SM-2000의 항피로 효과에 대한 임상적 연구

신선미,고흥,Shin, Seon-Mi,Ko, Heung 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.3

Objectives : This study was performed to investigate the antifatigue effect of SM-2000 on fatigued and stressed people. Methods : This study was carried out on 23 healthy people who have fatigue and stress. 11 people as the mentally-stressed group were examined by subjective symptoms of fatigue and blood cortisol test. They drank SM-2000 for seven days. SM-2000 was made up herbs which were used for fatigue. After that they were again examined by subjective symptoms of fatigue and blood cortisol test. 12 people as the physically-fatigued group were examined with fatigue biomarkers and exercise test. They also drank SM-2000 for seven days. After that they were again examined with fatigue biomarkers and exercise test. Results : Cortisol level, subjective symptoms of fatigue scores and physical, mental, and neuro-sensory symptoms of fatigue scores after drinking SM-2000 were not significantly increased compared with before drinking SM-2000 in the mental stressed group. SM-2000 significantly decreased lactate, glucose, and phosphorous levels, and running time after drinking SM-2000 was significantly suppressed compared with before drinking SM-2000 in the physically-fatigued group. Conclusions : On the basis of these results, SM-2000 had a clinical antifatigue effect in physically-fatigued people.

SM-2015의 혈중 알코올 분해 및 숙취 개선 효과

신선미,박선영,김태연,Shin, Seon-mi,Park, Sun-young,Kim, Tae-yeon 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.1

Objectives: This study investigated the effect of SM-2015 on blood alcohol clearance and hangover. We undertook this study to test whether SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Methods: Twenty healthy volunteers participated in this randomized crossover study. All participants were classified between an SM-2015 intake group (test group) and a non-intake group (control group). The primary outcome measure was the difference in blood alcohol concentration and hangover severity scores between the test and control groups. The secondary outcome measure was the difference in a liver function test (LFT) between the test and control groups. Results: After alcohol exposure, the sensitivity scores of blood alcohol concentration and hangover symptoms (sleepiness, dizziness, nausea, weakness, stomach pain, diarrhea, and concentration disorder) were significantly decreased in the SM-2015 intake group compared with the non-intake group. There were no differences in the LFT results between the SM-2015 intake group and the non-intake group. Conclusions: SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Larger studies are required to confirm these findings.

골다공증 다빈도 처방과 구성 약물의 네트워크 분석 - 오아시스 검색을 중심으로

신선미,고흥,Shin, Seon-mi,Ko, Heung 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.4

Objectives: This study analyzed, through network analysis and data mining analysis, the relationship between herbs used in osteoporosis prescriptions, diversified the analysis of osteoporosis-related prescriptions, and analyzed the combination of herbs used in osteoporosis-related prescriptions. Methods: The prescriptions used in osteoporosis treatment and experiments were established by conducting a full survey of the papers published by the OASIS site. A database for osteoporosis-related prescriptions was established, herbs were extracted, and the frequency of frequent herbs and prescriptions were investigated using Excel (MS offices ver. 2013). Using the freeware R version 4.0.3 (2020-10-10), igraph, and arules package, network analysis was performed in the first second of prescription composition. Results: Among the osteoporosis-related prescriptions, the most studied prescriptions are as follows.: Yukmijihwang-tang (六味地黃湯) and Samul-tang (四物湯). In the osteoporosis prescription network, herbs with connection centrality, proximity centrality, mediation centrality, and eigenvector centrality appeared in the order of Rehmanniae Radix Preparata, Angelicae Gigantis Radix, Poria Sclerotium, Paeoniae Radix, and Glycyrrhizae Radix et Rhizoma. After extracting the herbal combination network, including the corresponding herbs, and clustering it, it can be divided into drugs of the Yukmijihwang-tang (六味地黃湯) series and the Samul-tang (四物湯). Conclusions: This study could assist researchers in diversifyingy formula analysis in future studies. Moreover, the herbal combination used in osteoporosis prescriptions could be used to search for osteoporosis prescriptions in other databases or to create a new prescription.

발기부전 처방에 사용되는 쇄양(鎖陽)이 음경해면체 이완에 미치는 영향

신선미,박선영,Shin, Seon-mi,Park, Sun-young 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.4

Objective: This study aimed to examine the relaxation effects and underlying mechanisms of Cynomorii herba (CH) extract in isolated rabbit corpus cavernous tissues.Methods: We experimented with CH extract (0.01-3.0 mg/mL). Nω-nitro-L-arginine (L-NNA) was experimented before the CH extract to contracted strips induced by phenylephrine (PE, 1 μM)and compared with nonexperimented. In addition, we experimented with calcium chloride (Ca²⁺, 1 mM) after pretreatment of the CH extract in Ca²⁺-free Krebs-Ringer solution to contracted strips induced by PE. The cell viability and nitric oxide (NO) concentration of human umbilical vein endothelial cells (HUVECs) were measured by an methylthiazol-2-yl-2, 5-diphenyl tetrazoliumbromide (MTT) assay and Griess reagent system. The ratio of smooth muscles to collagen fibers, in addition to eNOS- and PDE-5-positive reactions, was examined by histochemical and immunohistochemical staining.Results: The CH extract significantly induced the relaxation of the cavernous strips, and the pretreatment with L-NNA inhibited CH extract-induced relaxation. The L-NNA pretreatment reduced the increased contraction induced by the addition of Ca²⁺in Ca²⁺-free solution. Furthermore, the NO concentration of the HUVECs increased. When the CH extract was applied to the corpus cavernosum of the penis (CCP) of Sprague Dawley rats, the ratio of smooth muscles to collagen fibers by PE and the formation of eNOS around the helicine artery increased. However, the CH extract treatment decreased PDE-5 positive reactions.Conclusions: These results show that the relaxation effects induced by the CH extract are associated with the suppression of the influx of extracellular Ca²⁺ via the production of NO and eNOS and inhibition of PDE-5.

한방병원에 내원한 만성 피로환자와 건강인의 심박변이도 측정을 통한 피로 진단 지표 연구

신선미(Seon-mi Shin),김기태(Ki-tae Kim),고흥(Heung Ko) 한의병리학회 2015 동의생리병리학회지 Vol.29 No.5

무용동작치료가 시설보호아동의 자아탄력성 향상에 미치는 효과

신선미(Shin, Seon Mi),곽현주(Kwak, Hyun Ju) 한국통합예술심신치유학회 2015 통합심신치유연구 Vol.2 No.1

본 연구는 무용동작 치료가 시설보호아동의 자아 탄력성 향상에 미치는 효과를 알아보고자 실시되었다. 무용동작 치료 프로그램의 효과분석을 통해 치료현장에서 예술치료의 적용 및 실질적인 자료를 제시하는데 그 의의가 있다. 본 연구에서는 연구문제의 검증을 위하여 C시에 위치한 S아동 양육시설 초등학교 1학년부터 6학년에 재학중인 20명의 아동을 대상으로 6주간 총 12회기의 프로그램을 실시하였으며, 무용동작 치료프로그램 사전과 사후에 자아 탄력성의 변화를 분석 하였다. 자아 탄력성의 하위요인은 대인관계, 활력성, 감정통제, 호기심, 낙관성으로 분류 하였고, 본 연구에서 사용한 무용동작 치료 프로그램은 인간의 기본적인 신체 움직임과 무용의 예술적, 창의적, 즉흥적인 동작의 표현 특성을 치료의 매체로 사용하여 자기발달과 자기표현, 신체적인 건강을 유지, 증진시키는 예술치료기법으로 인지 발달 , 정서발달 , 사회성향상을 위한 여러 가지 프로그램 중 자아 탄력성에 긍정적인 영향을 주는 프로그램으로 구성하여 실시하였다. 본 연구결과를 요약하면 시설보호아동들에게 무용동작 치료를 실시한 결과 전체 자아 탄력성 점수의 변화에 유의한 차이를 보이며 긍정적인 영향을 주었다. 결론적으로 본 연구를 통해 무용동작 치료가 다양한 스트레스 상황에 놓여있는 시설보호아동에게 능동적인 대인관계와 활력성, 호기심 향상과 같은 인지적, 정서적, 행동적 요소를 모두 포함하는 자아 탄력성 향상에 효과적임을 확인할 수 있었다. The purpose of this study is to analyze the effect of dance movement therapy program on the self-resilience of institutionalized children and to suggest the practical data for the application of art therapy in the fields. To verify the above research problems, a program with a total of 12 sessions was conducted targeting a total of 20 students (from year 1 to year 6) at S Child Care Facility in C city. The variation of self-resilience before and after the implementation of dance movement therapy program was analyzed. The sub-factors of self-resilience were divided into interpersonal relationship, vitality, emotion control, curiosity and optimism. The dance movement therapy program, an art therapy technique, uses basic human movement and the expressional characteristics of artistic, creative and spontaneous motion as a medium for maintaining and improving self-development, self-e x pression and physical health. O f a number of programs for cognitive development, emotional development and the development of sociality, programs having a positive effect on self-resilience were used. The results of this

학년에 따른 청소년의 건강상태와 증상인식에 대한 단면조사 연구

신선미(Seon Mi Shin),박정수(Jeong Su Park),고호연(Ho Yeon Go),김동수(Dong Su Kim),성현경(Hyun Kyung Sung) 한의병리학회 2018 동의생리병리학회지 Vol.32 No.6

AMS 설문지 검사를 이용한 성기능 장애 환자의 腎氣丸 투여 10례에 대한 임상보고

신선미(Seon Mi Shin),고흥(Heung Ko),김기태(Gi Tea Kim),김호현(Ho Hyun Kim),박선영(Sun Young Park) 한의병리학회 2014 동의생리병리학회지 Vol.28 No.5

홍화, 홍화씨 추출물이 MC3T3E1 세포의 골분화 과정에 미치는 영향

유성률,신선미,Yu, Sung-ryul,Shin, Seon-mi 대한한방내과학회 2015 大韓韓方內科學會誌 Vol.36 No.4

Objectives This study investigated the effect of purified safflower (Carthamus tinctorius Linne) and safflower seed (Carthamus tinctorius L. seed; CS) extract, using hot water and ethanol extract methods , on the osteogenic differentiation of MC3T3E1 cells.Methods The safflower and safflower seed were extracted with hot water and ethanol. The samples were concentrated by a rotary evaporator and then freeze-dried using a freeze-dryer. The MC3T3E1 cells were propagated and maintained in DMEM (Gibco) containing 10% FBS and a 1% antibiotic antimycotic solution. To induce osteogenic differentiation, the cells were treated for 14 days with DMEM with 10 mM β-glycerophosphate and 50 μM ascorbic acid. Extract doses were confirmed by the results of an MTT assay, and treatment of the extracts was performed in a differentiation medium every two days. The ALP staining and activity were tested after osteogenic differentiation for five days, and after 14 days, osteogenic differentiation was determined by alizarin red S staining. The mRNA expressions of osteogenic-related genes were quantified using quantitative real-time PCR.Results In the results of the MTT assay, all concentrations of safflower extracts had no toxicity in the MC3T3El cells. But in the groups of 100 ng/ml and 200 ng/ml concentrations of safflower seed extracts, the cell viability was significantly reduced by up to 40-50%. So we fixed the treatment concentration of the extract at 50 ng/ml. In the ALP and alizarin red S staining, all extract groups increased osteogenic differentiation compared with the control group. The water-safflower extract group showed the highest mRNA level of Alp, Runx2, and Dlx5 genes. The mRNA level of Ocn, an osteogenic gene related to late-stage differentiation, in the ethanol-safflower extract group increased the mineralization more significantly than in other groups.Conclusions These data suggest that the extract of safflower increases the osteoblastic differentiation activates of MC3T3E1 cells like the extract of safflower seed. The water-extract and ethanol-extract of safflower have effects on different stages of osteogenesis in MC3T3El. Not only safflower seed but also safflower will be useful therapeutic reagents for age-associated chronic diseases such as osteoporosis.

찾아가는 한의사 주치의 사업 성과분석 연구

박정수,신선미,김효선,성현경,고호연,Park, Jeong-Su,Shin, Seon Mi,Kim, Hyo-Sun,Sung, Hyun Kyung,Go, Ho-Yeon 대한예방한의학회 2018 대한예방한의학회지 Vol.22 No.1

Objectives : The purpose of this study was to examine the effectiveness and satisfaction of visiting Korean Medicine doctor program. Method : The senior center visiting Korean Medicine doctor program was conducted in ten senior centers in Seongnam city from April 2016 to December 2016. Korean Medicine doctors were assigned senior center one by one. The program consisted of health lectures and health counseling. The health lectures embraces stroke, musculoskeletal disease, dementia, depression and self care for the elderly Results : A total of 194 elderly persons participated the program. The self-health awareness level were changed from $50.86{\pm}25.31$ to $57.17{\pm}24.62$ (p-value=0.003). The physical pain level was decreased from $5.33{\pm}2.99$ to $5.04{\pm}2.86$. The quality of life were changed from $0.791{\pm}0.155$ to $0.792{\pm}0.144$ (p-value=0.923). Overall satisfaction of visiting Korean Medicine doctor program was $9.36{\pm}2.11$. The need for sustainability for visiting Korean Medicine doctor program was $9.76{\pm}0.60$. Conclusions : The study demonstrated that visiting Korean Medicine doctor program had a positive effect on the health awareness level. The overall satisfaction and further need were high. Further program for senior center will be needed.