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웃음요법이 수면장애를 가진 재가노인의 수면에 미치는 효과
이임선(Lee, Yim Sun),박효정(Park, Hyojung) 기본간호학회 2021 기본간호학회지 Vol.28 No.3
Purpose: The purpose of this study was to examine the effect of laughter therapy on the quality and quantity of sleep in elders with sleep disorders. Methods: This was a quasi-experimental study using a non-equivalent control group pretest-posttest design with 59 participants and included elders with sleep disorders, The Pittsburgh Sleep Quality Index (PSQI) scores of five or more points were: 29 in the experiment group and 30 in the control group. The experimental group participated in laughter therapy sixteen times, twice a week for 50 min per session for 8 weeks. Results: The results showed that laughter therapy was effective according to the PSQI (F=86.13, p<.001), total sleep time (F=9.34, p<.001), sleep efficiency (F=45.34, p<.001), sleep onset latency in the experimental group x²=13.77, p=.001, and in the control group x²=11.95, p=.003), number of awakenings (F=31.21, p<.001), light sleep (F=5.09, p=.008), deep sleep (F=15.13, p<.001), and serum melatonin levels (Z=-3.90, p<.001). but rapid eye movement sleep time did not differ significantly between the groups. Conclusion: The results of the study indicate that laughter therapy may be an effective nursing intervention to improve quantity and quality of sleep in community-dwelling elderly.
웃음요법이 퇴행성 슬관절염 노인의 관절통증, 관절기능상태, 우울에 미치는 효과
이임선(Yim Sun Lee),박효정(Hyo Jung Park) 한국산학기술학회 2020 한국산학기술학회논문지 Vol.21 No.9
본 연구는 웃음요법이 퇴행성 관절염 노인 환자의 관절 통증, 관절기능 이상, 우울에 주는 효과를 확인하기 위해 시도되었다. 단일맹검, 무작위 배정을 통해 S시의 경로당 및 복지관을 이용중인 65세 이상 퇴행성 슬관절염 노인을 대상으로 실험군 26명, 대조군 26명을 선정하였다. 2019년 1월 8일부터 3월 11일까지 주 2회, 회당 60분, 8주, 총 16회의 웃음요법을 적용하고 그 효과를 VAS, 압통역치, WOMAC, 한국형 노인 우울 단축형 척도로 측정하였다. 연구결과 퇴행성 슬관절염 노인의 통증 역치(p =.012)와 통증, 관절경직, 신체기능을 측정하는 관절기능상태(p <.001), 우울(p <.001)은 대조군에 비해 실험 후 개선되어 웃음요법이 효과가 있음이 확인되었다. 웃음요법은 육체적 또는 지적 활동을 통해 웃음을 경험할 수 있는 치료적 개입으로 침습적인 시술이 이루어지지 않고 약간의 훈련으로 간호사들이 쉽게 적용할 수 있는 장점이 있으므로 웃음요법을 지역사회 및 임상 현장에서 퇴행성 슬관절염 노인의 통증을 완화시키고 우울을 개선하는 중재방법으로 활용할 수 있을 것으로 사료된다. This study examined the effects of laughter therapy in the elderly with degenerative arthritis who had joint pain, joint dysfunction, and depression. Through a single-blind, randomized assignment, an experimental group of 26 subjects and a control group of 26 subjects were recruited among the elderly with degenerative knee arthritis, who were over 65 years of age. From January 8 to March 11 of 2019, a total of 16 laughter therapies were administered two times a week, 60 minutes per session, in eight weeks. The pain threshold (p =.012) and joint function status (p <.001), which represents the pain, joint stiffness, and physical function, and depression (p <.001), in the experimental group improved after the eight weeks laughter therapy compared to the control group. Laughter therapy is a therapeutic intervention that can be delivered through physical or intellectual activities. This therapy is a non-invasive procedure and has the advantage that nurses can practice easily with a little training. It can be used as an intervention within community and clinical settings to relieve pain and improve depression in the elderly with arthritis.
눈꽃동충하초 (Paecilmyces japonica DGUM 32001) 균사배양물의 항암 효과에 관한 유세포분석학적연구
이지선(Ji-Seon Lee),이임선(Im Seon Lee),정경수(Kyeong-Soo Chung),김용해(Yong Hae Kim),한영환(Young Hwan Han),이만형(Man Hyong Lee) 대한약학회 2001 약학회지 Vol.45 No.1
Protein-polysaccharide fractions, PJ-3 and PJ-4, were prepared from mucelial culture filtrate of an insect fungus, Paecilomyces Japonica DGUM 32--1, and subjected to a flow cytomerical analysis for their in vivo antitumor and immunomodulating activity in ICR mice. When I.p. injected once daily for seven days at 100mg/kg, PJ-4 exerted a strong antitumor activity, showing the growth inhibition ratio of 85.1% against I.p.implanted sarcoma 180 cells, while PJ-3 showed only a weak activity. Moreover, PJ-4 significantly increased the expression level of CD25 (IL-2R alpha-chain) as well as forward scatter (FSC) values of splenic CD8+ T cells. It is also noteworthy that PJ-4 strongly induced the peritoneal exudate cells in the same experiment. In an in virto study, PJ-4 slightly inhibited the growth of sarcoma 180 sells at toe consentration of 50 concentration of 50ug/ml or higher. These results strongly suggest that PJ-4 might exert its antitumor activity through immunostimulation as well as direct inhibitory activity on the tumor cells.