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1990년대 및 2000년대 진단적 복수천자를 받은 환자에서 복수의 원인분석
심재준 ( Sim Jae Jun ),노태준 ( No Tae Jun ),김병호 ( Kim Byeong Ho ),김남훈 ( Kim Nam Hun ),임근우 ( Im Geun U ),정용희 ( Jeong Yong Hui ),한요셉 ( Han Yo Seb ),동석호 ( Dong Seog Ho ),김효종 ( Kim Hyo Jong ),장영운 ( Jang Yeong 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 국내에서 복수 환자의 원인분석에 대한 보고는 없었다. 저자들은 최근 진단적 복수천자를 시행 받은 환자에서 원인질환과 검사소견을 분석하였다. <대상 및 방법> 복수로 경희의료원에 입원하여 복수천자검사를 받았던 1996년도 77명과 2001년도 147명의 환자를 대상으로 복수 원인을 알아보았고, 원인에 따른 임상양상과 검사소견을 조사하였다. <결과> 전체 환자(n=224, 남:여=143:81)의 평균 연령은 54±14세로 1996년과 2001년 연
심재준(Jae Jun Sim),정우진(Woo Jin Jeong),양현석(Hyeon Seok Yang),한복규(Bok Gyu Han),조용채(Yong Chae Cho),이호경(Ho Gyeong Lee),문영식(Young Shik Moon) 대한전자공학회 2018 대한전자공학회 학술대회 Vol.2018 No.11
We propose an indoor haze removal method using MSCNN and cGAN. The structure of the network consists of multi-scale CNN and cGAN for photo realistic result. Our method outputs the haze removal image immediately, unlike the existing methods of estimating the depth map. Our method has a quantitative evaluation of 22.6879 in PSNR and 0.8872 in SSIM, which is higher than state of the art by 1.342 in PSNR and 0.0116 in SSIM. It also has good results in qualitative evaluation.
Convolutional encoder-decoder를 이용한 인쇄 회로 기판의 표면 실장 소자 분류
심재준(Jae Jun Sim),조성민(Sung Min Cho),장권규(Kwon Kyu Jang),문영식(Young Shik Moon) 대한전자공학회 2017 대한전자공학회 학술대회 Vol.2017 No.6
We propose a method for a SMD segmentation by using a convolutional encoder-decoder. Our method distinguishs an information and a location of a SMD on the PCB from an optical image. We use the encoder-decoder architecture. The encoding network is based on VGG net. The decoding network is composed of a convolutional transpose and a convolution layer. The proposed method achieves 98.8%, 96.8% precisions about the register and the capacitor.
심재준(Jae Jun Sim),정우진(Woo Jin Jung),양현석(Hyeon Seok Yang),한복규(Bok Gyu Han),조용채(Yong Chae Cho),문영식(Young Shik Moon) 대한전자공학회 2018 전자공학회논문지 Vol.55 No.9
최근 신경망이 활발히 연구되어 다양한 분야에 적용되고 있으며, 영상처리의 다양한 분야(초해상도 복원, 영상 분류, 영상분할 등등)에서도 신경망을 도입하여 이전보다 나은 성과를 내고 있다. 본 논문에서는 의료영상에 깊은 신경망을 활용하여 세포핵 영역을 분할하는 기법을 제안한다. 본 논문에서 제안하는 네트워크 구조는 수용영역이 서로 다른 세 개의 네트워크를 병렬 처리하는 병렬 네트워크와 분류 네트워크로 이루어져 있다. 네트워크의 입력은 원본 영상을 전처리한 영상과 가이드 영상을 사용한다. 제안하는 방법은 풀링을 제거한 Deeplab-v1보다 mIOU가 4.61% 높고, 1024×1024 크기 영상에서 1.92배 빠르다. Recently, neural networks have been actively studied and applied in various fields. In the various fields of image processing (super resolution restoration, image classification, image segmentation, etc.), neural networks have been introduced to achieve better results than before. In this paper, we propose a technique to segment the nuclei region using deep neural network for medical images. The network structure used in this paper consists of three networks with different receptive field and a classification network. The input of the network is the pre - processed image and the guide image of the original image. The proposed method is 4.61% higher in mIOU than Deeplab-v1 with pooling removed and 1.92 times faster in 1024×1024 size image.
IgA 신증 환자들에서 스테로이드와 안지오텐신 2 수용체 차단제의 병합 투여 효과
이상훈 ( Lee Sang Hun ),심재준 ( Sim Jae Jun ),이상호 ( Lee Sang Ho ),이태원 ( Lee Tae Won ),김명재 ( Kim Myeong Jae ),양문호 ( Yang Mun Ho ),임천규 ( Im Cheon Gyu ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.5
배 경 : IgA 신증 환자들에서 고용량의 스테로이드 치료가 단백뇨 감소 및 신보호 효과가 있으며, 안지오텐신 Ⅱ 수용체 차단제 (ARB) 투여도 도움이 된다는 보고들이 있다. IgA 신증 환자들에서 이 두 가지 약제를 병합 투여함으로써 단백뇨 및 신기능에 부가적 효과가 있는지를 전향적 연구로 알아보고자 하였다. 방 법 : 신생검으로 IgA 신증을 진단 받고 1일 1 g 이상의 단백뇨와 혈청 크레아티닌이 2.0 ㎎/dL 이하인 42명의 환자를 무작위로 스테로이드와 ARB의 병합 투여군과 ARB 단독 투여군 으로 나누어 추적 관찰하였다. 결 과 : 병합 투여군은 18명, ARB 단독 투여군은 20명이 추적 관찰되었으며 추적기간은 각각 15.4±3.5 및 19.8±7.4개월이었다. 24시간 단백뇨량은 병합 투여군이 치료 전 4.67±5.33 g에서 0.78±0.99 g으로, ARB 단독 투여군이 4.31±2.85 g에서 1.38±1.09 g으로 유의하게 감소하였다. 추적 후 완전 관해율은 병합 투여가 44%로서 ARB 단독 투여의 10%에 비해 유의하게 높았다. 혈청 크레아티닌은 두 군 모두 치료 시작 전과 후에 통계학적으로 유의한 변화는 없었으며 (병합 투여군: 1.33±0.38 ㎎/dL->1.33±0.46 ㎎/dL, ARB 단독 투여군 : 1.08±0.39 ㎎/dL->1.32±0.79 ㎎/dL), 두 군 사이에도 차이가 없었다. 신기능 악화 증례도 병합 투여군이 1명 (5%), ARB 단독 투여군이 5명 (25%)이었다. 부작용으로는 병합 투여군에서 1예의 당뇨병과 1예의 당불내성이 발생하였다. 결 론 : 두 치료법 모두 단백뇨 감소에 효과적이었으며, 스테로이드와 ARB의 병합요법에서 완전 관해율이 더 높았다. 두 치료법의 신기능 보존 효과의 여부는 더 장기적인 추적 관찰이 필요하다고 생각된다. Background : It has been reported that prednisolone (PDL) therapy favorably influences proteinuria and renal function in the patients with IgAN in whom ARB as well as ACE inhibitor has an anti-proteinuric effect. Therefore, we did a controlled prospective trial to test the effect of treatment with PDI, (daily high- dose for 6 months) and ARB in proteinuric adult patients with IgAN. Methods : Forty-two patients with proteinuria ≥1.0 g/day and serum Cr ≤2.0 mg/dL were randomized to treatment with PDL and ARB and to that with ARB alone. Results : The follow-up period lasted 15.4±3.5 months in combination group (n=18) and 19.8±7.4 months in ARB group (n=20). Proteinuria was significantly reduced in the both groups (ARB group: from 4.31±2.85 g to 1.38±1.09 g vs. combination group: from 4.67±5.33g to 0.78±0.99 g). The rate of complete remission was 10% in ARB group and 44% in combination group at the final follow-up (p<0.05). There were no differences of mean serum Cr between groups before and after treatment. The number of patient with aggravation in renal function was five (25%) in ARB group and one (5%) in combination group. Conclusion : This study shows that the urinary protein excretion was effectively reduced by both groups and the rate of complete remission was higher in combination group than in ARB group. Long-term follow-up may be helpful to define the effect on the renal function in IgAN patients.
무증상 한국인에서 Helicobacter Pylori 감염의 위험인자
김나영(Na Young Kim),김재규(Jae Gyu Kim),김진호(Jin Ho Kim),김학양(Hak Yang Kim),김상우(Sang Woo Kim),김재준(Jae Jun Kim),노임환(Im Hwan Roe),심재건(Jae Geon Sim),안형식(Hyeong Sik Ahn),윤병철(Byung Chul Yoon),이상우(Sang Woo Lee),이용 대한내과학회 2000 대한내과학회지 Vol.59 No.4
Background : The prevalence of Helicobacter pylori (H. pylori) infection varies between countries and between social classes. The aim of this study was to identify risk factors for with Helicobacter pylori infection in asymptomatic Korean population. Methods : Sera were collected from 2,687 females and 3,049 males (mean age, 29.1 y; range, 1 m-79 y) in Korea from Mar 1998 through Oct 1998. All asymptomatic subjects completed assessment questionnaires. An enzyme-linked immunosorbent assay was performed to detect IgG antibody to H. pylori.Results : The overall seroprevalence observed was 46.6% and showed no statistical diffrerence between female (45.9%) and male (47.2%). The seroprevalences in children (neonate-15 y) and adult (16-79 y) were 17.2% and 66.9%, respectively. According to multivariate analysis, variables such as sex, age, geographic area, crowding (number of person per room) in childhood, economic status in childhood, and types of housing in childhood were significantly and independently associated with H. pylori seroprevalence of adults. In children, age, geographic area, income, mother's education, and drinking water source were significant risk factors of H. pylori infection. Conclusion : Socioeconomic condition and close person to person contact in childhood are the significant determinants for H. pylori infection in adult. Drinking water source is an another important risk factor for H. pylori infection in children, suggesting the fecal to oral transmission in Korea.(Korean J Med 59:376-387, 2000)
상부우장관 증사이 없는 한국인에서 Helicobacter pylori 감염의 혈청학적 유병률에 관한 전국적 역학조사
김나영(Na Young Kim),김재규(Jae Gyu Kim),김진호(Jin Ho Kim),김학양(Hak Yang Kim),김상우(Sang Woo Kim),김재준(Jae Jun Kim),노임환(Im Hwan Roe),심재건(Jae Geon Sim),안형식(Hyeong Sik Ahn),윤병철(Byung Chul Yoon),이상우(Sang Woo Lee),이용 대한내과학회 2000 대한내과학회지 Vol.59 No.4
Background : Helicobacter pylori infection occurs throughout the world and causes various gastroduodenal diseases in all age groups. The prevalence of H. pylori infection varies among countries and races. The aim of this study was to evaluate the seroprevalence of H. pylori infection in healthy people in Korea. Methods : From March 1998 to October 1998, 5,732 asymptomatic subjects responded to the self-assessment questionnaires from 54 hospitals were enrolled. Serum level of anti-H. pylori IgG was measured by ELISA test. Results : The overall prevalence of H. pylori infection was 46.6% and showed no significant difference between male (47.2%) and female (45.9%). According to the geographic areas, the highly prevalent provinces were Kangwon (53.4%), Cheju (52.9%) and Jeonra provinces (50.6%), while Seoul (41.9%) was the lowest prevalent area. The seroprevalence increased with age and was the highest at 40's (78.5%). The characteristic feature of this study was that the infection rate increased steeply in three age groups (10-12, 16-19 years old and 30's). In Seoul, there was no different prevalence rate among the districts studied.Conclusion : The nation-wide seroprevalence of H. pylori infection in Korea is higher than that of the developed countries. We hope that this study provides the landmark for the study of H. pylori infection in Korea.(Korean J Med 59:388-397, 2000)
한국인에서 Helicobacter pylori 감염의 진단에 있어 Genedia™ H . pylori ELISA 검사의 진단 정확도
정인식(In Sik Chung),김상우(Sang Woo Kim),고재성(Jae Sung Go),김나영(Na Young Kim),김재규(Jae Gyu Kim),김진호(Jin Ho Kim),김학양(Hak Yang Kim),김재준(Jae Jun Kim),노임환(Im Hwan Roe),심재건(Jae Geon Sim),안형식(Hyeong Sik Ahn),윤병철(By 대한내과학회 2001 대한내과학회지 Vol.61 No.1
N/A Background: Genedia™ H. pylori ELISA is a newly developed diagnostic method which detects serum anti-H. pylori IgG antibody. The aim of this study was to assess the accuracy of Genedia™ H. pylori ELISA for the diagnosis of H. pylori infection in Korean population. Methods Genedia : H. pylori ELISA and GAP-IgG were performed in 353 adult sera and Pyloriset-IgG EIA in 184 subjects. In children, 43 serum samples were tested with Genedia™ H. pylori ELISA. H, pylori infection was determined by rapid urease test, histology, culture or (13)C-urea breath test in adults. In children, the subject was considered to he H. pylori positive if (13)C-urea breath test was positive. Results: In adults, the sensitivity and specificity of Genedia™ H. pylori ELISA were 93.2% and 83.5% with positive and negative predictive values of 85.1% and 92.5%. Those for GAP-IgG and Pyloriset-IgG EIA were 67.2%, 82.4%, 79.3%, 71.4% and 89.1%, 88.4%, 71.9%, 96.1%, respectively. In children, sensitivity, specificity, positive and negative predictive values of Genedia™ H. pylori ELISA were 80%, 84.8%, 61.5%, and 93.3%. Sensitivity and negative predictive value of Genedia™ H. pylori ELISA were significantly higher than those of GAP-IgG (93.2% vs. 67.2%, p<0.005 and 92.5% vs 71.4%, p<0.005, respectively). Conclusion : Genedia™ H pylori ELISA is a relatively accurate method for the serodiagnosis of H pylori infection in Korean subjects compared to GAP-IgG. These results may suggest the clinical use of Genedia™ H. pylori ELISA for epidemiological studies of H. pylori infection in Korea. (Korean J Med 61:17-23, 2001)