재발성 아프타성 구내염에서 Methylenetetrahydrofolate 환원효소 유전자 C677T 변이와 Apolipoprotein E 유전자 변이에 대한 연구

백진옥 ( Jin Ok Baek ),김민 ( Min Kim ),임정수 ( Jung Su Im ),윤성태 ( Sung Tae Youn ),노주영 ( Joo Young Roh ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.2

Background: Recurrent aphthous stomatitis (RAS) is usually the earliest sign of Behcet`s disease. Hyperhomocysteinemia can damage endothelial cells and progress to obstructive vascular disease. It has been reported that hyperhomocysteinemia is a marker of activation in Behcet`s disease. Enzyme 5,10-methylenetetrahydrofolate reductase may be one of the main factors that regulates plasma homocysteine levels. Homozygosity for the C677T (MTHFR C677T) mutation is associated with reduced activity of this enzyme and considered the most common genetic cause of elevated serum homocyteine levels. However its relationship to vascular injury in Behcet``s disease remains controversial, and its relationship to RAS is unknown. Apolipoprotein E (Apo E) has both immunoregulatory and anti-infective features. Search for Apo E polymorphism and lipid composition in RAS patients might be a clue to pathogenesis of RAS. Objective: To analyze the relationship of MTHFR gene C677T polymorphism, several epidemiologic factors such as age and sex, smoking, lipid composition and Apo E polymorphism to vasculitis in RAS, we assessed the MTHFR gene C677T polymorphism, Apo E polymorphism and lipid composition in RAS and normal population. Methods: We analyzed data from the General Health survey conducted on 1,243 participants (M:F=281:962) over a 20 year-old in Incheon city. Medical interview and laboratory test for methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, apolipoprotein E polymorphism were completed. Statistical significance was analyzed by χ2 test and multistep logistic regression analysis. Results: Among normal population over the age of twenty, a total of 34.2% (426/1,243) had RAS. Female predominance (4.5:1, p=0.003) was noted. The incidence of RAS in age group 20 to 39 year old is higher than the over 40 age group. The incidence is higher in smoking group compared to the nonsmoking group in multistepwise logistic regression analysis. Frequency of the MTHFR C677T genotypes was highest at CT compared to CC and TT homozygous genotype in normal and RAS patients group. There was no significant statistical differences in MTHFR genotypes in RAS patients compared to the control group. Similarly, Apo E genotype analysis revealed no significant statistical differences either. Apo E genotype and total cholesterol, HDL-cholesterol, triglyceride level didn`t show any associations. Conclusion: This study revealed insignificant association between the MTHFR C677T mutation and RAS. Apo E genotype didn`t show a significant statistical difference in RAS patients compared to normal controls. (Korean J Dermatol 2008;46(2):209∼215)

백모증과 동반된 미만성 신경섬유종

백진옥 ( Jin Ok Baek ),이혜영 ( Hye Young Lee ),김민 ( Min Kim ),노주영 ( Joo Young Roh ),이종록 ( Jong Rok Lee ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.8

A 37-year-old man presented with a 1-year history of asymptomatic ill-defined subcutaneous thickening with overlying whitish hairs on right occipital scalp. Histopathologic examination from this subcutaneous mass revealed neurofibromatous tissue with a diffuse infiltrative growth. S-100 protein staining showed decreased melanocytes and melanin in hair follicles. He was diagnosed as a diffuse neurofibroma associated with poliosis. To our knowledge, only two cases of poliosis associated with neurofibroma have ever been reported in English. (Korean J Dermatol 2007;45(8):811∼813)

청소년의 자기애 성향과 내재화,외현화 문제의 관계

백진옥(Jin Ok Baek),염시창(Si Chang Yum) 전남대학교 교육문제연구소 2007 교육연구 Vol.30 No.-

Educational Lecture 1-3 (EL 1-3) : Patch test

백진옥 ( Jin Ok Baek ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Patch test is used for diagnosis and identifying causes of contact dermatitis. Together with a detailed clinical history and physical examination, it is the most important and strong method to investigate contact hypersensitivity. It is based upon that primed antigen-specific T lymphocytes in sensitized individuals are ready to recreate a delayed type hypersensitivity reaction when the antigen are applied to normal skin again. Patch test is indicated when an allergic component of the dermatitis is suspected, and may also be used adjunctively to determine the presence of a contact hypersensitivity component in other chronic dermatologic diseases, such as atopic dermatitis, seborrheic dermatitis, dyshidrotic eczema, psoriasis, drug eruption. Contraindications for patch testing include immune deficiencies, immunosuppressive treatment (drugs, sunbathing, sunbeds), and autoimmune diseases. Pregnancy and lactation are other contraindications. In a typical patch test protocol, certain amounts of suspected allergens are applied onto the skin for 48 hours, and the subsequent assessment of skin reaction is done at defined time points, typically after 2 and 4 days. The most widely used patch test application systems are traditional round aluminium Finn Chambers (Epitest), squaric IQ Ultra Chambers made of soft polyethylene foam (Chemotechnique Diagnostics), and TRUE Test (Thin-layer Rapid Use Epicutaneous Test). Test substances should be chosen accordingly to clinical history. "Standard series" are collections of substances that are the most frequent sensitizers in the population of a given geographical area like European Baseline Series (EBS), North American Series (NAS), the International Standard Series (ISS). We have Korean Standard Series. There are other series for groups of specific exposure (occupational or lifestyle) such as cosmetic, sunscreen, dental, epoxy resin, medicament. The reading and interpretation of patch results requires training and some experience. Interpretation of reaction sites is based on the method recommended by the International Contact Dermatitis Research Group (ICDRG). A grading scale from 1+ to 3+ is currently accepted for ranking these allergic reactions. The clinical relevance of positive patch test should be considered in each case. The specificity and sensitivity of patch tests is typically about 80%. There are possible adverse effects including a recall on active dermatitis, generalization of ACD (angry back syndrome), irritation of the skin by adhesive material, local site reaction such as postinflammatory pigmentation disorders, scarring, milia and rarely contact urticaria and anaphylaxis.

Changes in microbiota of oral tolerance-induced atopic dermatitis mouse model

백진옥 ( Jin Ok Baek ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

장미색 비강진 환자에서 경구 Famciclovir 투여의 효과

백진옥 ( Jin Ok Baek ),김민 ( Min Kim ),노주영 ( Joo Young Roh ),이종록 ( Jong Rok Lee ),이애영 ( Ai Young Lee ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.12

Background: Pityriasis rosea is a common, acute self-limiting papulosquamous disorder in which many studies suggest viral causative factors in its pathogenesis. Recently, the link between pityriasis rosea and the reactivation of human herpes virus-6 (HHV-6) and HHV-7 infection has been suggested. This evidence suggests that targetting HHV-6 or HHV-7 may be an effective treatment for pityriasis rosea. Objective: We treated pityriasis rosea patients with oral famciclovir to investigate the effect of oral famciclovir in pityriasis rosea. Methods: A case group of seventeen patients with pityriasis rosea were treated with oral famciclovir (250 mg 3 times daily for 7 days). Clinical evaluation at 0, 1 & 2 weeks was undertaken. A skin biopsy and polymerase chain reaction analysis of HHV-6 from a skin specimen were performed. We analyzed 19 patients with pityriasis rosea who were treated with topical steroid and oral antihistamines retrospectively and considered them as the control group. Results: On the 7th day after oral famciclovir treatment was started, pityriasis rosea had regressed completely in 3 patients (17.6%) and had regressed partially in 9 patients (52.9%). On the 14th day, 12 patients (70.6%) had achieved more than partial regression. On the 7th day, systemic symptoms had improved in all 9 patients. Clearance of skin lesions was achieved in average 7.57 days in patients who had regressed completely after 14 days` treatment. Histological examination of patients was compatible with pityriasis rosea and polymerase chain reaction analysis of HHV-6 was negative in all 8 patients. Compared with the control group, the treatment for patients in the case group seemed to have better effects, but statistical analysis failed to show any significant differences between the two groups. Conclusion: Famciclovir was not effective in the treatment of pityriasis rosea, but further investigation is needed. (Korean J Dermatol 2007;45(12):1240∼1245)

Hydroxychloroquine으로 치료한 Rosai-Dorfman병

백진옥 ( Jin Ok Baek ),이혜영 ( Hye Young Lee ),이종록 ( Jong Rok Lee ),김민 ( Min Kim ),노주영 ( Joo Young Roh ),김유찬 ( You Chan Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.10

Rosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy (SMHL) is a benign histiocytic proliferative disorder of unknown etiology. It is accompanied by fever, leukocytosis, elevated erythrocyte sedimentation rate and polyclonal hypergammaglobulinemia. Histopathologic examinations showed characteristic large histiocytes exhibiting emperipolesis. On immunohistochemical stains, histiocytes are positive for CD68 and S-100 protein, but negative for CD1a. The lymph node involvement is typical, but it may also involve other systemic organs in one third of cases such as skin, upper respiratory tract, bone and so on. Patients with purely cutaneous Rosai-Dorfman disease are of older age at onset of the disease with a reversed male/female ratio, so cutaneous Rosai-Dorfman disease is recognized as a distinct entity from Rosai-Dorfman disease. We present a 48-year-old woman with an asymptomatic erythematous indurated plaque with yellowish papules on her left cheek and erythematous papules on her left infraorbital area, diagnosed as cutaneous Rosai-Dorfman disease at first. But 3 months later, she developed a palpable lymph node on her left submandibular area. She responded to high-dose hydroxychloroquine treatment. (Korean J Dermatol 2007;45(10):1055∼1059)

Aging and the Skin Barrier Function

백진옥 ( Jin Ok Baek ) 한국피부장벽학회 2017 한국피부장벽학회지 Vol.19 No.1

Despite age-related changes in skin appearance are well documented, less is known about changes of the skin barrier function during aging. Several markers of skin barrier function such as transepidermal water loss, stratum corneum hydration, sebum secretion and pH value were used to reveal these changes, but the influence aging on skin barrier function is still controversial. Some studies present an impairment of the skin barrier function with aging, while others show no significant changes. In this review, we discuss an age-related alteration and associating factors of barrier function.

Recent updates in skin barrier research

백진옥 ( Jin Ok Baek ) 한국피부장벽학회 2022 한국피부장벽학회지 Vol.24 No.1

최근의 피부 장벽 연구는 장벽 기능 약화와 관련된 인자들의 규명, 장벽 기능 향상을 위한 유효 물질 발굴과 검증, 장벽 이상이 있는 질환에서의 다양한 치료적 시도 등의 경향을 보이고 있다. 최근 2년간의 피부 장벽 관련 논문들 중 장벽 기능 약화와 관련해서는 유아기 알레르기 감작, 손소독제, 코로나바이러스, 물에 대한 연구가 있었으며 장벽 기능 향상 물질로 Baicalin (황금), cycloastragenol (황기), 화산광천수, 한국토종식물오일, Ectoine 등이 검증되었다. 장벽 이상을 동반하는 대표적 질환인 아토피 피부염의 완화를 위한 보습제 사용에 대해서도 지속적 연구가 이루어지고 있었고, 피부 박테리아나 마이크로 바이옴과 장벽에 관한 연구들도 발표되었다.

최근 일반 건강인에서의 매독 유병률 경향: 서울지역 단일 기관에서의 연구

백진옥 ( Jin Ok Baek ),지현중 ( Hyun Joong Jee ),김태균 ( Tae Kyun Kim ),김현숙 ( Hyun Sook Kim ),이민걸 ( Min Geol Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.2

Background: Due to effective medicine and improved socioeconomic status, the prevalence of syphilis has rapidly decreased in South Korea. We have reported the prevalence of syphilis periodically in our center since 1977, using the same geographical areas and similar population groups and methods in order to determine trends. Objective: To determine the current prevalence of syphilis in the healthy population of Korea and trends of syphilis prevalence during the last 30 years. Methods: Venereal Disease Reserch Laboratory (VDRL) tests were administered to 12,453 healthy adults aged 20 or greater (12,013 physical examinees, 440 pregnant women) examined at Severance Hospital between January and December of 2005. We carried out VDRL quantitative tests and FTA-ABS tests in VDRL-reactive persons. The results were compared with that of 6 previous surveys in similar population groups reported by the same authors. Statistical analysis of the data was conducted using the Statistical Analysis System (SAS version 9.1, SAS Institute Inc., Cary, NC, USA). Results: The total number of subjects positive on the VDRL test was 83 of 12,453 (0.7%). A VDRL-positive rate of 0.2% was found among the 440 pregnant women, while the 12,013 physical examinees showed a positive rate of 0.7%. Among all age groups, the VDRL-positive rate exhibited a decreasing trend from 1977 to 2005 (p<0.0001). Although there is a difference between 2000 and 2005, which indicates an increase in prevalence in those surveyed as a whole, the increase is not significant when analyzed by age groups. Conclusion: During the last thirty-years, the prevalence of syphilis has decreased. But, in our survey of 2005, we found an increase in prevalence. Further evaluation is necessary to confirm the trend towards an increase and the causes of the increase. Moreover, extensive policies and strategies including prophylaxis, management, education of syphilis are needed. (Korean J Dermatol 2011; 49(2):106~110)