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위선암과 장상피화생에서 Cdx-2 유전자 발현에 대한 연구
백창희 ( Chang Hee Paik ),한동수 ( Dong Soo Han ),이승현 ( Seung Hyun Lee ),정용우 ( Yong Woo Chung ),김종표 ( Jong Pyo Kim ),손주현 ( Joo Hyun Sohn ),함준수 ( Joon Soo Hahm ),오영하 ( Young Ha Oh ),박용욱 ( Yong Uk Park ) 대한소화기학회 2004 대한소화기학회지 Vol.44 No.4
Background/Aims: The Cdx-1 and Cdx-2 genes are intestinal transcription factors that may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. The Cdx-1 and Cdx-2 are expressed in the epithelium of the small in
포스터 전시 : 하부위장관 4 ; 스테로이드에 반응하지 않는 십이지장-공장 누공을 동반한 베체트 장염에서의 cyclosporine 치료 1예
백창희 ( Chang Hee Paik ),박근태 ( Geun Tae Park ),이성희 ( Sung Hee Lee ),이오영 ( Oh Young Lee ),윤병철 ( Byung Chul Yoon ),최호순 ( Ho Soon Choi ),함준수 ( Joon Soo Hahm ),이민호 ( Min Ho Lee ),이동후 ( Dong Hoo Lee ),기춘석 ( 대한소화기학회 2002 대한소화기학회 추계학술대회 Vol.2002 No.-
Escherichia coli O111 감염에 의한 용혈 요독증이 동반된 출혈 대장염
김종표 ( Jong Pyo Kim ),한동수 ( Dong Soo Han ),백창희 ( Chang Hee Paik ),정용우 ( Yong Woo Chung ),김진배 ( Jin Bae Kim ),손주현 ( Joo Hyun Sohn ),함준수 ( Joon Soo Hahm ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.5
Shiga toxin producing E. coli (STEC) may cause severe hemorrhagic colitis followed by hemolytic uremic syndrome (HUS). In Korea, there had been a few case reports of HUS by STEC, mostly due to O157 serotype. The reports of HUS caused by STEC non-O157 sero
대장암의 간 전이에 대한 사이버나이프 치료 후 발생한 국소 식도 궤양 1예
정용우 ( Yong Woo Chung ),한동수 ( Dong Soo Han ),백창희 ( Chang Hee Paik ),김종표 ( Jong Pyo Kim ),최정혜 ( Jung Hye Choi ),손주현 ( Joo Hyun Sohn ),함준수 ( Joon Soo Hahm ) 대한소화기학회 2006 대한소화기학회지 Vol.47 No.6
사이버나이프는 정위 방사선 수술을 위하여 고안된 영상에 의해 유도되는 일종의 로봇 시스템이다. 사이버나이프는 초기에는 주로 두 개 내 양성 또는 악성 병소를 치료하기 위하여 개발되었으나 방사선 조사 때 틀이 필요없다는 이점으로 인해 최근에는 흉부와 복부의 종괴 치료에 도입되었다. 하지만 이에 대한 임상 경험은 아직까지 제한적이어서 이러한 치료에 의한 합병증 보고 또한 많지 않다. 저자들은 대장암의 간 전이에 대한 사이버나이프 치료 후 발생한 국소 식도궤양 1예를 경험하여 보고한다. CyberKnife is an image-guided robotic system designed for stereotactic radiosurgery. It uses the combination of robotics and image guidance to deliver concentrated and accurate beams of radiation to intracranial and extracranial targets. Although the frameless nature of the CyberKnife allows tumors in the chest and abdomen to be treated as well, complications associated with CyberKnife treatment have not been established yet due to its short clinical experience. We describe a case of Localized esophageal ulcerations after CyberKnife treatment for metastatic hepatic tumor of colon cancer. (Korean J Gastroenterol 2006;47:449-453)
정재윤 ( Jae Yoon Jeong ),손주현 ( Joo Hyun Sohn ),손병관 ( Byoung Kwan Son ),백창희 ( Chang Hee Paik ),김석환 ( Seok Hwan Kim ),한동수 ( Dong Soo Han ),전용철 ( Yong Chul Jeon ),이민호 ( Min Ho Lee ),이동후 ( Dong Hoo Lee ),기춘 대한소화기학회 2007 대한소화기학회지 Vol.49 No.2
목적: 알코올 간염은 급성 염증증후군으로 높은 이환율과 사망률을 보인다. 전통적으로 discriminant function (DF) 점수와 Child-Turcotte-Pugh (CTP) 점수가 알코올 간염 환자의 예후를 예측하는 지표로 사용되어 왔다. 최근에 model for end-stage liver disease (MELD) 점수가 알코올 간염 환자에 예후 예측에 이용되고 있고, 일부 연구자들은 중증 알코올 간염 환자에서 다른 점수에 비해 예후를 예측하는 데 우월한 지표로 인식하고 있다. 현재까지 대부분의 연구들은 서양인을 대상으로 하였기 때문에 저자는 한국인에서 알코올 간염 환자들의 예후 예측인자로 DF 점수, CTP 점수, MELD 점수를 비교하여 평가하고자 하였다. 대상 및 방법: 병원 기록을 통해 총 138명 중 74명이 알코올 간염 환자의 포함기준을 만족하였다. 환자 기록은 후향으로 분석하였고 입원 당시의 인구 통계학적인 자료, 임상 진찰의 결과와 표준 검사실 결과 등을 기록하였다. 생존 여부는 병원 기록과 전화 추적을 통해 확인하였다. 결과: 단변량 분석을 통해 90일 사망에 대한 연관 있는 인자로는 복수, 간성혼수, 비장비대, 프로트롬빈 시간(international normalized ratio, INR), CTP 점수와 DF 점수(p<0.05)였으나, MELD 점수는 연관성이 없었다. 다변량 분석에서는 CTP 점수만이 통계적으로 유의하였으나(p=0.012), 다른 지표들은 모두 통계적으로 유의하지 않았다. CTP 점수에 따른 90일 사망률이 A급 0%, B급 7.9%, C급 32.1%로 A급과 B급에서는 사망률의 차이가 없었으나, C급에서 유의하게 증가하였다(p<0.05). DF 점수에 따른 90일 사망률은 32점 미만에서 8.3%, 32점 이상에서 30.8%로 점수가 높을수록 유의하게 증가하였다(p<0.05). 그러나 MELD 점수에 따른 사망률은 11점 미만에서 16.1%, 11점 이상에서 16.3%로 점수에 따른 연관성이 없었다(p= 0.7). 사망률 예측에 대한 CTP 점수 10점의 민감도와 특이도는 각각 72.7%와 69.6%였고, DF 점수 32점의 민감도와 특이도는 각각 72.7%와 79.0%로 통계적으로 유의하였으나, MELD 점수는 통계적인 유의성이 없었다. 결론: 이번 연구에서 한국인에서 알코올 간염 환자의 예후를 예측하는 데 기존에 널리 이용되어 온 CTP 점수와 DF 점수는 유용한 데 반해, MELD 점수는 유용하지 못하였다. Background/Aims: Alcoholic hepatitis is an acute or acute-on-chronic inflammatory syndrome associated with significant morbidity and mortality. Traditionally, Maddrey discriminant function (DF) score and Child-Turcott-Pugh (CTP) score have been used for stratifying the prognosis of alcoholic hepatitis. Recently, the model for end-stage liver disease (MELD) score has been applied to alcoholic hepatitis and some investigators consider MELD score as a better prognostic indicator for severe alcoholic hepatitis. Therefore, this analysis was aimed to compare MELD score with DF and CTP scores for predicting the short-term mortality in Korean patients with alcoholic hepatitis. Methods: The medical records of patients hospitalized with alcoholic hepatitis between January 1, 1999 and December 31, 2004 at Hanyang University Guri-Hospital were analyzed retrospectively. Results: Of the 138 medical records reviewed, 74 cases fulfilled the inclusion criteria (61 males and 13 females; mean age 47.1 years). Twelve patients (16.2%) died within 90 days after admission. Univariate analysis demonstrated that variables such as ascites, hepatic encephalopathy, splenomegaly, international normalized ratio, CTP, and DF scores were significantly correlated with increased 90-day mortality while MELD score was not. According to the multivariate analysis, only CTP score was statistically significant (p=0.012) while DF and MELD scores were not significant for predicting 90-day mortality. The survival analysis with Cox regression test showed higher DF and CTP scores, but not MELD score, significantly increased the risk of in-hospital mortality. Conclusions: This study demonstrates that DF and CTP scores are independent predictors of short-term mortality in patients with alcoholic hepatitis. (Korean J Gastroenterol 2007;49:93-99)
전신성 홍반성 루푸스 신염 활성도와 소변 Transforming Growth Factor-β Induced Gene-h3 (βig-h3)의 연관성
김일 ( Il Kim ),홍철호 ( Cheol Ho Hong ),조현석 ( Hyun Seok Cho ),유선진 ( Sun Jin You ),백창희 ( Chang Hee Paik ),이혜순 ( Hye Soon Lee ),엄완식 ( Wan Sik Uhm ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),유대현 ( Dae Hyun Yo 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.4
Background: TGF-β-induced gene-h3 (βig-h3) is a novel gene induced by active TGF-β and the association with other renal disease is reported. Lupus nephritis is characterized by excessive extracelluar matrix accumulation and the implication that TGF-β is increased in lupus nephritis is known. We measured the urinary βig-h3 in lupus nephritis and sought its association with the activity of lupus nephritis through renal biopsy. The objective of this study was to examine urinary βig-h3 excretion in lupus nephritis and the association with activity of lupus nephritis. Methods: Fifteen patients (median age 32.6±2.9 years, range 18∼64) who developed lupus nephritis underwent renal biopsy. At the time of biopsy, they showed significant proteinuria. Total urinary βig-h3 concentration was assayed by enzyme-linked immunoabsorbent assay and expressed as a ratio to urinary creatinine concentration. Results: There were correlations between urinary βig-h3 and the reduction of C3 (r=-0.566, p=0.028<0.05), the magnitude of proteinuria (r=0.531, p=0.042<0.05). The Activity Index, Chronicity Index in the renal biopsy, C4, anti-dsDNA Ab titer were not significantly correlated with urinary βig-h3 excretion, but the patients with high Activity Index had the increased level of urinary βig-h3. Five patients who had fibrinoid necrosis in renal biopsy showed higher level of urinary βig-h3 than the others (107.78±43.02 vs. 50.21±10.12 ng/ml, p=0.061) Conclusion: In this study, There is some correlation between urinary βig-h3 and the activity of lupus nephritis. Urinary βig-h3 may play a role in predicting the active lupus nephritis. A further study is needed in large population and in situ expression of βig-h3.
이준수,변재원,최일영,오호석,백창희,정성진,최정혜,안명주,이영열,김인순,이웅수,김신규 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.2
Chronic lymphocytic leukemia(CLL) is a neoplastic disease characterized by the accumulation of small mature-appearing lymphocytes in the blood, bone marrow, lymph nodes, and spleen, resulting in enlargement of the lymph nodes and spleen, and decreased bone marrow function. CLL has an average incidence of 30 percent of all leukemia cases in Western countries, but it is extremely rare in Asia. T cell origin (T-CLL) is a very rare CLL subtype, as ninety five percent of CLL have B-cell markers. It has an aggressive clinical course. We have experienced a case of T4-CLL, which was confirmed by immunophenotyping panel. A 54-year-old male was admitted for abdominal distension which persisted for one month. A physical examination showed 5 finger sized splenomegaly and cervical lymphadenopathy on both side. The white blood cell count was 131,000/(L with 82% morphologically mature lymphcoytes with many smudge cells. A bone marrow aspirate revealed 61% lymphocytes morphologically similar to peripheral lymphocytes, which were small with a high nuclear cytoplasmic ratio and round to oval nuclei with absent or small inconspicuous nucleoli. The immunophenotyping study of lymphcoytes revealed phenotype of CD3(+), CD4(+), but CD8(-), CD19(-), CD20(-).