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RISS 인기검색어
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- 저자 : 이민걸 ( Min Geol Lee ) (검색결과 94 건)
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조기 매독환자에서 Penicillin 치료전과 치료후의 Treponerma pallidum에 특이한 IM 항체의 변화
이민걸,Ferdinand Muller (Min Geol Lee) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.6
1기 매독과 2기 매독 그리고 조기 잠복 매독환자 142명에서 페니실린 치료 전과 치료 후, 매독균에 특이한 IgM항체의 변화를 정량적으로 관찰하였다. 치료 전 이들 환자의 IgM항체는 매독의 임상기와 상관없이 1:20~≥1,280이었다. 페니실린 치료 후 IgM항체는 1기 매독환자 모두에서 9개월이내에 완전 소실되었고, 2기 매독환자의 25%와 조기 잠복매독 환자의 35%에서는 9개월 이후까지 지속되었으나 이들 환자에서도 치료후 19개월까지 IgM항체가 소실되었다. 그리고 이러한 매독균에 특이한 IgM항체의 생성과 치료후의 소실에 관여하는 면역학적 기전에 관하여도 살펴보고자 한다. N/A
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이민걸 ( Min Geol Lee ),곽호 ( Ho Kwahck ),박주영 ( Joo Young Park ),김세종 ( Se Jong Kim ),이정복 ( Jung Bock Lee ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.4
Circulating immune Complex in Syphilis Min Geol Lee, M.D., Ho Kwahck, M.D., Joo Young Park, M.D.*, Se Jong Kim, M.D.*, Jung Bock Lee, M.D. Departments of Dermatology, Microbiology* Yonsei University College of Medicine, Seoul, Korea In this study, the author tried to clarify the relationships between the clinical stages of untreated syphilis and the positive rates of circalating immune complex(CIC). Additionally, the study looks at the duration of CIC conversion to negative in the treated previously positive patient by means of solid phase CIq enzyme assay(CIq EA), solid phase anti-CIq enzyme assay (anti-Ciq EA), and platelet aggregation test(PAT)to get the following results. The results are as follows : 1. Among the 132 untreated patients, 36 patients(27.3%) were CIC positive in at least one of the three tests performed, and in the negative groups, two out of 50(4.0%) were CIC positive. 2. The positive rates beginning with the highest were as follows : secondary syphilis, early latent syphilis, late latent syphilis, and primary syphilis. 3. Among the seven CIq EA positive patients before treatment, two had negative conversion in the first week after treatment. Among the remaining five, one remained positive after three weeks and four after three months. 4. Among the six anti-CIq EA positive patients before treatment, there were three negative conversions after two weeks, one after three months ; the remaining two stayed positive. 5. The one PAT positive patient showed negative coversion after one week of treatment.
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매독환자의 혈청 IgM 항체에 반응하는 매독균 단백항원에 관한 연구
이민걸(Min Geol Lee),성열오(Yeol Oh Sung),김동건(Dong Kun Kim),이정복(Jung Bock Lee) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.4
This study was undertaken to identify the protein antigens reacting with IgM antibodies in the sera of various stages of syphilis before and after treatment, employing sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting and immunoperoxidase stain. The results were as follows : 1. Before treatment, the most strongly reacting antigens of T. pallidam precipitated by IgM antibodies in the sera of patients were polypeptides of molecular weights 47,000, 34,000 and 29,500. So it was observed that those were the major antigens of T. pallidum reacting with IgM antibodies. 2. After observing protein antigens of T. pallidum reacting with IgM antibodies in the sera of patients with syphilis before and after treatment, it was seen that in primary, secondary and early latent syphilis there was a loss of several antigens and s decrease in reactivity, but no changes occurred in late latent and reinfected syphilis. 3. From the observation of the reaction between serum antibodies of patients with trested syphilis and major antigens of T. pallidum, an evident decrease in reactivity was observed only with protein antigen of molecular weight 47,000 which reacts with IgM antibody. From the above results, it could be concluded that of molecular weight 47,000 could contribute to the assessment of the diagnosis of syphilis and the efficacy of treatment.
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이민걸(Min Geol Lee),김양안(Yang An Kim),이성낙(Sung Nack Lee) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.1
An 8-year-old female has suffered from intense burning with redness and increased temperature of the feet and hands since 5-year-old. We observed increase of the skin temperature in relation of pain attack by the digital thermometer and the color television thermography. No specific abnormalities were noted in the laboratory studies. Treatment with various systemic and topical medication revealed of unfavorable result, but for the conservative mangement, the pain was relieved by the exposure to the cold environment-laying bare in the outdoors and the wind of the electric fan.
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Focus 2-5 (FS 2-5) : Skin manifestations of other AIDs
이민걸 ( Min Geol Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Monogenic autoinflammatory syndromes (MAISs) are caused by innate immune system dysregulation leading to aberrant inflammasome activation and episodes of fever and involvement of skin, serous membranes, eyes, joints, gastrointestinal tract, and nervous system, predominantly with a childhood onset. To date, the autoinflammatory diseases can be grouped based on clinical findings: 1. the three classic hereditary “periodic fever syndromes”, familial Mediterranean fever (FMF); TNF receptor associated periodic syndrome (TRAPS); and mevalonate kinase deficiency/hyperimmunoglobulinemia D and periodic fever syndrome (HIDS); 2. the cryopyrin associated periodic syndromes (CAPS), comprising familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and neonatal-onset multisystem inflammatory disease (NOMID) or CINCA, and; 3. pediatric granulomatous arthritis (PGA); 4. disorders presenting with skin pustules, including deficiency of interleukin 1 receptor antagonist (DIRA); Majeed syndrome; pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome; deficiency of interleukin 36 receptor antagonist (DITRA); CARD14 mediated psoriasis (CAMPS), and early-onset inflammatory bowel diseases (EO-IBD); 5. inflammatory disorders caused by mutations in proteasome components, the proteasome associated autoinflammatory syndromes (PRAAS) and 6. very rare conditions presenting with autoinflammation and immunodeficiency. The purpose of this lecture is to describe the main genetic, clinical, and therapeutic aspects of several MAISs not as famous as PAPA (Pyogenic Arthritis, Pyoderma gangrenosum, Acne) in the field of dermatology, with the ultimate goal of increasing awareness of autoinflammation among dermatologists. This lecture will mainly cover 1. DIRA (deficiency in IL-1 receptor antagonist / MIM 612852) 2. TRAPS (TNF-α-associated periodic syndrome / MIM 191190) 3. HIDS (hyperimmunoglobulinemia D syndrome / MIM 260920) 4. Cryopyrinopathies: CAPS (Cryopyrin-associated periodic syndrome): 1) familial cold urticaria: FCAS (MIM 120100) 2) MWS (MIM 191900) 3) NOMID (MIM 607115).
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