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      • 사염화탄소에 의한 간손상에 미치는 현호색의 효과 및 그 기전

        서인옥,정춘식,정기화 德成女子大學校 藥學硏究所 2000 藥學論文誌 Vol.11 No.1

        본 연구에서는 현호색의 methanol 추출물에 대하여 사염화탄소에 의한 간 손상 보호효과를 확인한 후 이를 hexane, chloroform, butanol 및 물로 계통분획하여 사염화탄소에 의한 간 손상 보호효과를 검색하였다. 이 결과 현호색 물분획물이 유의성 있는 간 보호효과를 보임으로써 간손상 보호효과를 확인하고 그 기전을 밝히고자 하였다. 그 결과 혈액중의 ALT활성 및 cholesterol함량은 사염화탄소 단독투여군에 비하여 감소하였으며 간조직의 TG와 지질과산화물 함량은 사염화탄소 단독투여군에 비하여 감소하여 사염화탄소에 의한 지방의 축적이나 세포막의 손상은 억제된 것으로 보인다. 기전연구를 위하여 측정한 CYP함량과 calcium함량은 사염화탄소 단독투여군에 비하여 감소하였으며 GST활성도는 사염화탄소 단독투여군에 비하여 증가하였다. 항산화 효소의 유도로 인하여 증가할 것으로 기대한 SOD, GPX, CAT활성도는 모든 처치군에서 감소하는 경향을 보여 간손상 보호 효과는 free radical scavenging effect 보다는 CYP함량의 감소와 CCB로서의 작용 및 GST활성도의 증가에 기인한 것으로 생각된다. Protective effect of Corydalis ternata against the carbon tetrachloride-induced toxicity was investigated. Carbon tetrachloride(CCl_4) induces hepatotoxicity due to the reactive free radical(CCl_3 ·) generated by cytochrome P-450 enzyme. We examined effects of hexane, chloroform, butanol and water fractions prepared from the Corydalis ternata methanol extract. Rats were treated with those for 3 days, and liver microsomes and cytosols were prepared at 24 hour after last treatment. Hepatoprotective activity of the water fraction was higher than that of other fractions. To examine mechanism of the hepatoprotective effect of Corydalis ternata, we measured contents of malondialdehyde(MDA), cytochrome P450(CYP), glutathione, calcium as well as the activities of NADPH-CYP reductase, glutathione S-transferase(GST), superoxide dismutase(SOD), glutathione peroxidase(GPX) and catalase. The fraction inhibited production of MDA, contest of CYP and calcium in liver of water fractions-treated rats as compared with those of CCl_4-treated rats. The GST activity was increased. We speculate that the O_2 radical scavenging activities of the water fraction might play a key role in the mechanism opposing the progression of CCl_4-induced hepatotoxicity, but the activities of SOD, GPX, CAT were decreased. These results suggest that the mechanism might be mainly due to the decrease of CYP contents, act as calcium channel blocker and increase of GST activity rather than O_2 radical scavenging activities.

      • 외국인투자기업의 투자환경에 관한 연구 - 노동환경을 중심으로

        서인옥(In-Ok Seo) 인하대학교 산업경제연구소 2006 경상논집 Vol.20 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

          Foreign investments in Korea had concentrated on the manufacturing sector utilizing cheap but high quality labor until 1980s. However, since then, the investments have begun to target more on services and financial markets following the national policy of opening the economy.<BR>  These investments are firms who have their mother companies in the countries of origin, establish their subsidiaries in other countries to produce and sell products according to international business strategies. In light of this, therefore, confrontational industrial relations, excessive regulations and high distribution costs create difficulties for them to do businesses. Particularly, in industrial relations, illegal activities beyond the boundaries of laws and principles are becoming obstacles that drag investments of both domestic and foreign invested companies.<BR>  Foreign companies that are considering to invest in Korea or those who have already invested in Korea recognize difficulties in the area of labor as the most important ones. This is, at the same time, also the area where there is much room for improvement.<BR>  The possible solutions would first be to study and analyze labor-management conflicts to identify their causes, design various measures to correct them, continue dialogues between labor and management and try to understand cultural and social differences. In addition, both labor and management must acknowledge their rights and responsibilities correctly and enforce them throughly so that a win-win labor-management culture can take root.<BR>  Second, wage increase must be based on the productivity standards. The principle of adjusting wages within the level of increase in productivity needs to be established to ensure firms" competitiveness and fair gain sharing between labor and management.<BR>  Third, industrial relations based on laws and principles must be settled. Since labor movements without due respect of laws and principles are major impediments to foreign investment, stern enforcement of laws is a matter of urgency to prevent illegal strikes in both domestic and foreign firms. Institutional arrangements will also need to be improved.

      • KCI등재후보
      • 실내와 실외놀이터에서의 유아의 놀이행동

        유연,서인 啓明大學校 生活科學硏究所 2010 科學論集 Vol.36 No.-

        The purpose of this study was to analyze play behavior of young children in indoor and outdoor playgrounds and to analyze the differences in their play behavior according to gender. The study observed 80 children under 4 years old in educational institutions in Daegu and Gyeongsangbuk-do province. An observation instrument for young children's play behavior(Shin, Dong-Joo 1997 Kim, Myung-Jun, 2000), which Frost developed in 1992, was used. The results of the study showed the following: First, there was a difference in play behavior according to the type of playground. Social-cognitive play behavior, such as parallel play and group play, were expressed more in indoor playgrounds. Non-play behaviors, such as conversion behavior and attack behavior, and other play behavior, such as search behavior, gossip, and rude body struggle, were more frequent in outdoor playgrounds. Second, there was a difference in play behavior according to gender. Boys expressed more social-cognitive play behavior: parallel constructive play in indoor playgrounds and games with rules of group play in outdoor playgrounds. To summarize, new forms of children's playgrounds, adopting the differences of play behavior according to playground types and gender, should be considered in order to raise the quality of playgrounds.

      • SCOPUSKCI등재

        수술과 마취후 발생한 간독성의 분석

        전재규,서인옥,배정인 대한마취과학회 1991 Korean Journal of Anesthesiology Vol.24 No.2

        25 Patients were received major spinal surgeries at main operating theater of Kangnam General Hospital from May 1990 to December 1990 by using the Haemonetics cell saver which was employed as an intraoperative blood salvage and autologous blood transfuser . The products of washed red blood cells were an average of 1490 cc packed RBC per case. Under the Light Microscopy, Washed RBC disclosed the morphologies of normal RBC size and shape. Fragmented RBCs or cell debris were not found and in one case agglutinated and denaturated RBCs were seen. While 20 patients were received spinal surgery prior to the untilization of cell saver, an average of 7.85 units of banked whole blood was transfused compared with 5.55 units in the cases of using the cell saver (p<0.05). Homologous banked blood utilization during spinal surgery declined more than 30% with the use of the cell saver. There was no evidence of infection, renal and/or hepatic failure related to the use of the cell saver. Haemonetics cell saver appeared to be safe, efficient and more over in some instanes life saving.

      • 전문대학 간호대학생의 임상실습 경험의 의미

        양경희,고가연,고정,김란,김지윤,김윤영,박병준,박순,박선정,서인,손유림,오수민,전경덕,진은영 한국간호연구학회 2017 한국간호연구학회지 Vol.1 No.1

        Purpose : The purpose of this study was to examine the clinical practice experience of third- and fourth-year nursing students in junior colleges in an effort to shed light on the nature of the meaning of their experiences to have a profound understanding of it. Methods : The subjects in this study were 20 selected juniors and seniors who majored in nursing science in 10 junior colleges across the nation. The students had experience of practice in adult health nursing, women’s health nursing, child health nursing and gerontological nursing. In-depth interviews were conducted to gather data on their experiences of practice from July 21 to August 6, 2017. The collected data were analyzed by Colaizzi’s method. Results : 36 meanings were constructed, and 13 themes and six theme clusters were extracted: “Ambivalence about field practice,” “confused identity,” “lack of hands-on nursing experience and diversity,” “unfriendly environments for practice,” “being on the way to becoming a nurse,” and “practical education of higher quality is desperately needed.” Conclusion : Given the findings of the study, how to step up the development of clinical practice in junior colleges should carefully be considered, and the development and application of programs on clinical practice process are required to improve the qualifications of nursing college students as future professional nurses.

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