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신종환,안기찬,서승석,김영창,최장석 인제대학교 1999 仁濟醫學 Vol.20 No.1S
Lipoma Arborescens는 지방종의 이형으로 노년의 퇴행성 관절 질환, 만성 류미티스성 관절염, 후외상성 관절 병변으로 인해 주로 슬관절에 생기는 활액막하 지방조직의 응모성(Villous), 수지상(Arborscent, Tree-like) 비후 병변으로 드문 관절내 양성 연부종양이다. 저자들은 우측의 족근관절 종물을 주소로 내원한 35세 여자 환자의 Lipoma Arborescens 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Lipoma Arborescens is a rare intraarticular benign Lesion usually found in the knee wrist. We present a case of Lipoma Arborescens with review of literatures, in right ankle joint, thirty five years old woman, histologically characterised by diffuse replacement of the subsynovial tissue by mature fat cells, which was treated by excision and synovectomy and no evidence of recurrence so far eight months follow-up.
신종환,김경수,한준희 한국유전학회 2014 Genes & Genomics Vol.36 No.6
Transcriptional regulation is a complex processmediated by coordinated assembly complexes to ensuretemporal and spatial gene expression. The AT-hook is aDNA-binding motif originally described in the highmobility group A of non-histone chromatin components. The AT-hook proteins bind to the minor groove of adenine–thymine (AT) rich regions of DNA and act as transcriptionalcofactors coordinating nucleoproteins duringtranscriptional regulation. In this study, a genome-wide insilico analysis of AT-hook proteins was performed on theascomycete plant pathogenic fungus, Magnaporthe oryzae. Quantitative real-time RT-PCR analysis revealed differentialexpression patterns of MoATH genes during developmentand plant infection. To increase our understandingof the functional role of AT-hook proteins in M. oryzaedevelopment and pathogenicity, a deletion mutant of Mo-ATH10 was functionally characterized. Targeted deletionof MoATH10 significantly increased pigmentation andconidiation, indicating that MoATH10 is negativelyinvolved in the regulation of pigmentation and conidiationin M. oryzae. Pathogenicity assays revealed that theDMoath10 mutant was less virulent. The reduced diseasedevelopment of the DMoath10 mutant was due to a partialdefect in invasive growth inside plant cells, but notappressorium-mediated penetration. These results suggestthat MoATH10 is important for growth, development, andvirulence in M. oryzae.