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김용범 ( Yong Beom Kim ),전용탁 ( Yong Tark Jeon ),서상수 ( Sang Soo Seo ),김재원 ( Jae Weon Kim ),박노현 ( Noh Hyun Park ),송용상 ( Yong Sang Song ),강순범 ( Soon Beom Kang ),이효표 ( Hyo Pyo Lee ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.4
목적 : 최근에 그 효용성이 확대되고 있는 DNA chip을 이용하여 우리나라 자궁경부암 환자에서 발견되는 고위험군 HPV 감염 빈도와 아형의 분포를 알아보고 동시에 자궁경부암의 각 조직병리학적 종류에 따라 발견되는 고위험군 HPV 아형의 빈도와 분포에 따른 차이의 여부를 알아보고자 하였다. 연구 방법 : 1998년 2월부터 2001년 2월까지 서울대학교병원 산부인과에서 자궁경부암 (FIGO stage Ⅰa1-Ⅱa)으로 자궁절제술 혹은 근치적 자궁절제술 Objective : To evaluate the prevalence and genotype of high risk HPV infection with oligonucleotide microarray based DNA chip in cervical cancer. Methods : The presence of HPV and its type were tested with oligonucleotide microarray based DNA chip in 84 s
클로미펜으로 배란을 유도한 여성에서 발생한 양측 난관임신
김성우 ( Sung Woo Kim ),강민지 ( Min Ji Kang ),이유경 ( Yoo Kyung Lee ),김재원 ( Jae Weon Kim ),박노현 ( Noh Hyun Park ),송용상 ( Yong Sang Song ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.11
Bilateral simultaneous tubal pregnancy is a rare clinical event. The estimated incidence of bilateral simultaneous tubal pregnancy is 1/200,000 of live births following natural conception and 1/725 to 1/1,580 of all extrauterine pregnancies. Recently, the incidence has increased, because both pelvic inflammatory disease and the use of assisted fertility have become more common. We report a case of bilateral tubal pregnancy managed with unilateral salpingectomy and conservative methotrexate treatment in woman with ovulation induction by clomiphene citrate.
자기공명영상에 의한 자궁내막암의 자궁근층 , 자궁경부 침윤 판별과 수술적 병기와의 비교
전용탁(Yong Tark Jeon),황규리(Kyu Ri Hwang),김재원(Jae Weon Kim),박노현(Noh Hyun Park),송용상(Yong Sang Song),강순범(Soon Beom Kang),이효표(Hyo Pyo Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
N/A Objective : The aim of this study was accuracy evaluation of MRI in prediction of myometrial, cervical invasion in endometrial carcinoma by comparing with histopathologic findings and to find causes of inaccurate MRI readings. Method : Fifty patients with endometrial carcinoma who were evaluated with MRI imaging prior to surgery were reviewed. And then, we compared MRI findings and histopathologic findings in view of myometrial, cervical invasion. Results : Overall accuracy of MRI in prediction of myometrial invasion was 48%. Sensitivity/specificity/ PPV/NPV in prediction of no myometrial invasion were 100%/42.9%/42.9%/100% respectively, in prediction of superficial myometrial invasion were 20.0%/86.7%/50.0%/61.9% respectively, in prediction of deep myometrial invasion were 33.3%/94.3%/71.4%/76.7%, respectively. Accuracy in prediction of cervical invasion was 84% and sensitivity/specificity/PPV/NPV were 50.0%/88.6%/37.5%/92.9% respectively. Among the probable causes of inaccurate MRI readings, polypoid tumor occupies large portion. Conclusion : MRI has some value in pre-operative evaluation of patients with endometrial carcinoma. We should cautiously accept the MRI readings when tumor shows polypoid growth.
박상신 ( Sang Shin Park ),박노현 ( Noh Hyun Park ),김민아 ( Min A Kim ),정연경 ( Youn Kyoung Chung ),김민정 ( Min Jung Kim ),강석범 ( Sok Bom Kang ),김재원 ( Jae Weon Kim ),송용상 ( Yong Sang Song ),강순범 ( Soon Beom Kang ),이효 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.2
Primary ovarian carcinoid tumors usually arise in association with gastrointestinal or respiratory epithelium, which is present in mature cystic teratoma. One case of carcinoid tumor arising from ovarian mature cystic teratoma is presented with a brief re
이상은 ( Sang Eun Lee ),송용상 ( Yong Sang Song ),강석범 ( Sok Bom Kang ),정연경 ( Youn Kyung Chung ),김문홍 ( Moon Hong Kim ),주웅 ( Woong Ju ),이성숙 ( Seung Sook Lee ),박인애 ( In Ae Park ),김용범 ( Yong Beom Kim ),김재원 ( Ja 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.8
목적: 외음부암에서의 표피성장인자수용체 (epidermal growth factor receptor, EGFR)의 발현 정도를 알아보고 외음부암 환자의 임상 변수들과의 상관성을 살펴본다. 연구 방법: 1991년 2월부터 2003년 1월 동안 서울대학병원과 국립암센터에서 치료 받은 환자들 중 외음부암으로 진단 받은 28명을 그 대상으로, 환자에서 얻은 조직을 면역조직화학요법으로 EGFR의 발현을 관찰하고 환자의 의무기록을 열람하여 관련된 임상 정보를 수집 Objective: The aim of this study was to evaluate the expression of epidermal growth factor receptor (EGFR) in vulvar malignancies and to determine if a correlation exists between EGFR levels and various clinical variables. Methods: Between 1991 and 2003,
자궁경부암에서 자궁경부-질 세척액과 혈청 내의 IL-8과 VEGF의 농도에 대한 환자-대조군 연구
김용범 ( Yong Beom Kim ),전혜원 ( Hye Won Jeon ),서상수 ( Sang Soo Seo ),김재원 ( Jae Weon Kim ),박노현 ( Noh Hyun Park ),송용상 ( Yong Sang Song ),강순범 ( Soon Beom Kang ),이효표 ( Hyo Pyo Lee ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.4
목적 : 자궁경부암의 발생 및 진행에 관련이 있는 것으로 알려지고 있는 cytokine 중에서 종양에 대한 숙주의 면역반응, 종양의 진행 및 침윤성의 확보에 관여할 것으로 생각되고 있는 IL-8와 VEGF에 대하여 환자군과 정상 대조군의 혈청과 자궁경부-질 세척액으로부터 농도를 측정하여 비교하고자 하였다. 연구 방법 : 침윤성 자궁경부암으로 자궁절제술을 받을 예정인 환자 14명과 자궁근종 등으로 수술을 시행할 예정인 환자 19명에서 말초 혈액 및 자궁경 Objective : The aim of this study was to evaluate the concentration of IL-8 and VEGF in serum and cervicovaginal washing fluid and to investigate whether local production of IL-8 and VEGF could be found. Methods : Cervicovaginal washing fluid and sera wer
유상영(Sang Young Ryu),강순범(Soon Beom Kang),이철민(Chul Min Lee),김재원(Jae Won Kim),박노현(Noh Hyun Park),송용상(Yong Sang Song),이효표(Hyo Pyo Lee) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12
N/A From Jan. 1984 to Dec. 1993, 46 patients with malignant germ cell tumor of ovary were identified in tumor registry of Seoul National University Hospital. The clinicopathologic features of these patients were reviewed. The mean age of patient was 21.6 years (range 1-54), and common presenting symptoms were abdominal mass (19/46), abdominal pain (9/46), abdominal distension (7/46), and epigastric discomfort (2/46) in order. Dysgerminoma was the most common histologic type (19/46, 41.3%), followed by endodermal sinus tumor (13/46, 28.2%), mixed germ cell tumor (6/46, 13/0%), embryonal carcinoma(5/46, 10.8%), immature teratoma(2/46, 4.3%), and chorio- carcinoma (1/46, 2.1%). Among 6 mixed germ cell tumors, dysgerminoma mixed with endodermal sinus tumor component was the most frequent combination. Fifty percent of patients were with FIGO stage I, and 26% with stage III. Overall two year disease free survival was 89.1%. Patients with dysgerminoma showed more favorable 2 year disease free survival (100%) than endodermal sinus tumor or mixed germ cell tumor (84.6%, 66.6% respectively). Patients age, disease stage, histologic type and future child-bearings should be considered in the management of malignant ovarian germ cell tumor. Multicenter prospective randomized studies are needed to identify the more rational treatment strateges of these rare malignant tumors.
김석현,송은섭,송용상,이경희,김정구,문신용,이진용,장윤석,Kim, Seok-Hyun,Song, Eun-Seop,Song, Yong-Sang,Lee, Kyung-Hee,Kim, Jung-Gu,Moon, Shin-Yong,Lee, Jin-Yong,Chang, Yoon-Seok 대한생식의학회 1991 Clinical and Experimental Reproductive Medicine Vol.18 No.2
Recently the application of gonadotropin-releasing hormone (GnRH) agonist to superovulation in previous poor responders has resulted in the improved outcomes after in vitro fertilization (IVF) outcome. However, poor responders with poor estradiol $(E_2)$ rise or single dominant follicle are a particularly challenging group. Recent reports have also shown that patients with higher basal serum follicle stimulating hormone (FSH) level, result in poorer ovarian response and lower pregnancy rate. Analysis of the differences of superovulation outcomes according to the different protocols of GnRH agonist, long (L, n = 18) and short (S, n = 16) protocols, in patients with high basal FSH levels (>20mIU/ml) were undertaken at Seoul National University Hospital from June to October 1990. The administration of GnRH agonist was begun on day 21 of the cycle in long protocol, and on day 2 in short protocol. Ages of patients and husbands, basal FSH and luteinizing hormone (LH) levels and FSH/LH ratio did not differ significantly. Types and causes of infertility were evenly distributed. Whereas the duration of stimulation and the amounts of gonadotropins administered were significantly reduced in short protocol, the numbers of oocytes retrieved and cleaved, the cleavage rate and the number of embryos transferred were higher in long protocol without statistical signifieance. The pregnancy rate per ET was 16.7% (2/12) in short protocol, and 17.6% (3/17) in long protocol. These data suggest that both protocols result in the similar superovulation outcomes in patients with higher basal serum FSH levels.