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향에 대한 자율신경계 반응 및 선호도 -청년층과 노년층의 연령차 비교-
오혜영 ( H. Y. Oh ),민병찬 ( B. C. Min ),이선영 ( S. Y. Lee ),남경돈 ( K. D. Nam ),강인형 ( I. H. Kang ),성은정 ( E. J. Sung ),김철중 ( C. J. Kim ) 한국감성과학회 2001 추계학술대회 Vol.2001 No.-
본 연구에서는 향에 대한 생리적 반응과 선호도가 노년층과 청년층에서 어떠한 차이가 있는지 살펴보고자 하였다. 20대 및 60대 피험자에게 100%의 Basil oil, Jasmin oil, Lavender oil, Lemon il, Ylangylang oil을 제시하여 자율신경계의 반응인 심전도의 RR간격과 GSR을 측정·분석하였으며, 선호도 평가를 하여 자율신경계의 반응과의 상관성을 검토하였다. 20대는 Lemon 향에서 RR 간격 및 GSR의 반응이 안정되게 나타났으며, 선호도 평가에서도 Lemon 을 가장 선호도가 높게 평가하는 것을 볼 수 있었다. 60대는 Lavender에서 RR 간격이 증가하고 GSR이 감소하여 안정된 반응을 보였고, Lavender에 대한 선호도 또한 높게 평가하여 60대는 다른 향보다 Lavender를 좋은 향으로 평가함을 알 수 있었다.
동적 시뮬레이터에서 Simulator Sickness와 자율신경계 반응
전효정 ( H. J. Jeon ),민병찬 ( B. C. Min ),김유나 ( Y. N. Kim ),전광진 ( K. J. Jeon ),오혜영 ( H. Y. Oh ),성은정 ( E. J. Sung ),정순철 ( S. C. Chung ),김철중 ( C. J. Kim ) 한국감성과학회 2001 춘계학술대회 Vol.2001 No.-
본 연구는 시뮬레이터 실험에서 필수적으로 발생하는 Simulator Sickness(SS)를 평가하기 위하여 동적 시뮬레이터에서 일정한 속도(60km/h)로 1시간 주행했을 때 Simulator Sickness Questionnaire(SSQ)를 이용하여 주관적 Sickness를 평가하고 생리적 반응으로 심박 변동량(HRV)과 피부온도 및 피부저항을 측정하여 성별, Simulator 수준에 따라 비교 분석하였다. 분석 결과 동적 시뮬레이터에서 주행시 주관적인 Simulator Sickness는 안정에 비해 시간이 지남에 따라 45분까지 선형적으로 증가하여UT고, 여자와 sick군이 남자와 nonsick군에 비해 더 높았으며 sickness 수준간에서는 유의성이 나타났지만 남녀간의 유의한 차이는 없었다. 생리적 반응은 시간에 따른 변화는 없었으나 안정에 비해 R-R 간격의 감소, (LF+MF)/total 및 (LF+MF)/HF의 증가로부터 교감 신경이 활성화되었으며 피부온도의 감소와 피부저항의 증가로부터 긴장도가 커짐을 알 수 있었다. 주행 50분 이후는 HF/total가 감소하여 부교감 신경의 작용이 저하되는 것으로 나타났다.. 성별, sickness수준에 따라서는 남녀간에는 부분적으로 유의한 차이가 있었고 평균 R-R 간격에서만 sick군이 nonsick군보다 유의하게 낮았다.
Balb/c 마우스에서 유기인계 농약인 Pirimiphos-methyl 및 Methidathion의 면역독성
엄준호(Juno H. Eom),정승태(Seung-Tae Chung),박재현(Jae Hyun Park),길정현(Jung Hyun Kil),이종권(Jong Kwon Lee),오혜영(Hye Young Oh),김형수(Hyung Soo Kim) 한국독성학회 2004 Toxicological Research Vol.20 No.4
Primiphos-methyl and methidathion as organophosphorus (OP) pesticides were tested for their immunotoxic effects on Balb/c mice. Three dose levels of primiphos-methyl (10, 60, or 120 mg/kg/day) and methidathion (0.5, 2.5 or 5.0 mg/kg/day) were administered orally in the mice for 4 weeks. After, changes in body weight gain, relative weight of spleen and thymus, viable splenic cell numbers, surface marker on immune cell, and proliferation activity were investigated. Results showed that neither Pirimiphos-methyl nor methidathion dosages changed significantly body weight, relative thymus and spleen weight, and thymus and spleen cellularities of the mice, but high dose treatment (120 mg/kg) of pirimiphos-methyl significantly decreased relative spleen weight and spleen cellularity of the mice. No alterations were observed in changes of LPS-proliferation response of splenocytes by exposure to any dose of pirimiphos-methyl and methidathion. However, pirimiphos-methyl dosages reduced ConA-proliferation response of splenocytes and both methidathion and pirimiphos-methyl decreased the ability of antibody production to SRBC. The results indicate that 28 days exposure to the high dose of pirimiphos-methyl suppress the function of splenic T and B cell function, and methidathion reduce the immune responsibility of B cell in mice without the changes in lymphoid organ weight or viability of splenocytes. Pirimiphos-methyl is more immunotoxic than methidathion although this has higher general toxicity than that.
조영주,엄준호,길정현,박재현,이종권,오혜영,박귀례,김형수,Cho, Young-Joo,Eom , Juno H.,Gil , Jung-Hyun,Park , Jae-Hyun,Lee , Jong-Kwon,Oh , Hye-Young,Park , Kui-Lea,Kim , Hyung-Soo 대한약학회 2004 약학회지 Vol.48 No.6
Interleukin-2 (IL-2), a glycoprotein mainly secreted by CD4+ T helper Iymphocytes, has been developed to use recombinant cytokine to augment the immune response against cancer since IL-2 not only stimulates T Iymphocytes but also enhances natural killer (NK) cell activity. In order to evaluate the immunological safety of recombinant mouse IL-2 (rmIL-2) in cancer therapy, renal cell carcinoma was established in the flank by s.c. injection of renca cell line. Tumor-bearing BALB/c mice were treated with I.p. injections with $2{\times}10^5$ Lu rmIL-2. Even though the tumor size was diminished, there were not significant recovery of body and relative lymphoid organ weights including thymic atrophy in rmIL-2 immunotherapy. Distribution ratios of T cell subsets in thymus were analysed using flow cytometry. Without regard to dosage of rmIL-2, the ratio of CD3+CD4-CD8- T cells was increased in accordance with survival of solid tumor but that of CD4+CD8+ T cells was decreased dramatically. Emergence of autoantibodies (ANA, anti-dsDNA, and anti-histone) in blood was measured after rmIL-2 treatment. The results showed that the levels of ANA and anti-dsDNA did not significantly changed, but the level of anti-histone was increased significantly owing to rmIL-2 therapy. These results indicate rmIL-2 immunotherapy is to induce the autoimmune potential, and the anti-histone measurement as a biomarker of autoimmunity is useful in cancer immunotherapy.
BrdU ELISA를 이용한 국소 림프절 시험법의 비방사선법 연구
이종권(Jong Kwon Lee),박재현(Jae Hyun Park),박승희(Seung Hee Park),김형수(Hyung Soo Kim),정승태(Seung Tae Chung),엄준호(Juno H. Eom),윤소미(So Mi Yun),장은정(Eun Jung Jang),최광식(Kwang Sik Choi),오혜영(Hye Young Oh) 한국독성학회 2003 Toxicological Research Vol.19 No.2
Allergic contact dermatitis may be caused by a wide variety of chemicals. A murine local lymph node assay (LLNA) has been developed as an alternative to guinea pig models for assessing the contact sensitization potential of chemical. However, there is a need to develop a nonradioisotopic endpoint for the LLNA, because of the radioisotopic method's requiring the use of special<br/> facilities. In this study, we investigated the development of a non-radioisotopic endpoint for LLNA using ELISA (enzyme-linked immunosorbent assay). Female Balb/c mice were treated by the topical application on the dorsum of both ears with four different strong sensitizers, 2,4-dinitrochlorobenzene (DNCB), oxazolone (OXZ), toluene diisocyanate (TDI), and trimellitic anhydride (TMA), and a strong irritant, sodium lauryl sulfate (SLS), once daily for three consecutive days. The proliferation of cells in the auricular lymph node was analyzed by means of the labelling index (LI) of bromodeoxyuridine (BrdU) incorporation into cells. The weights of the lymph nodes in the mice treated with allergens, DNCB, OXZ, TDI and TMA were increased compared to the vehicle control. The stimulation index (SI) of mice treated with DNCB, OXZ, TDI, and TMA was over three-fold increase compared to the vehicle control. However, the SI of mice exposed to SLS was not significantly increased compared to the vehicle control, while the lymph node weight of SLS was significantly increased. These results suggest that the LLNA modified endpoint using ELISA based on BrdU incorporation could provide a useful method of screening for irritants and allergens.