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Fully automated ethanolic loop synthesis of the [11C]OMAR
장근삼,송호천 대한방사성의약품학회 2016 Journal of radiopharmaceuticals and molecular prob Vol.2 No.2
We have successfully synthesized of 4-cyano-1-(2,4-dichlorophenyl)-5-(4-[11C]methoxyphenyl)-N-(piperidin-1-yl)1H-pyrazole-3-carboxzmide ([11C]OMAR), which has been shown a progressing candidate to human brain PET study, from fully automated loop method using ethanol as the only solvent for the entire manufacturing process. The radiochemical yield of [11C]OMAR was observed in 4.1 ± 0.2 % with 4990 ± 384 Ci/mmol of the specific activity and total synthesis time was about 45 minutes after HPLC purification (n = 3, decay corrected) from ethanolic loop system, which was exhibited to better results compared with conventional methods. Ethanolic loop chemistry is favorable and efficient method by simplifies manufacturing procedures as well as satisfied suitable for human administration. J Radiopharm Mol Probes 2(2):137-142, 2016
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이성식,장근삼,이병철,오영호,박성욱,김동우,장기형,이성열 대한화학회 2019 Bulletin of the Korean Chemical Society Vol.40 No.9
Quantum chemical analysis is presented to elucidate the origin of difference in the reactivity of aliphatic vs. aromatic guanidine-containing pharmaceuticals toward [18F]fluorination. We focus on the position (near to or far away from the site of reaction) of F? nucleophile in pre-reaction complexes, as determined by intricate interplay of the Coulombic forces between the ionic species and hydrogen bonding with the ?Boc protected guanidine. In [18F]fluorination of aliphatic guanidine compounds, the freely moving nucleophile F? is positioned close to the site of fluorination irrespective of the length of side chain, in agreement with the observed similar reaction yields for ?CH2OMs and ?CH2CH2CH2OMs side chains. As for the effects of positions of ?Boc protection, we predict that the effects would to be contrary to the corresponding aromatic case, with the N, N?-bis-Boc protected guanidine compound being much more reactive than the N, N?-bis-Boc protected guanidine compound.
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박영식,심하몽,나명환,송호천,윤상후,장근삼,Park, Young Sik,Shim, Ha-Mong,Na, Myung Hwan,Song, Ho-Chun,Yoon, Sanghoo,Jang, Keun Sam 한국통계학회 2014 응용통계연구 Vol.27 No.4
최근 휴대단말기 시장에서는 블루투스, GPRS, EDGE, 3GSM, HSDPA 등과 같은 높은 대역폭의 RF를 사용하고 있다. 높은 대역폭의 RF 영역에서는 높은 면저항(Sheet resistance)을 갖는 무전도 금속박막 코팅 방법이 사용되고 있는데, 기존의 무전도 금속증착은 사출물 세정, UV 하도 코팅, 금속증착, UV 중도 코팅, 상도 코팅 등 다수의 복합 공정으로 이루어져 있다. 특히 하도공정은 금속 증착(Sputtering)과 일괄 처리가 어려워 생산성이 낮고 생산원가 상승의 원인이기도 하다. 따라서 이를 극복하기 위하여 최근 Na 등 (2014)은 무전도 금속코팅에서 Primer 대체를 위한 전자빔의 표면처리의 가능성을 가능함을 보였다. In this paper, 플라즈마 생성 전자빔 소스(Plasma generated electron beam source)를 활용하여 PC/ABS 수지 사출물의 공정을 실험계획법에 의한 전자빔 조사 조건을 탐색하여, 즉, 수지 표면처리공정 조건을 탐색하여, 그 실험 결과를 분석하여, 진공전처리공정 개발 및 양산공정라인의 처리의 최적 조건을 찾고자 한다. High bandwidth RF such as Bluetooth, GPRS, EDGE, 3GSM, HSDPA is papular in the mobile phone market. A non-conducting metal coating process requires an e-beam deposition of metal, two steps of UV hard coating primer and top coating; however, it is inefficient. We navigate to the electron beam irradiation conditions(resin surface treatment conditions) in the PC/ABS resin injection process. By analyzing the experimental results, we find the optimum development conditions for the electro deposition pre-treatment process and mass production lines using the plasma generated electron beam source.
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Dae Yoon Chi,Jae Hak Lee,Uthaiwan Sirion,장근삼,이병세 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.12
Hydroxylation of primary and secondary alkyl halides and alkyl sulfonates was readily achieved by one-pot two-step reaction under mild condition. Less reactive chloride and secondary mesylate functionalities were also transformed to hydroxide group in high yields. When 5% water-containing DMSO solvent was used, catalytic cycle of two-step hydroxylation smoothly proceeded in the presence of catalytic amount of acetate anion.
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