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냉온처치가 20대 만성요통환자의 고유수용성감각과 근활성도에 미치는 영향
우보영 ( Bo-young Woo ),김민지 ( Min-ji Kim ),김효정 ( Hyo-jeong Kim ),박진옥 ( Jin-ok Park ),박찬규 ( Chan-kyu Park ),이찬호 ( Chan-ho Lee ),정소희 ( So-hee Jeong ),황동우 ( Dong-woo Hwang ),손호희 ( Ho-hee Son ) 대한신경치료학회 2018 신경치료 Vol.22 No.2
Purpose The Purpose of this study was to investigate the effects of cold and hot intervention on proprioceptio and nmuscle activity in low back pain patients. Methods The intervention was applied to the lumbar joint for 15 minutes and repositioning test was inspected at 30° and 60° trunk flexion to measure the proprioception. In addition, muscle activity was measured at 30° with EMG. All measurements and tests were implemented before and after the intervention. Results The results showed that repositioning error was significant only in the 30° trunk flexion posture of the hot intervention group. In the case of muscle activity, the muscle activity increased in the hot intervention group and the muscle activity decreased in the cold intervention group. Conclusion In this study cold and hot intervention did not affect the proprioception. In the case of cold intervention, the muscle activity was decreased, but the joint may become stiff and there is a risk of injury. In the case of hot intervention, the muscle activity is increased. But according to the preceding articles, after the long-term hot intervention, the decrease in muscle activity can be predictable. This may be helpful in decreasing the muscle activity of back pain patients who have more muscle activity than normal people due to the presence of maladaptive muscleguarding to protect the spine.
대장균 리보스 결합단백질의 수송결함 돌연변이 rbsB(-14)AE의 분리 및 분석
이영희,박순희,김정호,박찬규,Lee, Young-Hee,Park, Soon-Hee,Kim, Jeong-Ho,Park, Chan-Kyu 생화학분자생물학회 1993 한국생화학회지 Vol.26 No.3
Signal sequence mutation of ribose-binding protein (RBP) in Escherichia coli, which has glutamic acid instead of alanine at the position of -14, was introduced by site-directed mutagenesis. This mutation named rbsB(-14)AE resulted in about 70% decrease of RBP export comparing with that of wild type. The export defect induced by rbsB(-14)AE was mitigated by the recombined intragenic suppressors such as rbsB27AG, rbsB27AT, and rbsB36 VE selected for rbsB103[rbsB(-17)LP]. The involvement of SecB, a molecular chaperone, was investigated in the suppression of rbsB(-14)AE mutation by these suppressors. Translocation efficiency was found to be increased by the presence of SecB for all suppressors as shown for rbsB103. 대장균의 리보스 결합단백질(ribose-binding protein, RBP)의 단백질 수송 신호배열에 자리특이적 돌연변이 유발법을 이용하여 -14 위치의 알라닌을 글루타민산으로 변화시키는 변이를 유발하였다. 이 신호배열 돌연변이, rbsB(-14)AE는 야생형과 비교하였을 때 RBP의 수송이 70% 이상 감소한 수송 결핍을 초래하였다. 리보스 결합단백질의 수송을 완전히 봉쇄하는 rbsB103 [rbsB(-17)LP] 신호배열 돌연변이에 대한 숙성체내 회복돌연변이들인 rbsB27AG, rbsB27AT, rbsB36VE(이등, 1991, 한국미생물학회지, 29(5), 270)와 rbsB(-14)AE의 유전자를 재조합하여 상호작용하는지를 관찰한 결과 각 숙성체내 회복돌연변이에 의해 RBP 수송이 증가하였다. Molecular chaperone인 SecB는 rbsB(-14)AE의 수송결핍을 회복시키는 이들 회복돌연변이의 수송회복도를 증가시켰다.