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      • KCI등재후보

        Effects of Indomethacin on Ischemia-induced Brain Injury

        정두열(Doo-Yeoul Jung),백선용(Sun-Yong Baek),조민경(Min-Kyoung Cho),한명은(Myoung-Eun Han),김봉선(Bong-Seon Kim),김재봉(Jae-Bong Kim),오세옥(Sae-Ock Oh) 대한해부학회 2007 Anatomy & Cell Biology Vol.40 No.3

        뇌허혈은 삶의 질을 상당히 파괴하는 장애를 야기하는 질환이다. 현재의 치료법은 심각한 장애를 극복할 수 있을 정도로 효과적이지는 못하다. 새로운 효과적인 치료법을 개발하기 위해서는 뇌손상 부위의 미세환경을 이해할 필요가 있다. 본 연구에서는 뇌허혈에 의한 염증성 반응의 역할을 구명하기 위하여 광유도 혈전증(photothrombosis)에 의한 뇌경색 동물모델에서 항염증제인 indomethacin의 효과를 연구하였다. 본 연구에서 뇌허혈은 뇌실밑지역(subventricular zone), 과립세포밑지역(subgranular zone), 허혈성 경계영역에서 신경발생과정(neurogenesis)을 정상 쥐에 비해서 유의한 수준으로 증가시켰다. Indomethacin 투여는 이러한 뇌허혈에 의해 유도되는 신경발생과정을 86.2%, 53.8%, 52.8%씩 각각 감소시켰다. 허혈성 경계영역에서 뇌허혈은 혈관신생과정(angiogenesis)과 신경아교증(gliosis)을 정상 쥐에 비해서 유의한 수준으로 증가시켰다. 뇌허혈에 의한 이러한 신경아교증과 혈관신생과정의 증가를 indomethacin 투여는 각각 48.2%, 58.1% 감소시켰다. 이상의 결과는 뇌허혈 시 indomethacin의 처리는 신경발생과정, 혈관신생과정 및 신경아교증을 감소시킬 수 있다는 것을 의미한다. Cerebral ischemia can have severe results and disrupt quality of life. Current medicine is not effective at overcoming these problems. To find out more effective therapies, it is necessary to understand the microenvironment of cerebral injury after the ischemia. In the present study, to investigate the effects of inflammatory reaction, indomethacin, an anti-inflammatory drug, was used in a photothrombotic focal infarction rat model. It was revealed that cerebral ischemia increased neurogenesis in the subventricular (SVZ) and subgranular zones (SGZ), and in the penumbral region. Indomethacin treatment reduced the cerebral ischemia-induced neurogenesis by 86.2%, 53.8%, and 52.8% respectively. Cerebral ischemia increased gliosis and angiogenesis in the penumbral region and indomethacin reduced gliosis and angiogenesis by 48.2% and 58.1%, respectively. These results suggest that indomethacin treatment after the cerebral ischemia can reduce neurogenesis, angiogenesis, and gliosis in the penumbral region.

      • SCOPUSKCI등재

        위축성 병변을 보인 Pigmented Dermatofibrosarcoma Protuberans ( Bednar Tumor )

        이종호 ( Jong Ho Lee ),정두열 ( Doo Yeoul Jung ),이숙경 ( Sook Kyung Lee ),이원우 ( Won Woo Lee ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.1

        A Bednar tumor is a variant of dermatofibrosarcoma protuberans(DFSP). The clinical and histopathological findings of Bednar tumors are identical to DFSP except for the presence of melanin-containing cells scattered within the lesion, so called pigmented DFSP. The majority of Bednar tumors are seen as DFSP present as multinodular protuberant masses in the skin. They can also present as an atrophic depressed scar-like lesions without any nodularity. We report an uncommon clinical presented case of a Bednar tumor on the back in a 22-year-old female. She presented with an asymptomatic, firm, bluish, chestnut sized, depressed and atrophic lesion on the back which had been present for 6 years. A Histopathological examination revealed massive proliferation of spindle-shaped cells arranged in a tight storiform pattern mixed with scattered pigmented cells. On immunohistochemical staining, the tumor cells were positive for vimentin, a -l-antitrypsin, and CD34, but were negative for cytokeratin, neurofilament, and factor XIIIa. The majority of the tumor cells was negative and the pigment cells were positive for the S-100 protein. The patient was treated by a wide local excision of the lesion. There has been no evidence of recurrence after 20 months post-operative follow up. (Korean J Dermatol 1998;36(1): 139-142)

      • SCOPUSKCI등재

        악성 에크린 한공종 1예

        이숙경,이원우,배주한,정두열 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.5

        Malignant eccrine poroma, or eccrine porocarcinoma, is a rare malignant cutaneous appendageal tumor arising from the intraepidermal eccrine sweat duct(acrosyringium), and usually develops ia an eccrine poroma of long-standing. We report a case of malignant eccrine poroma on the left buttock in a 72 year-old female. She was presented with a slightly pruritic, well-defined, reddish, firm, 4.5 x 4.5 x 0.7cm sized, protruding, ulcerated tumor. Histopathological examination revealed well-defined tumor cell nests in the epidermis and dermis. The tumor nests consisted of areas of eccrine poroma cells with benign appearance adjoining areas of anaplastic cells. Duct-like structures were observed within the tumor nests and showed a PAS-positive, diastase-resistant reaction. On immunohistochemical staining, the tumor cells were, positive for EMA, and most of tumor cells were negative but the duct-like structures were positive for CEA. She was treated with surgical excision. During the three year follow up period after excision, there was no recurrence.

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