http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
폴리에틸렌옥시드를 이용한 캅토프릴 매트릭스 정제의 제조 및 약물동력학적 평가
장혁,백명기,지웅길,Jiang, Ge,Baek, Myoung-Ki,Jee, Ung-Kil 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.1
The captopril matrix tablets composed of polyethylene oxide(PEO) was prepared and administered to beagle dogs. Captopril matrix tablets were prepared using direct compressed method and wet granulation compressed method with various ratios of drug to PEO. The diffusion rate of captopril matrix tablets followed on the Higuchi's diffusion model. With increasing hardness of captopril matrix tablets, release rate was decreased. Each formulation was evaluated by the area under the curve (AUC) and time course of plasma captopril concentration after oral administration to beagle dogs. The $AUC_{0-12}$ were $9.126\;{\mu}g\;h/ml$ and $6.417\;{\mu}g\;h/ml$ for the matrix tablets and conventional tablets, respectively. Therefore, the bioavailability of captopril matrix tablets was greater than that of commercial product. It is suggested that captopril matrix tablets using PEO is a useful sustained release formulation.
흑삼에서 벤조피렌의 추출 조건 및 분석 방법에 관한 연구
조영호(Young Ho Cho),송규용(Kyu Yong Song),백명기(Myoung Ki Baek),이종화(Jong Wha Lee),이계원(Gye Won Lee) 대한약학회 2012 약학회지 Vol.56 No.3
To develop fundamental data of herbal materials with heat treatment, we studied analytical and extraction methods of benzopyrene in black ginseng and validated by HPLC analysis. Benzopyrene was successfully separated in mobile phase of acetonitrile:water (80 : 20) and detection of excitation 294 nm, emission 404 nm. The calibration curve of benzopyrene was linear over the concentration range of 1.17~37.50 ng/ml with correlation coefficient of above 0.999. The limit of detection (LOD) and quantitation (LOQ) of benzopyrene was 0.25 and 0.75 ng/ml, respectively. Hexane extraction method was used as a new extraction method for benzopyren and the efficient of extraction was over 95%. In conclusion, analytical method and extraction method were suitable for the determination of benzopyrene in the black ginseng and could be applied to fundamental study and guideline of herbal materials with heat treatment.
마이크로플루다이저를 이용한 아클라루비신 리포좀의 제조 및 평가
박목순(Mork Soon Park),박진규(Jin Kyu Park),이계원(Gye Won Lee),백명기(Myoung Ki Baek),지웅길(Ung Kil Lee) 대한약학회 1998 약학회지 Vol.42 No.3
In order to attain a sustained release at targeted organs in a prolonged time which can reduce the side effects and maximize the therapeutic effect, aclarubicin (ACL) was entrapped into liposomes of different lipid compositions using Microfluidizer, and dry liposomes were prepared by lyophilization. The dry aclarubicin-entrapped liposomes were evaluated in terms of mean particle size and size distribution, entrapment efficiency and in vitro drug release profile. The Entrapment efficiency of liposome, when the concentration of aclarubicin and lipid were 0.5 to 1.0mg/ml and 200mcmol/ml,respectively, was over 80% using Microfluidizer, in contrast to 70% of entrapment efficiency using hand-shaking method. Mean particle size and size distribution of aclarubicin-entrapped liposomes of various lipid compositions did not change considerably by the freeze drying. The range of particle size was between 80 and 200nm. Among aclarubicin-entrapped liposomes, ACL-liposome of PC/DPPC/CH0L/TA displayed the most significant sustained release. The addition of DPPC appeared to be favorable for the control of release. In general, aclarubicin entrapped in liposomes was less stable than free aclarubicin either in pH 7.4 phosphate buffer or in human plasma. Formulation I(t1/2, 20.3 hr) devoid of lipid additive was the most unstable in the phosphate-buffer solution while formulation II(t1/2, 40.7 hr) with cardiolipin was the most stable. Half lives of aclarubicin-entrapped liposomes in human plasma were 43.2, 50.7, 35.9 and 35.3 hr for formulation I. II, III and IV, respectively, in contrast to 57.8 hr for free aclarubicin.
조영호(Young Ho Cho),안계환(Ghe Whan Ahn),양승원(Seung Won Yang),조관현(Kwan Hyun Cho),김상원(Sang Won Kim),백명기(Ki Myoung Baek),이계원(Gye Won Lee) 한국생물공학회 2011 KSBB Journal Vol.26 No.6
Psolarea corylifolia extract that contains bakuchiol is known to have anti-microbial, anti-inflammatory and anti-scarring effects. In this study, a vesicles such as liposome, niosome, and transfersome were produced to encapsulate P. corylifolia extract and measured their stability and physiochemical property. The skin permeation and partitioning of P. corylifolia extract in the vesicles were elucidated in nude mouse skin by using Franz diffusion cells after topical application for 24 h. After storage at 25, 40, 70℃, and light, the stability of bakuchiol incorporated into the vesicles was maintained for 30 days. The optimal concentration of P. corylifolia extract entrapped into the vesicles was found to be 5~10%. From the physicochemical studies, after storage at 4, 25, and 40℃, the viscosity and particle size of the vesicles remained in 30~80 cP and the nanosize range for 6 months, respectively. From the permeation experiments, niosome showed a higher amount of bakuchiol permeated through the mouse skin compared to liposome and transfersome after 24 h. From these results, niosome and transfersome could be a good bioavailability enhancement system (BAES) for P. corylifolia extract to improve the skin permeation and stability.
케토프로펜을 함유하는 고형 지질 나노파티클의 제조 및 평가
백명기,이상영,지웅길 충남대학교 약학대학 의약품개발연구소 1996 藥學論文集 Vol.12 No.-
Solid lipid nanopaticles (SLN) have been developed as a new drug delivery system. Although many particulate drug carriers, such as microsphere, liposome, niosome, emulsion, etc have been introduced, they have some disadvantage: low efficiency of incorporation and stability, lack of reproducibility, and so on. Meanwhile, SLN as a new drug delivery system are known to entrap drugs with a high efficiency and a good reproducibility. Moreover, small size SLN can circulate in blood for a prolonged time. Although many preparation methods were introduced microfluidization method is recommended to be the most useful. This study was attempted to prepare and evaluate ketoprofen-incorporatd SLNs (keto-SLN), which were prepared by two methods, ultrasonication and microfluidization. Keto SLN was evaluated by measurement of particle size and zeta potential, efficacy of entrapment, sedimentation volume, in virto release pattern. The mean particle size was about 0.1 ㎛, and the size was dependent on the type and the amount of emulsifier. Zeta potential was negative. -9~-13㎷ and entrapment efficacy was very high and stability was good for at least 60 days in the respect of particle size and sedimentation volume ratio. Analgesic effect was also determined as well as pharmacokinetic parameters. The former was comparable to that of that of ketoprofen loaded suspension (keto-sus) and the latter revealed that consistent with the delayed release of keto-SLN T_max was longer than keto-sus. Therefore keto-SLN was favourable dosage forms in the field of drug delivery system such as anti-cancer. analgesics and anti-inflammatory agents.
케토프로펜을 함유하는 고형 지질 나노파티클의 제조 및 평가
지웅길,백명기,이상영 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.4
Solid lipid nanoparticles (SLN) have been developed as a new drug delivery system. Although many particulate drug carriers, such as microsphere, liposome, niosome, emulsion, etc. have been introduced, they have some disadvantage: low efficiency of incorporation and stability, lack of reproducibility, and so on. Meanwhile. SLN as a new drug delivery system is known to entrap drugs with a high efficiency and a good reproducibility. Moreover, small size SLN can circulate in blood for a prolonged time. Although many preparation methods were introduced, microfluidization method is recommended to be the most useful. This study was attempted to prepare and evaluate ketoprofen-incorporated SLNs (keto-SLN), which were prepared by two methods. ultrasonication and microfluidization. Keto-SLN was evaluated by measurement of particle size and zeta potential, efficacy of entrapment, sedimentation volume, in virto release pattern. The mean particle size was about 0.1 ㎛, and the size was dependent on the type and the amount of emulsifier. Zeta potential was negative. -9∼13mV and entrapment efficacy was very high and stability was good for at least 60 days in the respect of particle size and sedimentation volume ratio. Analgesic effect was also determined as well as pharmacokinetic parameters. The former was comparable to that of that of ketoprofen loaded suspension (keto-sus) and the latter revealed that consistent with the delayed release of keto-SLN. T_(max) was longer than keto-sus. Therefore, keto-SLN was favourable dosage forms in the field of drug delivery system such as anti-cancer, analgesics and anti-inflammatory agents.
폴리에틸렌옥시드를 이용한 캅토프릴 메트릭스 정제의 제조 및 약물동력학적 평가
지웅길,백명기,장혁 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.1
The captopril matrix tablets composed of polyethylene oxide(PEO) was prepared and administered to beagle dogs. Captopril matrix tablets were prepared using direct compressed method and wet granulation compressed method with various ratios of drug to PEO. The diffusion rate of captopril matrix tablets followed on the Higuchi's diffusion model. With increasing hardness of captopril matrix tablets, release rate was decreased. Each formulation was evaluated by the area under the curve (AUC) and time course of plasma captopril concentration after oral administration to beagle dogs. The AUC_(0-12) were 9.126 ㎍·h/㎖ and 6.417 ㎍·h/㎖ for the matrix tablets and conventional tablets, respectively. Therefore, the bioavailability of captopril matrix tablets was greater than that of commercial product. It is suggested that captopril matrix tablets using PEO is a useful sustained release formulation.