골다공증성 척추 압박 골절 환자에서 새로운 척추 골절 발생의 위험 인자

유성림,고영도,최신우 대한척추외과학회 2017 대한척추외과학회지 Vol.24 No.4

Study Design: A retrospective study. Objectives: To investigate the risk factors associated with new compression fractures in patients with osteoporotic vertebral compression fractures. Summary of Literature Review: Previous studies have reported that a history of osteoporotic vertebral fractures and decreased bone mineral density were risk factors for new compression fractures. It is not certain whether vertebroplasty is a risk factor for new compression vertebral fractures. Materials and Methods: This retrospective study included a total of 52 patients who were diagnosed with an osteoporotic vertebral compression fracture and could be followed up for at least 1 year. Age, sex, bone mineral density, body mass index, osteoporosis treatment, fat infiltration of the back muscles, the sagittal index, vertebroplasty, and underlying diabetes mellitus or hypertension were compared between patients who developed new compression fractures during 1 year of follow-up and those who did not. For statistical analysis, the t-test and chi-squ are test were used to analyz ethe relationship of each factor with osteoporotic vertebral compression fracture incidence, and multiple logistic regression analysis was performed to analyze multifactorial explanatory factors. Results: No significant differences were found between the 2 groups regarding sex, underlying disease, the sagittal index, and fat infiltration of the back muscles. Patients who developed a new compression fracture were significantly older (p=0.011), had a lower body mass index (p=0.001), had lower bone mineral density (p=0.008), and were more likely to have taken osteoporosis medication for less than 6 months (including no medication, p=0.019). The logistic regression analysis showed that the risk of developing new compression fractures was significantly elevated in patients with a low body mass index (odds ratio [OR]=0.69, p=0.02), bone mineral density (OR=0.43, p=0.005), and less than 6 months of osteoporosis medication use (including no medication, OR=1.083, p=0.041). Conclusions: The risk of developing new compression fractures in patients with osteoporotic vertebral compression fractures was associated with body mass index, bone mineral density, and having taken osteoporosis medication for less than 6 months. 연구 계획: 골다공증성 척추 골절 환자에 대해 보조기를 이용하여 보존적으로 치료 후 추시 결과에 대한 후향적 연구이다. 목적: 골다공증성 척추 골절 환자에서 재골절 발생의 위험인자를 알아보고자 한다. 선행 문헌의 요약: 이전에 골다공증성 척추 골절이 진단된 경우, 낮은 골밀도(BMD)는 재골절 위험을 높인다는 연구 결과가 있으며, 척추 성형술이 재골절의 위험 인자인지에 대해서는 논란이 있다. 대상 및 방법: 본원에서 골다공증성 척추 골절 진단받고 최소 1년 이상 추시 가능했던 환자 52명을 대상으로 후향적 연구를 진행하였다. 골다공증성 척추 골절 진단 후 추시에서 일년 이내에 재골절이 있었던 군과 재골절이 발생하지 않은 군간의 연령, 성별, 체질량지수(BMI), 골밀도(BMD), 고혈압, 당뇨병과 같은 기저질환 유무, 후방 신전근 위축정도, 척추 성형술 시행 여부, 골다공증 치료 여부, 시상 지수(sagittal index)를 비교하였다. 두 군 사이에 위에서제시한 요소들을 분석하기 위해 독립 표본 T-test, Chi-square test를 이용하여 검증하였다. 또한, 나이 및 성별을 보정한 후 각 요소들을 분석하기 위해 로지스틱 회귀분석을 하였다. 결과: 평균 연령은 재골절이 발생한 군은 81.3세로, 재골절이 발생하지 않은 군의 74세보다 높았으며, 이는 통계적으로 유의하였다(p=0.011). 재골절이발생한 군은 골밀도(BMD)가 T-score -4.23, 체질량지수(BMI)는 21.05 kg/m2였고, 재골절이 발생하지 않은 군은 골밀도(BMD)가 T-score -3.28, 체질량지수(BMI)는 24.13 kg/m2 였으며, 이는 모두 통계적으로 유의한 차이가 있었다(p=0.008, p=0.001). 또한, 골다공증 약물 치료를 받지 않거나 6개월 미만으로 치료받은 군은 6개월 이상 치료받은 군에 비해 통계적으로 유의하게 재골절이 많았다(p=0.019). 성별과 연령을 보정한 로지스틱 회귀분석에서는 골밀도(BMD) 및 체질량지수(BMI)의 odds ratio 는 각각 0.43, 0.69였고, 이는 모두 통계적으로 유의하였다(p=0.005, p=0.02). 6개월을 기준으로 한 골다공증 약물 치료 여부의 odds ratio 는 1.083 이었고, 이는 통계적으로 유의하였다(p=0.041). 결론: 골다공증성 척추 골절 환자에서 고령, 낮은 골밀도(BMD) 및 체질량지수(BMI), 6개월 미만의 약물 치료는 재골절의 가능성이 높으므로 보다 세심한추시 관찰이 필요하다. 약칭 제목: 척추 재골절 발생의 위험 인자

의무 기록 문서 분류를 위한 자연어 처리에서 최적의 벡터화 방법에 대한 비교 분석

유성림 대한의용생체공학회 2022 의공학회지 Vol.43 No.2

Medical records classification using vectorization techniques plays an important role in natural language processing. The purpose of this study was to investigate proper vectorization techniques for electronic med- ical records classification. Material and methods: 403 electronic medical documents were extracted retrospectively and classified using the cosine similarity calculated by Scikit-learn (Python module for machine learning) in Jupyter Notebook. Vectors for medical documents were produced by three different vectorization techniques (TF-IDF, latent sematic analysis and Word2Vec) and the classification precisions for three vectorization techniques were evaluated. The Kruskal-Wallis test was used to determine if there was a significant difference among three vectorization tech- niques. Results: 403 medical documents were relevant to 41 different diseases and the average number of documents per diagnosis was 9.83 (standard deviation=3.46). The classification precisions for three vectorization techniques were 0.78 (TF-IDF), 0.87 (LSA) and 0.79 (Word2Vec). There was a statistically significant difference among three vec- torization techniques. Conclusions: The results suggest that removing irrelevant information (LSA) is more efficient vectorization technique than modifying weights of vectorization models (TF-IDF, Word2Vec) for medical documents classification.

A Prospective, Multicenter, Observational Study to Assess Distal Radius Fracture Treatment Outcomes Using the Variable-Angle Locking Compression Plate

유성림,이호재,한수홍,김재광 대한수부외과학회 2019 대한수부외과학회지 Vol.24 No.3

Purpose: The 2.4 mm variable-angle locking compression plate (VA-LCP) is designed to treat a variety of distal radius fracture patterns. The purpose of this study was to evaluate the efficacy of the 2.4 mm VA-LCP in treating unstable distal radius fractures.Methods: We recruited eligible patients treated with the device at two Korean sites. In total, we studied 61 enrolled pa-tients. We assessed clinical outcomes and radiographic union, as well as the types of plates and the number of variable-angle locking screws used in the treatment of each fracture type. Radiographic parameters were evaluated at the immedi-ate postoperative period and at 1 year after operation.Results: A total of five complications occurred in 61 patients (8.2%). Radiographic union was achieved in 46/51 (90.2%), 50/51 (98.0%), and 51/51 (100%) patients at 3, 6, and 12 months, respectively. Radiographic parameters evaluated at the immediate postoperative period were 22.4±4.2 degrees (radial inclination), 4.7±0.4 degrees (volar tilt) and 0.8±0.2 de-grees (ulnar variance). Radiographic parameters evaluated at 1 year after operation were 21.3±3.4 degrees (radial inclina-tion), 4.1±0.4 degrees (volar tilt) and 1.2±0.3 degrees (ulnar variance). Wrist range of motion and grip strength measure-ments, as well as self-administered patient questionnaires showed continuous improvements at all follow-up time points. The mean number of screws that were inserted through variable-angle screw guide was 3.2±0.9, while that of screws inserted through fixed-angle screw guide was 3.5±0.9. The majority of patients (85.3%) were treated with a narrow plate.Conclusion: The findings of this study show promising results for the treatment of unstable distal radius fractures using the VA-LCP System.

Restoration of proliferation ability with increased genomic instability from Rad2p-induced mitotic catastrophe in Saccharomyces cerevisiae

유성림,강미선,김호열,이성행,이성근 대한독성 유전단백체 학회 2011 Molecular & cellular toxicology Vol.7 No.3

Yeast RAD2, a counterpart of human XPG,is an essential gene for nucleotide excision repair. Rad2p is an endonuclease that incises the 3’ side of a DNA damaged lesion. However, over-expression of Rad2p provokes cell growth arrest, resulting in mitotic catastrophe as evidenced by formation of enlarged cells and micro-nucleation. Interestingly, the effect of Rad2p on cell growth arrest is not caused by its endonuclease activity, and it has been suggested that Rad2p might be involved in cell cycle regulation. Mitotic catastrophe mainly results in cell death but also functions as a survival mechanism. Using RAD2, we show that some yeast cells growth-arrested by Rad2p-induced mitotic catastrophe regain their ability to proliferate mainly because some Rad2p-induced polyploid cells produce haploid cells with normal cell cycles. Rad2p over-expression also causes increased mutagenesis and the cells with recovered proliferative ability exhibit increased genomic instability, which in turn decreases Rad2p expression. From these results it is inferred that Rad2pinduced polyploid cells undergo increased genetic rearrangement resulting in production of haploid cells.

C-banding 방법에 의한 한국산 청개구리 두 종(Hyla japonica와 Hyla suweonensis)의 핵형 비교분석

유성림,이혜영 한국통합생물학회 1990 동물학회지 Vol.33 No.1

한국산 청개구리 두 종, Hyla japonica와 Hyla suweonensis의 핵형을 C-banding 방법으로 비교분석한 결과 구조적 이질염색질은 두종 모두 주로 동원체 부위에서 관찰되었으나 H. suweonensis의 3번 염색체에서 성별에 따른 이형현상이 나타났으며 이는 ZZ/ZW형의 성염색체로 생각된다. H.suweonensis의 성염색체는 W염색체보다 Z염색체에 더 많은 구조적 이질염색질이 분포하고 있었다. 이러한 현상은 양서류나 다른 척추동물의 성염색첵상의 이질 염색질 분포와는 다른 것으로서 청개구리과의 Gastrotheca ovifera, G. walkeri 와는 같은 현상이었다. The comparative karyological analysis of the Korean treefrogs, Hyla japonica and Hyla suweonensis, were performed by C-banding method. Heteromorphic sex chromosomes, female heterogamety, has been identified in the 3rd chromosomes of H. suweonensis H. suweonensis seem to have sex chromosomes which are Zz/ZW type. The Z chromosomes contain large amount of constitutive heterochromatin, but little heterochromatin is located in the W chromosomes. This is in contrast to all previously known amphibian and most other vertebrate's W or Y chromosomes, except Gastrotheca oui'ern and G. walken (Schmid et al., 1988).

저밀도 Polyethylene에 있어서 Treeing 진전에 관한 고찰

유성림 忠州大學校 1981 한국교통대학교 논문집 Vol.14 No.2

As an organic polymer resin is the material which is highly stablized in electric or chemical, it is widly used a electrical insultating material. But when it is used for a long time, the generation of tree which gradually happen to one of the phenomena of predielectric breakdown take large specifie parts in the cause electric breakdown. So the counter measure for this problem is greatly demanded as it has been compared that the phenomena of the tree in pure. L.D.P.E. with the intial course of generation and advancing course by using L.D.P.E. mixed inorganic fine power Sio₂at aconstant weight rate which posse larger fine dielectric constants than that of the base material and is stablxed the thermal and chemical point of view, this treatise will study how torepress the tree summarized result which is abserved from this experiment is as follows 1. The larger dielectric constants of filler mixed pure L.D.P.E inital generation of tree tand to be expedite in intermixed specimen than pure L.P.D.E 2. in the course of the development of the generated tree, it has been observed that the development of tree was largely suppressed in the intermixed specimen than of the base materical. 3. In the course of the development of the generated tree, it took long time to form the snother branch of three the more branches of tree was gradully formed and it took exponetially longer time to form them.

한국 성인의 흡연기인 사망추이

유성림,김공현,김광기,김정희 한국보건사회학회 2005 보건과 사회과학 Vol.17 No.-

低密度 Polyethylene에 있어서 無機質 微粉을 混入時 混入比에 따른 Treeing진전에 關한 考察

柳盛林 忠州大學校 1982 한국교통대학교 논문집 Vol.15 No.1

As an organic polymer resin is the material which is highly stablized in electric or chemical, it is widly used as electrical insulatating material. But when it is used for a long time, the generation of tree which gradually happen to one of the phenomena of predielectric breakdown take lauge specific parts in the cause electric breakdown. So the counter measure for this problem is greatly demanded as it has been compared that the phenomena of the tree in pure L.D.P.E with the initial course of generation and advancing course by using L.D.P.E mixed power Al?O? at a constant weight rate which posses larger dielectric constants than that of the base material and is stablized the thermal and chemical point of view, this treatise will study how to repress the tree summarized result which is observed from this experiment is as follows: 1. The larger dielectric constants of filler mixed pure L.D.P.E initial generation of tree tend to be expedite in intermixed specimen than pure L.D.P.E. 2. In the course of the development of the generated tree, it has been observed that the development of tree was largely suppressed in the intermixed specimen than pure L.D.P.E.

M.O.M 구조의 전기전도에 관한 고찰

柳盛林 忠州大學校 1995 한국교통대학교 논문집 Vol.30 No.1

This paper investigates the electrical conduction mechanisms in M.O.M structure. The behaviour of J-E and J-T characteristics shows that in M.O.M diode with oxide thickness less than 100Å, the dominant conduction process is shottky emission. In M.O.M diode of thickness 500Å, space-charge-limited current is observed, and it is confirmed by the fast that J-V characteristics of the samples are thickness dependent.

金屬-絶緣體-金屬 다이오드의 傳導 特性에 關한 考察

柳盛林 忠州大學校 1996 한국교통대학교 논문집 Vol.31 No.1

In this article electicasl conduction mechanisms are inverstigated in M(metal)-I(insulator)-M(metal) (Mg-MgO-Mg) diodes. The behaviour of J-E and J-T characteristics shows that the dominant conduction process in M.I.M diode with oxide thickness 300Å, is Schottky emission.