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변종호,이형,김민경,김현아 대한신경과학회 2018 대한신경과학회지 Vol.36 No.2
Immunoglobulin G4 (IgG4)-related disease is a recently recognized entity characterized by abundant tissue infiltration by IgG4-positive plasma cells and high serum levels of IgG4. IgG4 disease can also affect the lacrimal glands and periocular tissues and usually manifest painless eyelid or periocular tissue swelling. However, IgG4 related ophthalmic disease rarely cause diplopia. We report a case of diplopia IgG4 related ophthalmic disease presenting as diplopia and headache.
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卞宗鎬,嚴龍大,柳泓善,辛民敎 한국전통의학연구소 1999 한국전통의학지 Vol.9 No.2
We studied biblographically on the origin of Zitanxiang which is commonly used at Oriental Traditional and Herbal Drugs Clinic. Results are as follows. We can find out that ; 1. In China, Pterocarpus indicus Wild. and Pterocapus santalinus L. which are duramen of woody parts of the plants of Leguminosae are used as Zitanxiang medicinal stuff. 2. In Korea, Sabina chinensis(L) Antoin (= Juniperus chinensis L.) which is the woody parts of Chinese cypress which is evergreen arbor and one of the plants of Cupressaceae is used as Zitanxiang medicinal stuff. Therefor, it is thought that comparison research have to be studied on these different Zitanxiang medicinal stuffs on the basis of efficacy.
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변종호 ( Jong Ho Byun ),강영성 ( Young Sung Kang ),김성수 ( Sung Soo Kim ),김대한 ( Dae Han Kim ),황대룡 ( Dae Ryong Hwang ),신민교 ( Min Kyo Shin ),송호준 ( Ho Joon Song ) 대한본초학회 2003 대한본초학회지 Vol.18 No.2
Objective : To evaluate effect of allergy by Tripterygiwn regelii (TR), the biochemical changes associated with allergy were measured in BALF. serum splenocyte and lung of mice. Methods : After induction of allergic inflammation asthma by treatment of ovalbumine, water extracts from stem and leaf (SL) or flower (FL) of TR were taken orally for five successive days on mice, respectively. Result : In the total cell of BALF. the SL-TR extract (lCKhwk, h.w)-treated group was significantly reduced compared to control level and the reduction of eosinophil showed significantly at concentraton of 360 and loo0 dks, b.w. On the other hand, substantial decrease in IgE antibody formation was significantly observed by administration with SL-TR extract, whereas IgGZa was not affected. IgCl antibody formation appeared to be decreased inserum from SL-TR treated mice(l000 mg/kg, b.w). The content of IL-4 exhibited physiological role in splenocyte and lung was significantly reduced in the examined group compared to that of control after treatment of SL-TR extract(l@X/kg, b.w). In the case of IL-5, however, it was significantly reduced by FL-TR extract. In addition, IL-5 content in splenocyte was significantly reduced at concentration of 360 and loo0 d k g . b.w. by SL-TR dose, respxtively, and that of lung was significantly reduced dose-dewndently(l20, 360 and 1000mp/kg, b.w). Cnnclusion : It could be conduded that TripteTygiwn regelii showed beneficial effect on the allergic asthma and especially, its leaf and stem is more effective than flower.
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김근태,변종호,조용원 대한신경과학회 2018 대한신경과학회지 Vol.36 No.2
The efficacy and the adverse effects of intravenous iron formulas have been well established. However, there are few reports of anaphylaxis of ferric carboxymaltose (FCM). A man received intravenous FCM for the treatment of restless legs syndrome. The FCM gave rise to angioedema, urticaria, chest tightness, sinus tachycardia, and hypotension. In the end, epinephrine and dexamethasone resolved the symptoms. The findings were consistent with anaphylactic hypersensitivity reaction from FCM. We need to be careful when we administer FCM in clinics.
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류명환,엄용대,변종호,조훈,양은영,강길웅,신민교,백승화,Ryu, Myeng-Hwan,Aeam, Yong-Dea,Byun, Jong-Ho,Cho, Hoon,Yang, Eun-Yeong,Kang, Kil-Ung,Shin, Min-Kyo,Baek, Seung-Hwa 한국생약학회 2000 생약학회지 Vol.31 No.1
This study was carried out to evaluate cytotoxic effects of Ajuga multiflora Bunge extracts on murine leukemia tumor $(P388D_1)$ cell lines. Disruptions in cell organelles were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT) assay. The comparison of $IC_{50}$ values of Ajuga multiflora Bunge extracts in L1210 and $P388D_1$ cell lines showed that their susceptibility to these extracts decreased in the following order: Adriamycin>methanol extract>chloroform extract>ethyl acetate extract>hexane extract>water extract by the MTT assay. In order to develop an antimicrobial agent, dried Ajuga multiflora Bunge was extracted with several solvents, and then antimicrobial activity was investigated. The minimal inhibitory concentration (MIC) of the extract against microorganisms were also examined. Antimicrobial activities of amocla and ketoconazole as references were compared to those of extracts of $H_2O$, n-hexane, chloroform, ethyl acetate and methanol. The antimicrobial activity of all extracts from the sample had growth inhibition activity against gram-negative bacteria, gram-positive bacteria and fungi $(MIC>200\;{\mu}g/ml)$. These results suggest that the methanol soluble extract of Ajuga multiflora Bunge may be a valuable choice for the studies on the treatment of murine leukemia tumor cell lines.
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