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Urinary Profiles of the Endogenous Steroids in Pre-Menopausal Women with Uterine Leiomyoma
정병화,배상욱,정봉철,김세광,박기현,Jung, Byung-Hwa,Bai, Sang-Wook,Chung, Bong-Chul,Kim, Sei-Kwang,Park, Ki-Hyun The Korean Society for Reproductive Medicine 2003 Clinical and Experimental Reproductive Medicine Vol.30 No.1
목 적: 본 연구의 목적은 내인성 성호르몬이 자궁근종의 성장에 미치는 영향을 알아보고자 연구를 시행하였다. 연구대상 및 방법: 폐경전 자궁근종 환자 27명과 같은 연령대의 정상여성 25명을 대상으로 하였다. 모든 대상군의 여성에서 24시간 소변을 모아서 소변내 estrogen, androgen의 대사체들을 GC-MS를 이용하여 측정하였으며 두 군에서의 차이를 비교분석 하였다. 결 과: 소변내 $17{\beta}$-estradiol, 5-androstene-$3{\beta}$, $16{\beta}$, $17{\beta}$-triol, 11-keto-ethiocholanolone, $11{\beta}$-hydroxy-androsterone, THS, THA, THE, a-cortolone, a-cortol 및 $\beta$-cortol가 환자군에서 의의있게 증가하였으며 $17{\beta}$estradiol/estrone 및 $11{\beta}$-hydroxy-ethiocholanolone/$11{\beta}$-hydroxy-androsterone도 환자군에서 의의있게 증가하였다. 결 론: 자궁근종의 성장은 요중 estrogen과 androgen의 농도와 밀접한 관련이 있으며 이는 환자의 스테로이드 호르몬 대사 감소에 기인한 것으로 사료된다.
시각화된 스키마 생성기를 이용한 데이터 웨어하우스의 실체 뷰 생성
정병화(Byung-Hwa Jung),이현창(Hyun-Chang Lee),김경창(Kyung-Chang Kim),지원철(Won-Chul Jhee) 한국정보과학회 1998 한국정보과학회 학술발표논문집 Vol.25 No.2Ⅰ
데이터 웨어하우스 시스템은 의사 결정의 지원에 필요한 요약, 분석 작업을 수행하여 다양한 고품질의 정보 서비스를 사용자에게 제공한다.[1] 이러한 데이터 웨어하우스에 사용자가 질의를 요철할 경우 다차원 모델을 고려해 보면 여러 테이블을 조인해야 할 경우가 발생하고 이때 방대한 양의 사실 테이블을 가지고 있는 데이터 웨어하우스는 질의 처리시 성능 저하를 초래 할 수 있다. 그러므로 본 연구에서는 사용자의 질의에서 자주 요구되는 집계사실을 미리 저장하여 데이터 웨어하우스에 대한 질의 처리 성능 향상을 기대할 수 있도록 집계사실이 저장될 효율적인 집계 테이블 생성에 따른 설계와 구현을 한다. 이를 수행하기 위해 본 논문에는 집계 사실의 저장방법에 대해 살펴보고, 집계 계획에 근거한 집계 테이블 생성 인터페이스의 프로토타입 설계 및 구현을 살펴본다. 이렇게 함으로서 사용자의 의사 결정에 필요한 정보를 데이터 웨어하우스에서 더욱 신속하게 얻을 수 있다.
저 전압 SoC를 위한 문턱전압 근처에서 동작하는 Bootstrapped CMOS Differential Logic Family
정병화(Byung-Hwa Jung),김종우(Jong-Woo Kim),강성찬(Sung-Chan Kang),공배선(Bai-Sun Kong) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.11
This paper describes a novel bootstrapped CMOS differential logic style (or use in ultra-Iow voltage SoCs. The proposed logic style provides a higher switching speed than conventional differential logic styles for driving a large capacitive loader the supply voltage less than 0.6V. This is achieved by enhancing the switching speed of transistors using the bootstrapping technique. Test circuits were designed using a 0.18m CMOS process technology. The comparison results indicate that the proposed logic style achieves up to 40% improvement on switching speed as compared to conventional CMOS differential logic family for the supply voltage less than 0.6V. They also indicate that the proposed logic family retains the advantage of better switching performance for increased load capacitance and fan-in number.
정병화(Byung Hwa Jung),이선화(Seon Wha Lee),김태욱(Tae Wook Kim),정봉철(Bong Chul Chung),박종세(Jong Sei Park) 대한약학회 1993 약학회지 Vol.37 No.4
The metabolic profile of carbinoxamine, 2-[(4-chlorophenyl)-2-pyridinyl-methoxy] N, N-dimethylethanamine, was determined in rat urine. Urinary extracts obtained with or without enzyme hydrolysis were derivatized with MSTFA/TMSCI (N-methyl-N-trimethylsilyl trifluoroacetamide/Trimethylchlorosilane) and analyzed by GC/MSD. In rat urine, which obtained after oral treatment with carbinoxamine maleate, chlorobenzolyl pyridine, (4-chlorophenyl)-2-pyridinyl methanol : carbinol, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N-methylethanamine : norcarbinoxamine, 2-[(4-chlorophenyl)2-pyridinylmethoxy]ethanamine : bis-norcarbinoxamine and parent carbinoxamine were detected in free form. Norcarbinoxamine and bisnorcarbinoxamine were also detected in conjugated form(acetylation). These data suggest that in the rat, hydroxylation of either the benzyl or pyridinyl ring can occur during carbinoxamine elimination. O-demethylation and subsequent conjugation represents the primary pathway of carbinoxamine elimination in the rat.
정병화(Byung Hwa Jung),엄기동(Khee Dong Eom),유영숙(Young Soo Yoo),정봉철(Bong Chul Chung),박종세(Jong Sei Park) 대한약학회 1992 약학회지 Vol.36 No.1
The metabolic profile of triprolidine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl-1-propenyl)] pyridine, was determined in rat urine and bile. The free fractions of urinary and biliary extracts were obtained without hydrolysis, and the conjugated fractions of extracts were obtained with enzyme hydrolysis using beta-glucuronidase from Escherichia coli. The mixture of N-methyl-N-trimethylsilyltrifluoroacetamide/trimethylsilyl choloride(100 : 1, v/v) was used to derivatize the extracts and then anaylzed by gas chromatography/mass spectrometry. Hydroxymethyltriprolidine, hydroxytriprolidine, triporolidine carboxylic acid, dihydroxytriprolidine 1, dihydroxytriprolidine 2, oxotriprolidine carboxylic acid and unchanged triprolidine were detected in rat urine and bile, which were obtained after oral treatment with triprolidine hydrochloride. The maximum urinary excretion rate of triprolidine and hydroxymethyltriprolidine which were extracted from free fraction was at 1 to 2 hours after drug administration . Hydroxymethyltriprolidine was detected in conjugated fraction, and the maximum urinary excretion rate of that metabolite was at 2 to 3 hours in rat. In rat bile analysis, triprolidine was detected only in free fraction and its biliary excretion rate showed the maximum within 30 minutes after drug administration and decreased continuously thereafter. The excretion percentage of triprolidine and hydroxymethyltriprolidine to the initial dose of the parent drug in bile and urine of rats were all low.