매독환자의 혈청내 면역복합체에 관한 연구

이민걸,곽호,박주영,김세종,이정복 ( Min Geol Lee,Ho Kwahck,Joo Young Park,Se Jong Kim,Jung Bock Lee ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.4

Circulating immune Complex in Syphilis Min Geol Lee, M.D., Ho Kwahck, M.D., Joo Young Park, M.D.*, Se Jong Kim, M.D.*, Jung Bock Lee, M.D. Departments of Dermatology, Microbiology* Yonsei University College of Medicine, Seoul, Korea In this study, the author tried to clarify the relationships between the clinical stages of untreated syphilis and the positive rates of circalating immune complex(CIC). Additionally, the study looks at the duration of CIC conversion to negative in the treated previously positive patient by means of solid phase CIq enzyme assay(CIq EA), solid phase anti-CIq enzyme assay (anti-Ciq EA), and platelet aggregation test(PAT)to get the following results. The results are as follows : 1. Among the 132 untreated patients, 36 patients(27.3%) were CIC positive in at least one of the three tests performed, and in the negative groups, two out of 50(4.0%) were CIC positive. 2. The positive rates beginning with the highest were as follows : secondary syphilis, early latent syphilis, late latent syphilis, and primary syphilis. 3. Among the seven CIq EA positive patients before treatment, two had negative conversion in the first week after treatment. Among the remaining five, one remained positive after three weeks and four after three months. 4. Among the six anti-CIq EA positive patients before treatment, there were three negative conversions after two weeks, one after three months ; the remaining two stayed positive. 5. The one PAT positive patient showed negative coversion after one week of treatment.

아시아-태평양 의학교육 동향

이민걸,김경섭,정현주,신전수,양은배,신홍임,Lee, Min-Geol,Kim, Gyeong-Seop,Jeong, Hyeon-Ju,Sin, Jeon-Su,Yang, Eun-Bae,Sin, Hong-Im 연세대학교 의과대학 2007 의학교육논단 Vol.9 No.1

조기 매독환자에서 Penicillin 치료전과 치료후의 Treponerma pallidum에 특이한 IM 항체의 변화

이민걸,Ferdinand Muller (Min Geol Lee) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.6

1기 매독과 2기 매독 그리고 조기 잠복 매독환자 142명에서 페니실린 치료 전과 치료 후, 매독균에 특이한 IgM항체의 변화를 정량적으로 관찰하였다. 치료 전 이들 환자의 IgM항체는 매독의 임상기와 상관없이 1:20~≥1,280이었다. 페니실린 치료 후 IgM항체는 1기 매독환자 모두에서 9개월이내에 완전 소실되었고, 2기 매독환자의 25%와 조기 잠복매독 환자의 35%에서는 9개월 이후까지 지속되었으나 이들 환자에서도 치료후 19개월까지 IgM항체가 소실되었다. 그리고 이러한 매독균에 특이한 IgM항체의 생성과 치료후의 소실에 관여하는 면역학적 기전에 관하여도 살펴보고자 한다. N/A

매독균에 특이한 단세포군 항체의 이용에 관한 연구

이민걸,황규광,이정복 ( Min Geol Lee,Kyu Kwang Hwang,Jung Bock Lee ) 대한피부과학회 1990 大韓皮膚科學會誌 Vol.28 No.6

매독 환자의 병변에서 Avidin - Biotin - Peroxidase Complex법을 이용한 Treponema pallidum 검출에 관한 연구

이민걸(Min Geol Lee),이원수(Won Soo Lee),이정복(Jung Bock Lee) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.1

Using the avidin-biotin-peroxidase complex(ABC) technique, 36 skin specimens from 30 patients with primary and secondary syphilis and a gastric mucosal specimen from a patient with secondary syphilis which were confirmed by clinical history, physical examination, the VDRL, FTA-ABS, TPHA, and 19s(IgM)-FTA test, were examined. The results were compared with that of the indirect mmunoperoxidase technique which was done by authors previously with same specimens. The following results were obtained. 1. Of the 37 specimens, 35(95%) were positive in ABC technique and 33 of the 37 specirnens(89%) were positive in the indirect immunoperoxidase technique. 2. The ratio of agreement of the results between the ABC and the indirect immunoperoxidase technique was 89%. 3. Most of the treponemes were located in the upper dermis, epidermis, and blood vessel walls in the arder named, and rarely in the lower dermis of the syphilitic skin lesions. There was no remarkable difference in histologic distribution of treponemes between the clinical stages and types of syphilitic skin lesions. :From the results, the ABC technique is considered to be an excellent method for detecting the treponemes in the suspected syphilitic lesions.

경부 가성 피부위축증

이민걸(Min Geol Lee),황규광(Kyu Kwang Whang),김동건(Dong Kun Kim) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.4

Pseudoatrophoderma colli is a symptomless, persistent, persistent, pigmentary disorder involving the neck and upper thorax first described by Becker and Muir in. 1934 The lesion is usually localized to the neck and upper part of the thorax. It consists of macules or papules which show pigmentation or papules which show pigmentation or depigmentation and look atrophic. Histological examination shows hyperkeratosis, hypogranulosis, focal acanthosis and perivascular lymphocytic infiltration. We present herein a case of pseudoatrophoderma colli which showed symptomless, mottled, pigmentated macules involving the neck clinically and compatible findings histopathologically.

매독환자의 혈청 IgM 항체에 반응하는 매독균 단백항원에 관한 연구

이민걸(Min Geol Lee),성열오(Yeol Oh Sung),김동건(Dong Kun Kim),이정복(Jung Bock Lee) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.4

This study was undertaken to identify the protein antigens reacting with IgM antibodies in the sera of various stages of syphilis before and after treatment, employing sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting and immunoperoxidase stain. The results were as follows : 1. Before treatment, the most strongly reacting antigens of T. pallidam precipitated by IgM antibodies in the sera of patients were polypeptides of molecular weights 47,000, 34,000 and 29,500. So it was observed that those were the major antigens of T. pallidum reacting with IgM antibodies. 2. After observing protein antigens of T. pallidum reacting with IgM antibodies in the sera of patients with syphilis before and after treatment, it was seen that in primary, secondary and early latent syphilis there was a loss of several antigens and s decrease in reactivity, but no changes occurred in late latent and reinfected syphilis. 3. From the observation of the reaction between serum antibodies of patients with trested syphilis and major antigens of T. pallidum, an evident decrease in reactivity was observed only with protein antigen of molecular weight 47,000 which reacts with IgM antibody. From the above results, it could be concluded that of molecular weight 47,000 could contribute to the assessment of the diagnosis of syphilis and the efficacy of treatment.

1기 매독 병변을 공유한 2기 매독 3예

이민걸(Min Geol Lee),김형주(Hyung Joo Kim),이정복(Jung Bock Lee) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.1

We present herein 3 cases of early secondary syphilis with simultaneous primary syphilitic lesions. These cases developed primary syphilitic lesions four to six weeks after sexual contact and lasted six to ten weeks thereafter until the secondary syphilitic lesions appeared. All three patients showed a strong positive for the STS. Spirochetes were seen under dark field examination of the primary syphilitic lesions, Histopathologically, numerous plasma cells around capillaries and endothelial hyperplasia were seen in the dermis.

전자현미경으로 바이러스 입자를 관찰한 재발성 대상 포진으로 추정되는 2예

이민걸(Min Geol Lee),이은소(Eun So Lee),남인환(In Whan Nam),이성낙(Sung Nack Lee) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.4

Herpes zoster is known to recur only rarely. However reports on the recurrence rates by various authors ranges from 0.l% to 8%. We have experienced 2 cases of recurrent herpes zoster in a 63-year-old female and a 62-year-old male who presented with typical clinical features and previous history of herpes zoster. They were suffering from breast cancer and Hodgkin's disease, respectively. By employing negative and positive staining methods of electron microscopy, typical herpes viral particles were demonstrated from the vesicular fluid.

섬모기질종양 변화를 동반한 표피 낭종

이민걸(Min Geol Lee),이원수(Won Soo Lee),전수일(Soo Il Chun),한충섭(Choong Seop Hahn) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.1

We reported a case of subcutaneous mass in a 22-year-old lady having unusual histopathologic findings mixed with both features of pilomatricoma and epidermal cyst and the meanings of these peculiar findings were discussed.