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Hippo-YAP/TAZ pathway regulation: the crucial roles of lncRNAs in cancer
장원이,임미정,노정욱,강지훈,김완연 한국통합생물학회 2023 Animal cells and systems Vol.27 No.1
The Hippo signaling pathway is a conserved signaling pathway that regulates cell proliferation,apoptosis, and differentiation and plays essential roles in the maintenance of organ size andtissue homeostasis. Also, this signaling pathway is a critical regulator of malignant progressionin a wide range of cancers. Furthermore, it has been established that YAP and TAZ are majoreffectors of the Hippo signaling pathway and transcription co-activators that regulate theexpressions of genes involved in cell growth and differentiation. Long non-coding RNAs(lncRNAs) are transcripts longer than 200 nucleotides involved in several biological processes,including chromatin remodeling, transcriptional regulation, and post-transcriptional processing. Evidence suggests that the aberrant expression and dysregulation of lncRNAs contribute to thedevelopment and progression of various malignancies by acting as oncogenes or tumorsuppressors. In addition, many studies have shown that lncRNAs can directly or indirectlyregulate the Hippo-YAP/TAZ signaling pathway in cancer. Here, we overview the roles played bylncRNAs in tumor progression with focus on their regulation of the Hippo-YAP/TAZ signalingpathway and discuss their potential usages as clinical biomarkers and therapeutic targets.
건강증진 프로그램 효과에 영향을 미치는 프로그램 관련 요소 분석 - 문헌고찰을 중심으로 -
장원기,정경래,김철웅 한국보건행정학회 2002 보건행정학회지 Vol.12 No.1
To find out more efficient ways of implementing health promotion programs and to determine the factors affecting the results of various interventions, we reviewed 73 articles on the effectiveness of health promotion programs. These include the papers on the smoking, alcohol, drug abuse, nutrition(obesity) and stress management etc. Specific interventions evaluated in this review are education based on the lecture or video shows, health-related event activities, modifications of policy or the environment, health risk appraisal etc. By using KIHASA Line of Korea Institute of Health and Social Affairs, National Congress Library Database and MEDLINE, we identified 201 articles published from 1980 to Jun. 1999 and finally selected 73 papers which contain the implementation process, and result of each program. The factors used in the analysis of the programs are (1) characteristics of participants (2) interventions evaluated (3) research design (4) length of programs and evaluation point (5) outcome indices (6) effect of program evaluated by each author. The study results did not prove positive effect of education based on lectures or video shows etc. Rather, it was suggested that lecture-based education has negative effect on the result. Event activity such as contest or health festivals has positive effect, and policy change or environmental change is closely related to the event activity. Also, the result shows that the overall effect of programs for the students is less than that of the programs for the others. The programs conducted over 1-year are more likely to have positive outcomes than shorter ones. And, the outcomes of the programs with controlled research design such as experimental or quasi-experimental study tend to be evaluated inferiorly to those with non-experimental design.