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자궁경부암에서 싸이클로옥시게나제의 발현과 방사선치료 효과와의 관계
전용탁,강순범,이효표,송용상,서상수,김재원,박노현 대한부인종양학회 2006 Journal of Gynecologic Oncology Vol.17 No.2
Objective: The aim of this study is to clarify the relationship between COX expressions and radioresistance in cervical cancer. Methods: Patients with cervical cancer treated by primary radiotherapy were selected from the tumor registry of our institution. According to the response to radiotherapy, poor responder and good responder was defined. Immunohistochemical staining was performed using monoclonal anti-COX-1, 2 antibodies. Cell lines derived from human cervical tumors were used: HeLa, HT3, and C33A. Using western blot, COX-1, 2 expressions were identified in each cell line. The sensitivity of the cervix cancer cells to radiation was measured using a clonogenic assay. Results: COX-1 and COX-2 expressions were higher in poor responders than good responders. The difference of COX-1 expression between two groups had marginal statistical significance (p = 0.099, Fisher’s exact test) and COX-2 expression was significantly higher in poor responders (p = 0.034, Fisher’s exact test). In the clonogenic assay, survival fraction of HeLa and HT-3 cell lines, which have COX-1 and COX-2 activity, was significantly higher than C33A cell line which has no COX activity (p < 0.001). Conclusion: Our results suggest that the expression of COX in cervical cancer might be deeply associated with the effect of radiation therapy. 목적: 자궁경부암에서 싸이클로옥시게나제의 발현과 방사선치료에 대한 반응성 사이의 관련을 알아보고자 하였다. 연구방법: 자궁경부암으로 방사선치료를 받은 환자들 중 방사선치료에 대한 반응이 좋지 않았던 11명의 환자와 방사선치료에 대한 반응이 좋았던 11명의 환자를 선택하였고, 보관된 암 조직에 대하여 싸이클로옥시게나제-1,2의 발현을 면역조직화학염색을 통하여 알아보았다. 또한, 세 가지 자궁경부암 세포주 (HeLa, HT-3, C33A)에 대하여 Western blot을 통해 싸이클로옥시게나제-1,2의 발현을 확인하고 싸이클로옥시게나제의 발현 차이에 따라 방사선 감수성의 변화가 있는지 clonogenic assay를 통하여 알아보았다. 결과: 면역조직화학염색 결과 싸이클로옥시게나제-1의 발현은 방사선치료에 대한 반응이 좋지 않았던 군에서 많이 발현되었으나 통계적 유의성은 높지 않았다 (p = 0.099, Fisher’s exact test). 싸이클로옥시게나제-2의 발현은 방사선치료에 대한 반응이 좋지 않았던 군에서 유의하게 많이 발현되었다 (p = 0.034, Fisher’s exact test). Western blot에서 HeLa와 HT-3 세포주는 싸이클로옥시게나제-1,2가 모두 발현되는 것을 알 수 있었고, C33A 세포주는 싸이클로옥시게나제의-1,2의 발현이 없었다. Clonogenic assay에서는 HeLa와 HT-3 세포주의 생존 분율이 C33A 세포주보다 유의하게 높았다 (p < 0.001). 결론: 본 연구를 통하여 자궁경부암에서 싸이클로옥시게나제의 발현은 방사선치료 자체에 대한 저항성과 깊은 관련이 있을 가능성을 확인하였다.
전용탁 ( Yong Tark Jeon ),양혜진 ( Hye Jin Yang ),손영수 ( Young Soo Son ),지병철 ( Byung Chul Jee ),김용범 ( Yong Beom Kim ),박교훈 ( Kyo Hoon Park ),서창석 ( Chang Suk Suh ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.10
Vaginal and cervical agenesis is an uncommon Mullerian anomaly. Total hysterectomy and vaginoplasty remains the classical treatment of this malformation. We present a case of reconstruction of utero-neovaginal continuity in the patient with normal functio
세부 전공에 따른 자궁경부상피내종양의 처치로써 환상투열 절제술에 대한 태도 분석
전용탁 ( Yong Tark Jeon ),민경준 ( Kyung Joon Min ),지병철 ( Byung Chul Jee ),김용범 ( Yong Beom Kim ),박교훈 ( Kyo Hoon Park ),서창석 ( Chang Suk Suh ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.3
목적: 부인종양 전임의 과정을 거친 산부인과 전문의와 그렇지 않은 경우에 있어서 자궁경부상피내종양의 처치로써 환상투열 절제술 (LLETZ)에 대한 태도에 차이가 있는지를 알아보고자 하였다. 연구 방법: 2003년 6월부터 2004년 9월까지 분당서울대학교병원 산부인과에서 LLETZ를 시행한 81명의 환자를 대상으로 하였다. LLETZ와 질확대경하 조직생검 소견을 의무기록을 통해 조사하였고, 부인종양학 전임의 과정을 거친 의사에게 시술을 받은 군 (GO Objective: The aim of this study is to compare the clinician`s attitude to the large loop excision of transformation zone (LLETZ) according to the subspecialty; gynecologic oncology or not. Methods: Eighty-one patients who had LLETZ at Seoul National Univ
자기공명영상에 의한 자궁내막암의 자궁근층 , 자궁경부 침윤 판별과 수술적 병기와의 비교
전용탁(Yong Tark Jeon),황규리(Kyu Ri Hwang),김재원(Jae Weon Kim),박노현(Noh Hyun Park),송용상(Yong Sang Song),강순범(Soon Beom Kang),이효표(Hyo Pyo Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
N/A Objective : The aim of this study was accuracy evaluation of MRI in prediction of myometrial, cervical invasion in endometrial carcinoma by comparing with histopathologic findings and to find causes of inaccurate MRI readings. Method : Fifty patients with endometrial carcinoma who were evaluated with MRI imaging prior to surgery were reviewed. And then, we compared MRI findings and histopathologic findings in view of myometrial, cervical invasion. Results : Overall accuracy of MRI in prediction of myometrial invasion was 48%. Sensitivity/specificity/ PPV/NPV in prediction of no myometrial invasion were 100%/42.9%/42.9%/100% respectively, in prediction of superficial myometrial invasion were 20.0%/86.7%/50.0%/61.9% respectively, in prediction of deep myometrial invasion were 33.3%/94.3%/71.4%/76.7%, respectively. Accuracy in prediction of cervical invasion was 84% and sensitivity/specificity/PPV/NPV were 50.0%/88.6%/37.5%/92.9% respectively. Among the probable causes of inaccurate MRI readings, polypoid tumor occupies large portion. Conclusion : MRI has some value in pre-operative evaluation of patients with endometrial carcinoma. We should cautiously accept the MRI readings when tumor shows polypoid growth.
긴장성 요실금의 수술적 치료에서 Tension-free vaginal tape (TVT)과 Transobturator tape (TOT)의 효과에 대한 예비 보고
전용탁 ( Yong Tark Jeon ),황태기 ( Tae Gi Hwang ),민경준 ( Kyung Joon Min ),지병철 ( Byung Chul Jee ),김용범 ( Yong Beom Kim ),박교훈 ( Kyo Hoon Park ),서창석 ( Chang Suk Suh ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.5