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윤성재 ( Yun Seong Jae ),박형석 ( Park Hyeong Seog ),성환태 ( Seong Hwan Tae ),김원석 ( Kim Won Seog ),이주흥 ( Lee Ju Heung ),양준모 ( Yang Jun Mo ),이일수 ( Lee Il Su ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.3
Cutaneous T cell lymphoma (mycosis fungoides/Sezary syndrome) is a clonal malignacy of helper (CD4+) T lymphocytes usually first detected in the skin. In 8-55% of mycosis fungoides, the malignant T cell clone undergoes, cytologic transformation characterized by pleomorphic, large cells with prominent nucleoli, resulting in the morphologic appearance of a large cell lymphoma. The prognosis of large cell transformation of mycosis fungoides is poor, so detection of cytologic transformation is important to decide further treatment. We report a case of 22-year-old mycosis fungoides patient who developed large cell transformation during photochemotherapy (PUVA). (Korean J Dermatol 2004;42(3):324~327)
윤성재 ( Yun Seong Jae ),박경호 ( Park Gyeong Ho ),성환태 ( Seong Hwan Tae ),이동윤 ( Lee Do Yun ),한정호 ( Han Jeong Ho ),이일수 ( Lee Il Su ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.3
N/A Background: Dermatofibromas are common benign tumors which occur in the skin. They have been divided into fibrous lesions, composed entirely or almost entirely of fibroblasts and collagen, and cellular lesions composed to a significant degree of phagocytic cells with the appearance of histiocytes. A cellular variant characterized by increased cellularity, storiform arrangement, larger size, and location in the deep dermis, often with extension into the superficial subcutaneous tissue may be difficult to differentiate from dermatofibrosarcoma protuberans. There is an incessant controversy over the histogenesis of dermatofibromas, although many authors consider that these tumors derive from primitive mesenchymal cells. The recent development in immunohistochemical staining technology and ultrastructural study revealed various cellular proliferation in the lesion, including fibroblast, histiocyte and myofibroblast. Objective: Our purpose was to study by immunohistochemistry the differences between fibrous and cellular dermatofibromas and to find the relationship between the myofibroblast and the histogenesis of dermatofibroma. Methods: We will select 36 cases of dermatofibromas which include 27 fibrous and 9 cellular types. We have studied the immunophenotype of 36 dermatofibromas using antibodies against vimentin, smooth muscle actin, desmin, CD34, factor XⅢa, CD68 and MMP 11. Results: All dermatofibromas were positive for vimentin, smooth muscle actin, and factor XⅢa, but negative for desmin and CD34. All cellular type were positive for CD68, but 24/27 of the fibrous type were positive for CD68. MMP 11 was positive in 6/9 of the cellular type and 25/27 of the fibrous type. The degree of staining for vimentin, factor XⅢa, CD68, and MMP 11 was not different in both types. But the degree of staining for smooth muscle actin in the fibrous type was higher than in the cellular type. Conclusion: The differences in the degree of staining for smooth muscle actin and the positivity for CD68 suggest the possibility of a different differentiation of dermatofibroma between cellular and fibrous types. the prominent vimentin and smooth muscle actin immunoreactivity and desmin non-reactivity may suggest that the myofibroblast may play a role, in part, for developing dermatofibromas. Further investigations with ultrastructural study using electron microscopy and double/triple immunohistochemical staining would be necessary. (Korean J Dermatol 2004;42(3):256~263)
윤성필,성환태,인승균,이승규,임태균,최광성 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.1
Congenital triangular alopecia is an uncommon nonscarring form of alopecia. It presents with isolated alopecic patch at the frontotemporal area of the scalp. Although previously considered congenital, this condition usually is discovered after 2 years of age and, more recently, is thought to be acquired. We report a case of congenital triangular alopecia in a 12 month old female who had the lesion since birth. (Korean J Dermatol 2004;42(1):114~115)