 디지털 본 전환에 대비하여 준비해야 할 사항들을 제시하였다. 이를 위해 시범사업이 진행되는 기간에 주민들과 시청자 지원센터장 등을 심층면접하였으며, 한국리서치에서 실시한 설문분석 자료를 참고하였다. 연구결과 난시청 해소를 위한 노력이 필요하며, 지역적 특성을 고려한 인지경로를 파악하여 보다 체계적인 홍보활동을 하는 것이 필요한 것으로 나타났다. 그리고 컨버터 지원 및 안테나를 개보수하기 위한 전문 인력을 충분히 확보해야 하며, 시청자 지원센터의 적극적인 활동을 통해 민원율을 낮추도록 하는 것이 바람직하다. 뿐만 아니라 유료방송 가입자들을 대상으로 하는 디지털 전환 정책이 마련되어야 한다. 마지막으로 성공적인 디지털 전환을 위해서는 정부, 시청자, 방송사의 역할이 중요하다. 그 중에서도 특히 KBS의 역할은 아무리 강조해도 지나치지 않는다. KBS는 국가의 기간방송으로 난시청을 해소하고 수신환경을 개선해야 하는 의무를 지니고 있기 때문이다.

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