철근콘크리트 띠철근 기둥의 구속효과

왕성근(Wang, Sung Keun),한범석(Han, Beom Seok),이희수(Lee,Hee Su),신성우(Shin, Sung Woo),반병열(Bahn, Byong Youl) 한국콘크리트학회 2001 한국콘크리트학회 학술대회 논문집 Vol.2001 No.11

한국인 조현병 환자와 도파민 D2 수용체 유전자 다형성과의 관련연구

김태성,차승민,왕성근,김정란,이영호,최혜인,지익성,Kim, Tae-Sung,Cha, Seung-Min,Wang, Seong-Keun,Kim, Jeong-Lan,Lee, Young-Ho,Choi, Hye-In,Chee, Ik-Seung 대한생물정신의학회 2012 생물정신의학 Vol.19 No.1

Objectives : This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia. Methods : TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls. Results : There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls. Conclusions : These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.

한국인에서 연령 증가에 따른 분노와 공격성의 변화

박재상(Jae-Sang Park),임채성(Chae-Sung Im),김태성(Tae-Sung Kim),왕성근(Seong-Keun Wang),지익성(Ik-Seung Chee),김정란(Jeong-Lan Kim) 대한노인정신의학회 2010 노인정신의학 Vol.14 No.2

Objectives : This study was to investigate the trends in anger and aggression with aging in Korean population aged from twenties to eighties. Methods : Two hundreds ninety-five subjects included, ranged 22 to 92 years old. All subject participate in a clinical interview with psychiatrists who use the MINI (Mini international Neuropsychiatric Interview) to diagnosis psychiatric disorders, and were not any psychiatric disorders. Results : In elderly group, the scores of Trait anger, Anger expression, and totol of STAXI were higher than adult group, where as the scores of State anger of STAXI, Hostility of AQ, and Disturbances, Embarrassing, Unpleasant circumstances, and total of RI were higher in adult group. Trait anger and Anger expression were shown trends to increase with age. On the other hands, State anger, Hostility, and Reaction to external stimuli were shown trends to decrease with age. Conclusion : The reaction to anger situation and aggression decrease with age, although anger increase with age. Various factor, such as defense mechanism may affect on aggressive expression and response. There will be needed to investigate associated factors between anger and aggression.

노년기 정신장애 환자의 기본적 일상생활 기능에 영향을 미치는 우울 및 인지 요인에 대한 예비연구

박한결(Han-Kyul Park),왕성근(Seong-Keun Wang),이종범(Jong-Bum Lee),김진성(Jin-Sung Kim),배대석(Dai-Seok Bai),구본훈(Bon-Hoon Koo) 대한생물치료정신의학회 2010 생물치료정신의학 Vol.16 No.1

노년기 정신장애 환자들의 우울증상과 인지기능장애의 특성이 일상생활 기능에 미치는 영향을 알아보고자 114명을 대상으로 노인 우울증 집단, 알쯔하이머형 치매 집단, 신경증적 장애 집단으로 구분하여 서울신경심리검사를 시행한 결과 다음과 같은 결론을 얻었다. 일상생활 기능에 영향을 미치는 우울증상과 인지기능 장애의 구체적 요인을 살펴보면, 노인 우울증 집단에서는 인지기능 요인보다는 우울증상 요인, 특히 초조감이 일상생활 기능에 영향을 미치는 것으로 나타났다. 알쯔하이머형 치매 집단의 경우 일상생활 기능에 영향을 미치는 인지기능 요인은 전두엽/실행기능과 연관된 범주 또는 의미 유창성이었고, 우울증상 요인은 사회적 철수 경향과 불행감이었다. 신경증적 장애 집단은 결혼 상태와 질환의 이환기간, 그리고 우울증상 중 초조감이 일상생활 기능에 영향을 주는 것으로 나타났다. 따라서 노인성 정신장애 환자에서 우울증상과 인지기능장애가 일상생활에 영향을 미치는 정도나 특정요인은 각 질환마다 다양하며 이에 따른 개입방법 및 향후 대책이 필요할 것으로 생각된다. Objectives:The purpose of this study is to investigate specific factors of depression and cognitive dysfunction that affect on basic activities of daily living among psychiatric disorders in elderly patients. Methods:Groups with geriatric depression, Alzheimer’s disease and neurotic disorders in elderly patients were selected, and were performed Seoul Neuropsychological Screening Battery(SNSB). Results:In group with geriatric depression, agitation can affect on activities of daily living rather than factors of cognitive dysfunction. Factor of cognitive dysfunction that affect on activities of daily living in group with Alzheime'r’s disease is category/semantic fluency relation to frontal/executive function, and factors of depression that affect on activities of daily living in group with Alzheimer’s disease are social withdrawal tendency and feeling of unhappiness. And, factor that affect on activities of daily living in group with neurotic disorders in elderly patients is agitation rather than factors of cognitive dysfunction. Conclusion:The degrees and specific factors of depression and cognitive dysfunction that affect on basic activities of daily living among psychiatric disorders in elderly patients are variable in each specific illness. Clinicians should consider these kind of specific factors in the treatment of elderly patients.

T102C Polymorphism of the 5-HT<SUB>2A</SUB> Receptor Gene is not Associated with Homicide in Male Schizophrenics

Ik-Seung Chee(지익성),Seung-Keun Wang(왕성근),Sun-Woo Lee(이선우),Jeong-Lan Kim(김정란),Young-Ho Lee(이영호),Sang-Sup Choi(최상섭),Chung-Suk Lee(이충숙) 대한생물치료정신의학회 2007 생물치료정신의학 Vol.13 No.2

목적:세로토닌체계의 변화가 정신분열병이나 폭력행동과 관련이 있다고 알려져 있다. 저자 등은 5-HT2A 수용체 유전자 다형성(T102C)이 살인을 범한 남성 정신분열병과 관련이 있는지 알아보기 위하여 본 연구를 시행하였다. 방법:살인을 범한 정신분열병 환자 105명, 비폭력 정신분열병 환자 102명, 정상 대조군 104명을 대상으로 중합효소 연쇄반응을 이용하여 5-HT<SUB>2A</SUB> 수용체 유전자 다형성(T102C)의 유전자형과 대립유전자의 빈도를 비교하였다. 모든 대상은 한국인 남자였다. 결과:살인을 범한 정신분열병군, 비폭력 정신분열병군, 정상대조군을 비교한 결과 세군간에 유전자형(χ²=8.090, df=4, p=0.088)이나 대립유전자(χ²=2.880, df=2, p=0.237)에서 통계적인 차이가 없었다. 또한 살인을 범한 정신분열병군과 비폭력 정신분열병군, 살인을 범한 정신분열병군과 정상 대조군, 그리고 비폭력 정신분열병군과 정상 대조군을 각각 비교하였을 때도 유전자형과 대립유전자에서 통계적인 차이가 없었다. 결론:이러한 결과는 5-HT<SUB>2A</SUB> 수용체 유전자 다형성(T102C)이 남성 정신분열병환자의 살인행동과는 관련이 없음을 제시한다. 향후 살인을 범한 여성정신분열병환자와 살인을 범한 일반 범죄인을 포함한 연구가 필요할 것으로 사료된다.

치료감호중인 조현병 환자에서 성격 평가 질문지를 이용한 정신병질적 성격평가

이미지(Mi-Ji Lee),홍성곤(Sung-Gon Hong),이재우(Jae-Woo Lee),권지현(JeeHyun Kwon),왕성근(Seung-Keun Wang),지익성(Ik-Seung Chee) 대한생물치료정신의학회 2012 생물치료정신의학 Vol.18 No.2

Objectives:This study was conducted to evaluate the validity of the Antisocial Features(ANT) scale of the Personality Assessment Inventory(PAI) with Psychopathic Personality Inventory-Revised(PPI-R) total score to assess psychopathy in Korean criminal offenders with schizophrenia. Methods:The subjects included 177 inpatients with schizophrenia who committed crimes. All subjects filled out PPI-R and PAI. The statistics are carried out by SPSS version 17.0. Results:The result shows that ANT scores are correlated highly with the PPI-R total score(r=0.56). Of the three subscales of ANT ; Egocentricity(ANT-E), Stimulus Seeking(ANT-S), Antisocial Behavior(ANT-A), ANT-E(r=0.53) and ANT-S(r=0.56) subscales showed strong correlations with PPI-R total score, and ANT-A (r=0.38) subscale was moderately associated with PPI-R total score. Among the 8 subscales of PPI-R, Rebellious Nonconformity(RN), Machiavellian Egocentricity(ME), Blame Externalization(BE) subscales were relatively strongly correlated with PAI scales ; ANT, ANT-E, and ANT-S. Between 2 factors of PPI-R, Self-Centered Impulsivity(SCI) factor showed relatively powerful association with ANT scale of PAI. ROC curve for ANT with PPI-R diagnoses of psychopathy tells that ANT scale dose not seem to make categorical prediction of psychopathy on PPI-R. Conclusions:ANT scale of PAI tapped primarily behavioral symptoms of psychopathy rather than interpersonal and affective symptoms. Despite of strong correlation between PPI-R total score and ANT score of PAI, the result of ROC curve suggests that it might be better to use ANT score as dimensional measure of psychopathy rather than categorical, in Korean criminal offenders with schizophrenia.

한국어판 Modified Mini-Mental State (3MS-K) Examination의 신뢰도와 타당도

김민구(Min-Goo Kim),이선우(Sun-Woo Lee),왕성근(Sung-Keun Wang),지익성(Ik-Sung Chee) 대한생물치료정신의학회 2005 생물치료정신의학 Vol.11 No.2

Objectives: The purpose of this study was to test the validity and reliability of the Korean version of Modified Mini-Mental State(3MS-K) examination. Methods: The subjects were total 76 patients in the psychiatric hospital and day hospital. All subjects were examined one Cognitive Examination of Cambridge Examination for the Mental Disorder of the Elderly(CAMCOG) by one rater, and also were examined two 3MS-K examinations and two Mini Mental State Examination(MMSE)s by two raters. Results: For reliability of 3MS-K, Cronbach alpha was 0.966, Pearson correlation coefficients for inter-rater reliability was 0.996(p<0.001). For item-total correlation coefficients in two raters were ranged between r=0.399 to r=0.921. Pearson correlation coefficients for the total scores between 3MS-K and CAMCOG in two raters, were 0.972 and 0.979 respectively. The cut-off scores of 71 had a sensitivity of 92% and a specificity of 93%, and the area under the Receiver Operating Characteristics(ROC) curve was 0.921. Conclusion: The results revealed that 3MS-K could be a reliable and valid tool for cognitive assesment. However, further study is in need to investigate it's clinical usefulness.

Methylphenidate에 의해서 유발된 주의력결핍-과잉행동장애 환자의 수면장애에 대한 Mirtazapine의 치료효과 : 증례 및 고찰

임명호(Myung Ho Lim),이우철(Woo Chul Lee),이상구(Sang Koo Lee),이창민(Chang Min Lee),김현우(Hyun Woo Kim),왕성근(Seong-Keun Wang) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.2

주의력결핍-과잉행동장애(Attention Deficit Hyperactivity Disorder)는 소아청소년시기에 5~10%의 유병율을 갖고 있는 매우 흔한 질환이다. 주의력결핍-과잉 행동장애에서 임상적으로 가장 많이 사용되고 있는 methylphenidate는 과잉행동 및 주의력 개선에 70~85% 정도의 높은 증상 개선율을 갖고 있지만 반면에 수면장애, 식욕부진, 두통 등의 부작용을 호소하는 아동으로 인하여 임상적으로 어려움을 겪기도 한다. 한편 mirtazapine은 노르아드레날린과 세로토닌의 신경전달을 함께 강화하는 새로운 항우울제이며, 또한 mirtazapine은 히스타민 수용체와 아드레날린성 및 콜린성 수용체를 길항함으로써 우울장애에 함께 수반된 수면장애에도 효과가 있었음을 보고하는 외국사례가 있었다. 본 저자는 주의력결핍-과잉행동장애로 진단받은 6세 아동에서 methylphenidate 투여를 시작한 이후 이차적으로 발생한 수면장애에 대해서 항우울제인 mirtazapine을 투여하여 수면다원 검사상 서파수면의 증가 및 REM수면의 감소 등 객관적인 수면장애 증상 개선을 보였기에 이를 보고하고 문헌을 함께 고찰하고자 한다. Objectives:This case presents a 6 year-old-boy diagnosed with ADHD. The patient was hospitalized under the chief complaint of hyperactivity behavior and distracted inattention. A secondary sleep disorder was found after 10㎎ qd of methylphenidate was started, administering mirtazapine revealed improvement of sleep disorder. Case:On July 9 2005, the child was hit by a small vehicle on the road between his apartment and a shopping mall. After this accident a child was referred for treatment of hyperactivity and distractibility. After adding 10mg qd of methylphenidate IR, his PSQI global score was 9 and his ISI total score was 15 which are consistent with moderate stage of insomnia. Polysomnography was performed to detect the objective sleep disorder. As a result of the increase of REM sleep and the decrease of REM latent period further investigation was carried out. From the 16th day of hospitalization 15㎎ of mirtazapine was given hs for a week. Soon after starting mirtazapine the child fell a sleep without whining time and his shouting were much improved. On a 7th day of mirtazapine administration, PSQI global score of 2 and ISI total score of 3 was noted which represented a significant improvement. Polysomnography was reperformed on the 10th day as a result the delay of REM latent period and the decrease of REM sleep as a normal range, The normalization of REM sleep rhythm and the increase of slow wave were objectively improved. Discussion:When methylphenidate is used in the treatment for ADHD, Clinical course shows a sleep disorder in 29~64% of ADHD subjects. mirtazapine(Remeron), the antidepressant, has an antagonistic effect for 5HT2a receptor and is recently used for its effect in the improvement of sleep disorder. The Author hereby report that mirtazapine objectively improves sleeping disorders which often results from giving methylphenidate in ADHD.