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전오배,강신영,심태섭 중앙대학교 의과대학 의과학연구소 1981 中央醫大誌 Vol.6 No.1
The soil-transmitted and contagious helminthes, such as Ascaris lumbricoides, whipworm, hookworm and pinworm are the commonest and the most widespread human parasites in Korea. However, the first intestinal nematode infection has been taken into account as the great endemic parasitic disease in this country. Data cited from KAPE(korean Association for Parasite Eradication) were analyzed on the bases of infection rate, fertilized ova passers/unfertilized ova passers and the evaluation of the effect of mass control on primary school-children during the past 10 years from 1969 to 1978. The results were summarized as follows: 1) The overall prevalence of Ascaris infection was decreased from 57.1% in 1969 to 22.8% in 1978 and the cumulative percent of decrease during that period was 34.3% and the mean annual decrease rate represented as 3.8%. 2) The cumulative rate of decrease in primary school children was in the range of 32.2-36.8% by school year. 3) The prevalence of Ascaris infection of primary school-children in rural area was 60% in 1969, it decreased to 17-30% in 1978, while the rates tangibly dropped to about 10% level in urban primary-school children. 4) The positive rate of A. lumbricoides in 1973 was composed of fertilized and unfertilized ova passers in the ratio of 43.l% :9.2% (F/U=4.68). Five years later in 1978 it changed to 3.22. 5) By applying the present results to the statistical model of Hayashi(1977), the theoretical infection rate per month and cure rate per treatment were computed as 2.54% and 33.3% respectively in primary-school children during the past 10 years. And the observed data were coincide with the theoretical data. From the above statistical analyses, it is distinct that the prevalence and F/U ratio remarkably decreased by efficient mass control on primary school children during the past 10 years from 1969 to 1978.
까치살무사독이 흰쥐 심장에 미치는 영향에 관한 병리학적 연구
전오배,송계용,심태섭 중앙대학교 의과대학 의과학연구소 1987 中央醫大誌 Vol.12 No.1
For the elucidation of mechanism of cirulatory collapse in acute venom intoxication,an experimental studies was carried out for the cardiotoxic effect of rat myocardium using the venom of Agkistrodon saxailis. The rat used were adults weighing between 200∼250gm. 40mg of freeze dried venom was diluted to 12ml of normal saline, and 0.4ml of this solution was administrated intravenously through tail vein to each rat. The rats were sacrificed serially with time interval; after venom adminstration 1 hour, 3 hours, 6 hours,1 day, 4days and 7 days, respectively. The hearts were immediately prepared for light and electron microscopy. Additionally serum enzymes, namely glutamic oxaloacetic transaminase(GOT), lactic dehydrogenase(LDH) and creatinine phosphpkinase(CPK)were measured for the associated chamges. The results obtained were as follows: 1. Light microscopic changes in the heart revealed moderate to marked congestion, edema and hemorrhage in the ventricular and subendocardial myocardium with coagulation necrosis of myocardial muscles in the hemorrhagic areas were infiltreated with a few inflammatory cells in 3∼6 hours. Thereafter fibrosis was due in the areas of necrosis. 2. Early electron microscopic changes in the myocardium revealed marked intracellular edema with lifting, bleb formation and repture of sarcolemma as well as separation of myofilaments and focal random loss of myofilaments. Mitochondrial swelling and vacuolar changes were also seen. 3. Serum levels of GOT were significantly elevated in 3 hours to 312.5±213.6IU/ℓ(p<0.05) until 6 hours to 376.7±283.5IU/ℓ(p<0.01). 4. Serum levels of LDH were significantly reduced in 24 hours to 508.1±269.0IU/ℓ(p<0.01) until 4 days to 453.4±190.3IU/ℓ(p<0.01). 5. Serum levels of CPK were significantly reduced in 24 hours to 306.1±205.1IU/ℓ(p<0.01) until 4 days 532.1±457.8IU/ℓ(p<0.05). Summarizing the above results, it was suggested that cardiotoxicity of the venom of Agkistrodon saxailis, characterized by marked myocardial edema and hemorrhage with necrosis, could play a role in explaining acute cirulatory collapse in rats. It was also interesting to note that the extent of myocardial damage did not parallel to the levels of serum glutamic oxaloacetic transaminase, lactic dehydrogenase and creatinine phosphpkinase.