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RISS 인기검색어
- 검색키워드
- 저자 : 유혜경(Hae Kyoung Yoo) (검색결과 5 건)
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만성 B 형 활동성 간염에서 Ara - AMP 의 효과
유혜경(Hae Kyoung Yoo),서동진(Dong Jin Suh) 대한내과학회 1987 대한내과학회지 Vol.32 No.6
N/A Thirty six HBeAg positive patients with biopsy proven chronic active hepatitis were treated with Ara-AMP (15 mg/kg/day IV for 7 days followed by 5 mg/ kg/day IM for 21 days). 54 patients with HBeAg positive chronic hepatitis were followed without treatment as controls, Nineteen (52.8%) treated patiens lost serum HBeAg. However, four of them became HBeAg positive again during a mean observation peroid of 13 months. Spontaneous clearances of HBeAg were observed in thirteen (24.1%) controls over a similar period. Patients with higher pretreatment SGPT values and more severe histologic abnormalities tended to respond to Ara-AMP better. Side effects of Ara-AMP were transient and mild. It is suggested that Ara-AMP injection for 4 weeks would be effective for the treatment of chronic ative hepatitis, type B.
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B 형 간염백신의 효과 - 접종부위에 따른 면역성의 차이 -
이창홍(Chang Hong Lee),박영태(Young Tae Park),유혜경(Hae Kyoung Yoo),이명석(Myung Seok Lee),문해란(Hae Ran Moon) 대한내과학회 1987 대한내과학회지 Vol.32 No.4
N/A The efficacy of a highly purified, formalin inactivated hepatitis B vaccine (Hepavax-B®), 20ug of surface antigen (HBsAg), given at 0, 1, and 6 months, was evaluated in 83 healthy young volunteers (mean age;25 years old) according to the injection sites of vaccine. All three doses had been given by arm injections in 51 subjects (A group) and the remainders (22 subjects) had received buttock injections for the first 2 doses followed by third-dose arm injections (B group). A significant decrease in seroconversion was noted 6 months after first dose injections in B group male subjects (31%) comparing with B group females and A group males and females, but conversion rate was rapidly elevated (95%) shortly after third-dose arm injections in these subjects. Geometrical mean antibody levels expressed as ratio units (RU) were significantly low 6 months after first dose injections in B group (both female % male) (p<0.005 vs. A group). This difference between A & B group was disappeared by the rapid increase of antibody level in B group subjects 2 months after third-dose injections, but in comparison with females, mean antibody level of male subjects was still significantly low in B group (p<0.005). Overall antibody conversion rates were over 95%, and antibody levels were above 10 RU in 90% of responders in both A & B groups 2 months after third-dose injections. Subjects with antibody levels above 100 RU were 65% in A group responders at the same time. In conclusion, as a method of hepatitis B vaccination, arm seems to be a superior site of injection to buttock even in young persons whose expected antibody responses are known to be excellent.
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B 형 간염 바이러스에 의한 간질환에서 혈청 B 형 간염 바이러스 DNA 의 검출 양상
박영태(Young Tae Bak),이창홍(Chang Hong Lee),유혜경(Hae Kyoung Yoo),문해란(Hae Ran Moon),최규완(Kyoo Wan Choi),김경호(Kyong Ho Kim) 대한내과학회 1987 대한내과학회지 Vol.33 No.3
N/A Serum HBV-DNA was measured by spot hybridization technique in 189 cases with HBsAg positive acute and chronic liver diseases, HBV-DNA was detected in 62% (68/110) of HBeAg positive, in 16% (10f62) of anti-HBe positive, and in 18% (3/17) of both HBeAg and anti-HBe negative patients. Cases with higher levels of HBV-DNA among HBeAg positive patients were significantly more than those among the HBeAg negative patients, Among the HBeAg positive patients, HBV DNA was detected in 36% of AVH, 86% of healthy carriers, 63% of CPH, 62% of CAI-l-m, 58% of CAH-s, 65% of LC, and 71% of HCC. Among the HBeAg positive patients, those with histologically minimal or mild inflammatory change (healthy carrier, CPH, CAH-m) had higher levels of HBV-DNA, and those with histologically greater inflammatory or destructive change (CAH-s, LC, HCC, AVH) had lower levels of HBV-DNA. Above results suggest that detection of serum HBV- DNA in patients with HBV-related liver diseases may be useful to evaluate the degree of viral replication and infectivity and to predict the histological severity and relative prognosis.
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내과영역의 감염에 대한 Cefmetazole sodium의 임상관찰
이명석,이병호,이윤석,유혜경,강경호,박승철 대한화학요법학회 1986 대한화학요법학회지 Vol.4 No.2
Cefmetazole sodium is recently developed semisynthetic cephalosporins that is highly-stable in physicochemical structure. This antibiotic has a broad bacteriostatic and bactericidal effects, especially against. β-lactamase producing bacteria. We perform clinical trial of Cefmetazole sodium on 20 cases of various infections, such as repiratory tract infection, intraabdominal infection, urinary tract infection and other infection. The following conclusive results are in this study; 1) The overall efficacy of Cefmetazole sodium in various infection reveals good. (75%) 2) Cefmetazole sodium is highly effective against infection of Staphylocccus, E. coli, Klebsiella, Acinetobacter. (100%) 3) Any specific side effect is not noted except mild nausea and indigestion in one case.
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서동진,이명석,유재명,유혜경 대한내과학회 1986 대한내과학회지 Vol.31 No.2
Congenital choledochal cyst is a rare developmental anomaly and the increased incidence of carcinoma arising in it has been emphasized by several investigators. We report a case of congenital choledochal cyst associated with adenocarcinoma with reviewing some literatures. A 46-yr-old female patient complaining intermittent epigastric discomfort and palpable mass in RUQ area for 10 years was diagnosed to have congenital choledochal cyst by Abdominal sonogram, Abdominal CT, PTC, and associated carcinoma was confirmed on the wall of resected cyst.
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