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한창규,황규윤안규동,이병국 순천향대학교 산업의학연구소 1996 순천향산업의학 Vol.2 No.1
To obtain the prevalence rate of health related symptoms of white collar workers who were not exposed to hazardous agent and to investigate the relationship between subjective symptoms & health related variables, 11,266 subjects who were employed for government organization & private educational institute in Seoul, Chungnam, Kyungpook area were studied in order to provide basic information for the health management of white collar workers. All th subjects visited hospitals to take biannual health examination provided Medical Insurance Association for the purpose of screening of several important adult disease. Todai Health Index(THI) questionnaire which is modified questionnaire of CMI made by Todai was selected for the questionnaire form of this study. During hospital visit for health examination, Todai Health Index questionnaire of 88 questions were filled up by the subjects themselves and confirmed by medical doctor. Major findings obtained were as follows: 1. The abnormal rate of screening test was 22.7% in male, 8.5% in female, and 19.2% in total subjects. The prevalence rate of disease was 13.2% in male, 4.9% in female & 10.9% in total subjects. 2. The prevalence rate of all diseases increased by age and th prevalence rate of male subjects were higher than female subjects in all age categories except that of the anemic disease. 3. While highest prevalence rate in all subjects was observed in cardiovascular disease(4.8%), the prevalence rate were 3.4% in liver disease, 2.0% in diabetic disease, 1.9% in pulmonary tuberculosis & chest disease, 0.5% in kidney disease and 0.4% anemic disease. Liver disease was more frequent in age group of below 29 years old and age group of 30-39 years old, but in older age groups(40-49 years old, above 50 years), cardiovascular disease was most frequent. 4. The highest mean score of THI symptom category was mental instability and the lowest one was skin & anus symptoms. The most frequent symptom of THI was "think a lot before action" in nervousness symptom category and mean scores of the female subjects in all symptom category were higher that those of male subjects. 5. In symptoms and signs of recent 3 months, the most frequent symptom and sign was "generalized fatigue" and mean score of it was 1.85. Multiple comparison analysis of health related factors revealed that "illness in health status" was the highest score(23.54) in male and sometimes drink & drunken in alcohol intake was th highest score(26.13) in female. 6. In multiple comparison analysis, health related factors such as health status, health management, diet habit, taste character, vegetable intake, coffee & beverage, alcohol intake were found to be associated with th overall THI symptom category in both sex and age and smoking in male, type of job in female were associated THI symptom category. 7. In stepwise multiple regression analysis of mean score of THI symptom category(dependent variable) and health related factors(independent variables), the variables of health health status, taste character and alcohol were contributed to THI symptom category in order and the highest correlation coefficient(r) was 0.4085 in male and 0.397 in female in health status of mental instability. 8. The significant health factors contribution to THI symptoms score in male subjects were, in multiple regression analysis with THI symptom category with dependent variable and health related factors with independent variables, health status, diet habit, alcohol intake, taste character, final diagnosis, coffe & beverage, type of job, age, smoking, health management, meat intake and in female were health status, type of job, diet habit alcohol intake, coffee & beverage consumption, screening test, age, health management. The most significant contribution factor among health related variables was health status in over all THI symptom category.
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한창규,한재경,박기범,곽경화,박성식,임동건 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.63 No.2
Background: Reactive oxygen species and inflammatory responses contribute to the development of neuropathic pain. Superoxide serves to mediate cell signaling processes and tissue injury during inflammation. We examined the effects of superoxide on the development and maintenance of mechanical allodynia, as well as its contribution to central sensitization in a superoxide-rich animal model of neuropathic pain. Methods: Chronic post-ischemia pain (CPIP) was induced via the left hindpaw ischemia for 3 h, followed by reperfusion. Superoxide dismutase (4,000 U/kg, i.p.) was administered either 5 min before ischemia (BI), 5 min before reperfusion (BR), or 3 days after reperfusion (3AR). Withdrawal thresholds of the four paws were measured to assess the mechanical allodynia and the effects of circulating xanthine oxidase (XO)-mediated superoxide production. In addition, we measured the levels of N-methyl D-aspartate receptor subunit 1 phosphorylation (p-NR1) in the ipsilateral and contralateral spinal cord (L4-6), by Western blotting, to examine the superoxide-mediated central sensitization. Superoxide production was assessed by allopurinol-sensitive, XO-mediated lipid peroxidation of the spinal cord and gastrocnemius muscles. Results: Withdrawal thresholds of forepaws did not vary across the 7 days of testing. In the hindpaws, both ipsilateral and contralateral mechanical allodynia was most attenuated in the BR group, followed by the BI and 3AR groups. The degree of NR1 activation was in contrast to the changes in the withdrawal thresholds. Conclusions: These data suggest that superoxide is involved in the development and maintenance of mechanical allodynia, particularly via central sensitization in the spinal cord. Background: Reactive oxygen species and inflammatory responses contribute to the development of neuropathic pain. Superoxide serves to mediate cell signaling processes and tissue injury during inflammation. We examined the effects of superoxide on the development and maintenance of mechanical allodynia, as well as its contribution to central sensitization in a superoxide-rich animal model of neuropathic pain. Methods: Chronic post-ischemia pain (CPIP) was induced via the left hindpaw ischemia for 3 h, followed by reperfusion. Superoxide dismutase (4,000 U/kg, i.p.) was administered either 5 min before ischemia (BI), 5 min before reperfusion (BR), or 3 days after reperfusion (3AR). Withdrawal thresholds of the four paws were measured to assess the mechanical allodynia and the effects of circulating xanthine oxidase (XO)-mediated superoxide production. In addition, we measured the levels of N-methyl D-aspartate receptor subunit 1 phosphorylation (p-NR1) in the ipsilateral and contralateral spinal cord (L4-6), by Western blotting, to examine the superoxide-mediated central sensitization. Superoxide production was assessed by allopurinol-sensitive, XO-mediated lipid peroxidation of the spinal cord and gastrocnemius muscles. Results: Withdrawal thresholds of forepaws did not vary across the 7 days of testing. In the hindpaws, both ipsilateral and contralateral mechanical allodynia was most attenuated in the BR group, followed by the BI and 3AR groups. The degree of NR1 activation was in contrast to the changes in the withdrawal thresholds. Conclusions: These data suggest that superoxide is involved in the development and maintenance of mechanical allodynia, particularly via central sensitization in the spinal cord.
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엔드밀 형상에 따른 가공특성 분석을 이용한 형상설계 S/W 개발
한창규,고성림,유중학,서천석,김경배 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-
The tool geometry parameters and cutting process have complex relationships. Until now, various cutting test were needed to acquire optimal design of end mill for the purpose of high speed machining, due to the insufficient knowledge about cutting process in high speed machining. Using various tools with different geometry, relationships between tool geometry parameter (rake angle, clearance angle, length of cutter) and cutting process (cutting force, surface accuracy, surface roughness) have been studied. Acquired data can be used to design optimal tool for high speed machining and developed tool geometry design S/W.
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